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Chemical‐Reductant‐Free Electrochemical Deuteration Reaction using Deuterium Oxide
Abstract
We report a method for the electrochemical deuteration of α,β‐unsaturated carbonyl compounds under catalyst‐ and external‐reductant‐free conditions, with deuteration rates as high as 99 % and yields up to 91 % in 2 h. The use of graphite felt for both the cathode and the anode was key to ensuring chemoselectivity and high deuterium incorporation under neutral conditions without the need for an external reductant. This method has a number of advantages over previously reported deuteration reactions that use stoichiometric metallic reductants. Mechanistic experiments showed that O 2 evolution at the anode not only eliminates the need for an external reductant but also regulates the pH of the reaction mixture, keeping it approximately neutral.
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Cited by
Electrochemical Late-Stage Functionalization
Wang, Y., Dana, S., Long, H., Xu, Y., Li, Y., Kaplaneris, N., & Ackermann, L. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00158 · Cited by 361
Electrochemical hydrogenation and oxidation of organic species involving water
Liu, C., Chen, F., Zhao, B.-H., Wu, Y., & Zhang, B. (2024) · Nature Reviews Chemistry · doi:10.1038/s41570-024-00589-z · Cited by 269
Direct electrochemical defluorinative carboxylation of α-CF 3 alkenes with carbon dioxide
Gao, X.-T., Zhang, Z., Wang, X., Tian, J.-S., Xie, S.-L., Zhou, F., & Zhou, J. (2020) · Chemical Science · doi:10.1039/d0sc04091f · Cited by 142
Metadata
- Authors
- Liu, X., Liu, R., Qiu, J., Cheng, X., & Li, G.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-06-04
- Volume
- 59
- Issue
- 33
- Pages
- 13962-13967
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3025939825
- Cited by
- 189
- References
- 0
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Chemical‐Reductant‐Free Electrochemical Deuteration Reaction using Deuterium Oxide. https://app.cochat.ai/papers/10.1002/anie.202005765
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- Liu, X., Liu, R., Qiu, J., Cheng, X., & Li, G. (2020). Chemical‐Reductant‐Free Electrochemical Deuteration Reaction using Deuterium Oxide. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202005765
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