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Cited by 152Osteoarthritis Treatment and MechanismsMusculoskeletal pain and rehabilitationSmoking Behavior and Cessation

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Does smoking protect against osteoarthritis?

Felson, David T., Anderson, Jennifer J., Naimark, Allan, Hannan, Marian T., Kannel, William B., Meenan, Robert F.·1989·Arthritis & Rheumatism
DOI 10.1002/anr.1780320209
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Abstract

While studying knee osteoarthritis (OA) in the first Health and Nutrition Examination Survey, we unexpectedly found a protective association between smoking and OA. After adjustment for age, sex, and weight, smokers had a significantly lower rate of OA than did nonsmokers, and heavier smokers were less likely to have the disease than were light smokers. To test this association in a separate study and see if it was due to confounding factors, we looked at the Framingham Osteoarthritis Study, a study of elderly members of the Framingham Heart Study cohort. We evaluated whether the presence of knee OA in 1983–1985 was related to smoking status at the first Framingham examination, 36 years earlier. Subjects who had been smokers at examination 1 had a lower rate of OA (190 of 679, 28%) than did nonsmokers (276 of 736, 37.5%). In an analysis adjusted for age, sex, and weight, heavy smokers had a modestly lower risk of developing knee OA than did nonsmokers (relative risk 0.81). Also, the adjusted risk of severe OA was less in heavy smokers than in nonsmokers (relative risk 0.73). The negative association with OA persisted when we examined the average cigarette consumption over the first 10 years of the Framingham study. Furthermore, after controlling for age, sex, weight, knee injury history, sports activity history, physical activity level, coffee and alcohol consumption, and weight change after examination 1, and after modeling weight and age in a nonlinear manner, smoking remained a significant protector against later knee OA. It appears that smoking or some unidentified factor correlated with smoking modestly protects against the development of knee OA.

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Crossref · 10.1002/anr.1780320209

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Research works printed but not linked: 6

  1. 1973, Plan and operation of Health and Nutrition Examination Survey
  2. Kellgren J, 1963, The epidemiology of chronic rheumatism, Atlas of Standard Radiographs
  3. Metropolitan Life Insurance Company, 1959, New weight standards for men and women, Stat Bull Metropol Life Insur Co, 40, 1
  4. Radin EL, 1976, Mechanical aspects of osteoarthritis, Bull Rheum Dis, 26, 862
  5. Lindsay R, 1981, The influence of cigarette smoking on bone mass and bone loss, Osteoporosis: Recent Advances in Pathogenesis and Treatment
  6. Rundgren A, 1986, The effect of tobacco smoking on the mineral content of the heel bone in 70, 75, and 79‐year‐old men and women, Osteoporosis

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Metadata

Authors
Felson, D. T., Anderson, J. J., Naimark, A., Hannan, M. T., Kannel, W. B., & Meenan, R. F.
Affiliations
Boston University (US)
Corresponding author
Felson, David T.
ORCID
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
1989-02
Volume
32
Issue
2
Pages
166-172
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/anr.1780320209
OpenAlex
W2062888212
Cited by
147
References
21
Citations by year
2026: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 8 · 2012: 2
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 6155 d)
Locations
  • Arthritis & Rheumatism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-20613)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords
smoking, knee osteoarthritis, osteoarthritis risk, protective effect of smoking, cigarette consumption, confounding factors, Health and Nutrition Examination Survey, physical activity, weight
MeSH terms
Adult, Age Factors, Aged, Body Weight, Female, Humans, Knee Joint, Male, Middle Aged, Osteoarthritis, Sex Factors, Smoking

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