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Dynamic swelling behavior of pH‐sensitive anionic hydrogels used for protein delivery
Abstract
There have been many attempts to use anionic hydrogels as oral protein delivery carriers because of their pH‐responsive swelling behavior. The dynamic swelling behavior of poly(methacrylic acid‐co‐methacryloxyethyl glucoside) and poly(methacrylic acid‐g‐ethylene glycol) hydrogels was investigated to determine the mechanism of water transport through these anionic hydrogels. The exponential relation Mt/M∞ = ktn (where Mt is the mass of water absorbed at time t and M∞ is the mass of water absorbed at equilibrium) was used to calculate the exponent (n) describing the Fickian or non‐Fickian behavior of swelling polymer networks. The mechanism of water transport through these gels was significantly affected by the pH of the swelling medium. The mechanism of water transport became more relaxation‐controlled in a swelling medium of pH 7.0, which was higher than p Ka of the gels. The experimental results of the time‐dependent swelling behaviors of the gels were analyzed with several mathematical models. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 1606–1613, 2003
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Cited by
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023
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Lin, C.-C., & Metters, A. T. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.004 · Cited by 1,768
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Ratner, B. D., & Bryant, S. J. (2004) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.6.040803.140027 · Cited by 1,507
Responsive polymers in controlled drug delivery
Bajpai, A. K., Shukla, S. K., Bhanu, S., & Kankane, S. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2008.07.005 · Cited by 1,391
Therapeutic applications of hydrogels in oral drug delivery
Sharpe, L. A., Daily, A. M., Horava, S. D., & Peppas, N. A. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.902047 · Cited by 354
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Metadata
- Authors
- Kim, B., La Flamme, K., & Peppas, N. A.
- Venue
- Journal of Applied Polymer Science
- Publisher
- Wiley
- Published
- 2003-05-23
- Volume
- 89
- Issue
- 6
- Pages
- 1606-1613
- ISSN
- 0021-8995 (ISSN-L)
- 1097-4628
- OpenAlex
- W2131024128
- Cited by
- 270
- References
- 0
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, B., La Flamme, K., & Peppas, N. A. (2003). Dynamic swelling behavior of pH‐sensitive anionic hydrogels used for protein delivery. Journal of Applied Polymer Science. https://doi.org/10.1002/app.12337
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