Thermo- and pH-responsive polymers in drug delivery☆

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works

Poly(N-isopropylacrylamide): experiment, theory and application

Schild, H. G. (1992) · Progress in Polymer Science · doi:10.1016/0079-6700(92)90023-r · Cited by 5,162 · see citing works

Cancer nanotechnology: opportunities and challenges

Ferrari, M. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1566 · Cited by 4,558 · see citing works

Untitled work

(1989) · PubMed · Cited by 3,343 · see citing works

The dawning era of polymer therapeutics

Duncan, R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1088 · Cited by 3,273 · see citing works

Polymer conjugates as anticancer nanomedicines

Duncan, R. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1958 · Cited by 1,956 · see citing works

Poly(ethylene oxide)poly(propylene oxide)poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling

Alexandridis, P., & Hatton, T. A. (1995) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/0927-7757(94)03028-x · Cited by 1,934 · see citing works

Stimuli responsive polymers for biomedical applications

Alarcón, C. D. L. H., Pennadam, S. S., & Alexander, C. (2005) · Chemical Society Reviews · doi:10.1039/b406727d · Cited by 1,692 · see citing works

Volume phase transition in a nonionic gel

Hirokawa, Y., & Tanaka, T. (1984) · The Journal of Chemical Physics · doi:10.1063/1.447548 · Cited by 1,608 · see citing works

Collapse of Gels and the Critical Endpoint

Tanaka, T. (1978) · Physical Review Letters · doi:10.1103/physrevlett.40.820 · Cited by 1,588 · see citing works

Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications

Esfand, R., & Tomalia, D. A. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)01757-3 · Cited by 1,562 · see citing works

A polymer gel with electrically driven motility

Osada, Y., Okuzaki, H., & Hori, H. (1992) · Nature · doi:10.1038/355242a0 · Cited by 1,307 · see citing works

Collapse of Gels in an Electric Field

Tanaka, T., Nishio, I., Sun, S.-T., et al. (1982) · Science · doi:10.1126/science.218.4571.467 · Cited by 1,296 · see citing works

Phase Transitions in Ionic Gels

Tanaka, T., Fillmore, D. J., Sun, S.-T., et al. (1980) · Physical Review Letters · doi:10.1103/physrevlett.45.1636 · Cited by 1,256 · see citing works

Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH

Chen, G., & Hoffman, A. S. (1995) · Nature · doi:10.1038/373049a0 · Cited by 1,221 · see citing works

Dendrimer biocompatibility and toxicity

Duncan, R., & Izzo, L. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.019 · Cited by 1,153 · see citing works

Phase transition of aqueous solutions of poly(N-isopropylacrylamide) and poly(N-isopropylmethacrylamide)

Fujishige, S., Kubota, K., & Ando, I. (1989) · The Journal of Physical Chemistry · doi:10.1021/j100345a085 · Cited by 1,143 · see citing works

Phase transition in polymer gels induced by visible light

Suzuki, A., & Tanaka, T. (1990) · Nature · doi:10.1038/346345a0 · Cited by 1,035 · see citing works

Dendrimers in gene delivery

Dufès, C., Uchegbu, I. F., & Schätzlein, A. G. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.09.017 · Cited by 984 · see citing works

Physical Chemistry of Biological Free Energy Transduction As Demonstrated by Elastic Protein-Based Polymers

Urry, D. W. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp972167t · Cited by 849 · see citing works

Comparison of the Coil-to-Globule and the Globule-to-Coil Transitions of a Single Poly(N-isopropylacrylamide) Homopolymer Chain in Water

Wang, X., Qiu, X., & Wu, C. (1998) · Macromolecules · doi:10.1021/ma971873p · Cited by 706 · see citing works

Acidic Extracellular pH Promotes Experimental Metastasis of Human Melanoma Cells in Athymic Nude Mice

Rofstad, E. K., Mathiesen, B. S., Kindem, K., & Galappathi, K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0983 · Cited by 668 · see citing works

Polymeric micelle for tumor pH and folate-mediated targeting

Lee, E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00239-6 · Cited by 620 · see citing works

Pulsatile drug release control using hydrogels

Kikuchi, A., & Okano, T. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00243-5 · Cited by 600 · see citing works

Physicochemical Principles of Pharmacy

Florence, A. J., & Attwood, D. (1981) · doi:10.1007/978-1-349-19480-3 · Cited by 589 · see citing works

Biodegradable block copolymers for delivery of proteins and water-insoluble drugs

Zentner, G. M., Rathi, R. C., Shih, C., McRea, J. C., Seo, M.-H., Oh, H., Rhee, B.-O., Mestecky, J. F., Moldoveanu, Z., Morgan, M. E., et al. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00276-0 · Cited by 587 · see citing works

Switching the Inside and the Outside of Aggregates of Water-Soluble Block Copolymers with Double Thermoresponsivity

Arotçaréna, M., Heise, B., Ishaya, S., & Laschewsky, A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja012167d · Cited by 557 · see citing works

Volume transition in a gel driven by hydrogen bonding

Ilmain, F., Tanaka, T., & Kokufuta, E. (1991) · Nature · doi:10.1038/349400a0 · Cited by 509 · see citing works

Semi‐Automated Synthesis and Screening of a Large Library of Degradable Cationic Polymers for Gene Delivery

Anderson, D. G., Lynn, D. M., & Langer, R. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200351244 · Cited by 508 · see citing works

A novel approach for preparation of pH-sensitive hydrogels for enteric drug delivery

Dong, L.-C., & Hoffman, A. S. (1991) · Journal of Controlled Release · doi:10.1016/0168-3659(91)90072-l · Cited by 449 · see citing works

Trimethylated chitosans as non-viral gene delivery vectors: Cytotoxicity and transfection efficiency

Kean, T. J., Roth, S., & Thanou, M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.01.001 · Cited by 391 · see citing works

Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability

Godbey, W. T., Wu, K. K., & Mikos, A. G. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00203-9 · Cited by 361 · see citing works

Thermosensitivity of Aqueous Solutions of Poly(N,N-diethylacrylamide)

Idziak, I., Avoce, D., Lessard, D. G., et al. (1999) · Macromolecules · doi:10.1021/ma981171f · Cited by 354 · see citing works

DNA condensation with polyamines

Gosule, L. C., & Schellman, J. A. (1978) · Journal of Molecular Biology · doi:10.1016/0022-2836(78)90366-2 · Cited by 344 · see citing works

DNA condensation with polyamines

Chattoraj, D. K., Gosule, L. C., & Schellman, J. A. (1978) · Journal of Molecular Biology · doi:10.1016/0022-2836(78)90367-4 · Cited by 329 · see citing works

Photoresponsive polymer–enzyme switches

Shimoboji, T., Larenas, E., Fowler, T., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262427799 · Cited by 322 · see citing works

Temperature-Responsive Interpenetrating Polymer Networks Constructed with Poly(acrylic acid) and Poly(N,N-dimethylacrylamide)

Aoki, T., Kawashima, M., Katono, H., Sanui, K., Ogata, N., Okano, T., & Sakurai, Y. (1994) · Macromolecules · doi:10.1021/ma00082a010 · Cited by 314 · see citing works

Regulation of Organelle Acidity

Grabe, M., & OSTER, G. F. (2001) · The Journal of General Physiology · doi:10.1085/jgp.117.4.329 · Cited by 306 · see citing works

Dynamic swelling behavior of pH‐sensitive anionic hydrogels used for protein delivery

Kim, B., Flamme, K. L., & Peppas, N. A. (2003) · Journal of Applied Polymer Science · doi:10.1002/app.12337 · Cited by 270 · see citing works

Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells

Watson, P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.05.003 · Cited by 265 · see citing works

Reentrant phase transition of N -isopropylacrylamide gels in mixed solvents

Amiya, T., Hirokawa, Y., Hirose, Y., et al. (1987) · The Journal of Chemical Physics · doi:10.1063/1.452740 · Cited by 263 · see citing works

A polymer library approach to suicide gene therapy for cancer

Anderson, D. G., Peng, W., Akinc, A., Hossain, N., Kohn, A., Padera, R. F., Langer, R., & Sawicki, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407218101 · Cited by 258 · see citing works

Size-dependent control of the binding of biotinylated proteins to streptavidin using a polymer shield

Ding, Z., Fong, R. B., Long, C. J., et al. (2001) · Nature · doi:10.1038/35075028 · Cited by 245 · see citing works

Overcoming the Nuclear Barrier: Cell Cycle Independent Nonviral Gene Transfer with Linear Polyethylenimine or Electroporation

Brunner, S., Fuertbauer, E., Sauer, T., Kursa, M., & Wagner, E. (2002) · Molecular Therapy · doi:10.1006/mthe.2001.0509 · Cited by 244 · see citing works

Evaluation of an elastin-like polypeptide–doxorubicin conjugate for cancer therapy

Dreher, M. R. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00216-5 · Cited by 241 · see citing works

Coil-globule transition of poly(N-isopropylacrylamide): a study of surfactant effects by light scattering

Meewes, M., Rička, J., Silva, M. D., Nyffenegger, R. M., & Binkert, T. (1991) · Macromolecules · doi:10.1021/ma00021a014 · Cited by 235 · see citing works

Shape Transition of Magnetic Field Sensitive Polymer Gels

Szabó, D., Szeghy, G., & Zrı́nyi, M. (1998) · Macromolecules · doi:10.1021/ma980284w · Cited by 224 · see citing works

Light-Scattering Study of Coil-to-Globule Transition of a Poly( N -isopropylacrylamide) Chain in Deuterated Water

Wang, X., & Wu, C. (1999) · Macromolecules · doi:10.1021/ma9902450 · Cited by 223 · see citing works

Thermoresponsive Surface-Grafted Poly(N−isopropylacrylamide) Copolymers: Effect of Phase Transitions on Protein and Bacterial Attachment

Cunliffe, D. A., Alarcón, C. D. L. H., Peters, V., et al. (2003) · Langmuir · doi:10.1021/la026358l · Cited by 221 · see citing works

Sustained delivery of plasmid DNA from polymeric scaffolds for tissue engineering☆

Storrie, H., & Mooney, D. J. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.004 · Cited by 211 · see citing works

Thermo-Responsive PNiPAAm-g-PEG Films for Controlled Cell Detachment

Schmaljohann, D., Oswald, J., Jørgensen, B., et al. (2003) · Biomacromolecules · doi:10.1021/bm034160p · Cited by 205 · see citing works

Macromolecule hydration and the effect of solutes on the cloud point of aqueous solutions of polyvinyl methyl ether: A possible model for protein denaturation and temperature control in homeothermic animals

Horne, R. A., Almeida, J., Day, A. F., et al. (1971) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(71)90187-1 · Cited by 185 · see citing works

Control of Flow Direction in Microfluidic Devices with Polyelectrolyte Multilayers

Barker, S. L. R., Ross, D., Tarlov, M. J., et al. (2000) · Analytical Chemistry · doi:10.1021/ac0008690 · Cited by 185 · see citing works

Structural optimization of a “smart” doxorubicin–polypeptide conjugate for thermally targeted delivery to solid tumors

Furgeson, D. Y., Dreher, M. R., & Chilkoti, A. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.10.006 · Cited by 176 · see citing works

A Family of Hierarchically Self‐Assembling Linear‐Dendritic Hybrid Polymers for Highly Efficient Targeted Gene Delivery

Wood, K. C., Little, S. R., Langer, R., & Hammond, P. T. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200502152 · Cited by 168 · see citing works

Cross-link Density Dependence of Spatial Inhomogeneities and Dynamic Fluctuations of Poly(N-isopropylacrylamide) Gels

Shibayama, M., Norisuye, T., & Nomura, S. (1996) · Macromolecules · doi:10.1021/ma9609994 · Cited by 160 · see citing works

pH-Wert des Milieus chronischer Wunden

Dissemond, J., Witthoff, M., Brauns, T., Haberer, D., & Goos, M. (2003) · Der Hautarzt · doi:10.1007/s00105-003-0554-x · Cited by 142 · see citing works

Stimuli-responsive poly(N-isopropylacrylamide). Photo- and chemical-induced phase transitions

Irie, M. (2005) · Springer eBooks · doi:10.1007/bfb0021128 · Cited by 138 · see citing works

Temperature and pH-sensitive Polymers for Human Calcitonin Delivery

Serres, A., Baudyš, M., & Kim, S. W. (1996) · Pharmaceutical Research · doi:10.1023/a:1016026711364 · Cited by 130 · see citing works

Microcalorimetric Study of Thermal Cooperative Transitions in Poly(N-vinylcaprolactam) Hydrogels

Mikheeva, L. M., Grinberg, N. V., Mashkevich, A. Y., et al. (1997) · Macromolecules · doi:10.1021/ma9615112 · Cited by 130 · see citing works

Conformational Changes of Poly(vinylcaprolactam) Macromolecules and Their Complexes with Ionic Surfactants in Aqueous Solution

Makhaeva, E. E., Tenhu, H. J., & Khokhlov, A. R. (1998) · Macromolecules · doi:10.1021/ma980158s · Cited by 124 · see citing works

Hydrophobic weak polyelectrolyte gels: Studies of swelling equilibria and kinetics

Siegel, R. A. (1993) · Advances in polymer science · doi:10.1007/3-540-56791-7_6 · Cited by 122 · see citing works

Polyhistidine–PEG:DNA nanocomposites for gene delivery

Putnam, D. A., Zelikin, A. N., Izumrudov, V. A., & Langer, R. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00341-7 · Cited by 121 · see citing works

Poly(Amidoamine)s as Potential Nonviral Vectors: Ability to Form Interpolyelectrolyte Complexes and to Mediate Transfection in Vitro

Richardson, S. C. W., Pattrick, N. G., Man, Y. K. S., Ferruti, P., & Duncan, R. (2001) · Biomacromolecules · doi:10.1021/bm010079f · Cited by 121 · see citing works

Preparation of Shell Cross‐Linked Micelles by Polyelectrolyte Complexation

Weaver, J. V. M., Tang, Y., Liu, S., et al. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200352428 · Cited by 121 · see citing works

Polymeric Drugs and Drug Delivery Systems

(2000) · CRC Press eBooks · doi:10.1201/9781420010251 · Cited by 113 · see citing works

Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques

van de Weert, M., Hof, R. V., van der Weerd, J., Heeren, R. M. A., Posthuma, G., Hennink, W. E., & Crommelin, D. J. A. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00227-3 · Cited by 112 · see citing works

pH/temperature-sensitive polymers for macromolecular drug loading and release

Yong-Hee, K., Bae, Y. H., & Kim, S. W. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90161-9 · Cited by 111 · see citing works

Amphoteric Linear Poly(amido-amine)s as Endosomolytic Polymers: Correlation between Physicochemical and Biological Properties

Ferruti, P., Manzoni, S., Richardson, S. C. W., Duncan, R., Pattrick, N. G., Mendichi, R., & Casolaro, M. (2000) · Macromolecules · doi:10.1021/ma000378h · Cited by 111 · see citing works

Phase Transitions in Swollen Networks. 3. Swelling Behavior of Radiation Cross-Linked Poly(vinyl methyl ether) in Water

Moerkerke, R., Meeussen, F., Koningsveld, R., et al. (1998) · Macromolecules · doi:10.1021/ma971512+ · Cited by 109 · see citing works

Influence of Poly(ethylene oxide) Grafts on Kinetics of LCST Behavior in Aqueous Poly(N-vinylcaprolactam) Solutions and Networks Studied by Modulated Temperature DSC

Durme, K. V., Verbrugghe, S., Prez, F. D., et al. (2004) · Macromolecules · doi:10.1021/ma035319t · Cited by 102 · see citing works

Interaction of Hydrophobically‐Modified Poly‐N‐isopropylacrylamides with Model Membranes—or Playing a Molecular Accordion

Ringsdorf, H., Venzmer, J., & Winnik, F. M. (1991) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199103151 · Cited by 101 · see citing works

Polymeric Drug Delivery Systems

(2005) · CRC Press eBooks · doi:10.1201/9780849348129 · Cited by 98 · see citing works

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

Ogata, N., Kim, S. W., Feijén, J., & Okano, T. (1996) · Springer eBooks · doi:10.1007/978-4-431-65883-2 · Cited by 97 · see citing works

A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides

Hussain, M., Shchepinov, M. S., Sohail, M. F., Benter, I. F., Hollins, A. J., Southern, E. M., & Akhtar, S. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.06.009 · Cited by 91 · see citing works

Synthetic polymers as drugs and therapeutics

Twaites, B. R., Alarcón, C. D. L. H., & Alexander, C. (2004) · Journal of Materials Chemistry · doi:10.1039/b410799n · Cited by 86 · see citing works

pH-Sensitive Polymers for Drug Delivery

(2005) · CRC Press eBooks · doi:10.1201/9780849348129-6 · Cited by 86 · see citing works

Evaluation of pH-dependent membrane-disruptive properties of poly(acrylic acid) derived polymers

Kusonwiriyawong, C., van de Wetering, P., Hubbell, J. A., et al. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00093-6 · Cited by 82 · see citing works

Immobilization of Cell-Adhesive Peptides to Temperature-Responsive Surfaces Facilitates Both Serum-Free Cell Adhesion and Noninvasive Cell Harvest

Ebara, M., Yamato, M., Aoyagi, T., et al. (2004) · Tissue Engineering · doi:10.1089/ten.2004.10.1125 · Cited by 81 · see citing works

Swelling Behavior of γ-Irradiation Cross-Linked Elastomeric Polypentapeptide-Based Hydrogels

Lee, J., Macosko, C. W., & Urry, D. W. (2001) · Macromolecules · doi:10.1021/ma0015673 · Cited by 73 · see citing works

In vitro and in vivo gene transfer with poly(amino acid) vesicles

Brown, M. D. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.08.022 · Cited by 65 · see citing works

Solution Properties of Hydrophobically Modified Copolymers of N-Isopropylacrylamide and N-Glycine Acrylamide: A Study by Microcalorimetry and Fluorescence Spectroscopy

Principi, T., Goh, C., Liu, R. C. W., et al. (2000) · Macromolecules · doi:10.1021/ma9919054 · Cited by 64 · see citing works

Stimuli‐sensitivities of hydrogels containing phosphate groups

Miyata, T., Nakamae, K., Hoffman, A. S., & Kanzaki, Y. (1994) · Macromolecular Chemistry and Physics · doi:10.1002/macp.1994.021950401 · Cited by 62 · see citing works

Synthesis and Characterization of Thermoresponsive Graft Copolymers of NIPAAm and 2-Alkyl-2-oxazolines by the “Grafting from” Method

Rueda, J. C., Zschoche, S., Komber, H., et al. (2005) · Macromolecules · doi:10.1021/ma050570p · Cited by 60 · see citing works

Packaging of DNA by shell crosslinked nanoparticles

Thurmond, K. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.14.2966 · Cited by 58 · see citing works

Genetic Engineering of Protein-Based Polymers: The Example of Elastinlike Polymers

Rodríguez‐Cabello, J. C., Reguera, J., Girotti, A., et al. (2005) · Advances in polymer science · doi:10.1007/12_047 · Cited by 56 · see citing works

Intravenous fate of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes

Verbaan, F. J., van Dam, I., Takakura, Y., Hashida, M., Hennink, W. E., Storm, G., & Oussoren, C. (2003) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2003.09.005 · Cited by 54 · see citing works

Swelling behavior of semi‐interpenetrating polymer network hydrogels composed of poly(vinyl alcohol) and poly(acrylamide‐co‐sodium methacrylate)

Mohan, Y. M., Murthy, P. S., Sreeramulu, J., & Raju, K. M. (2005) · Journal of Applied Polymer Science · doi:10.1002/app.21849 · Cited by 54 · see citing works

Synthesis and preliminary evaluation of poly(amidoamine)–melittin conjugates as endosomolytic polymers and/or potential anticancer therapeutics

Lavignac, N., Lazenby, M., Franchini, J., Ferruti, P., & Duncan, R. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.06.001 · Cited by 50 · see citing works

Influence of insulin immobilization to thermoresponsive culture surfaces on cell proliferation and thermally induced cell detachment

Hatakeyama, H., Kikuchi, A., Yamato, M., et al. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.061 · Cited by 50 · see citing works

Membrane‐Mimetic Nanocarriers Formed by a Dipalmitoylated Cell‐Penetrating Peptide

Keller, S., Sauer, I., Strauss, H. M., Gast, K., Dathe, M., & Bienert, M. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200500519 · Cited by 47 · see citing works

Transplantable retinal pigment epithelial cell sheets for tissue engineering

Kubota, A., Nishida, K., Yamato, M., Yang, J., Kikuchi, A., Okano, T., & Tano, Y. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.018 · Cited by 44 · see citing works

Lipase-catalyzed ring-opening polymerization and copolymerization of cyclic dicarbonates

Namekawa, S., Uyama, H., Kobayashi, S., & Kricheldorf, H. R. (2000) · Macromolecular Chemistry and Physics · doi:10.1002/(sici)1521-3935(20000201)201:2 · Cited by 41 · see citing works

Swelling behavior of hydrogels containing phosphate groups

Nakamae, K., Miyata, T., & Hoffman, A. S. (1992) · Die Makromolekulare Chemie · doi:10.1002/macp.1992.021930414 · Cited by 37 · see citing works

Synthesis and Endosomolytic Properties of Poly(amidoamine) Block Copolymers

Lavignac, N., Lazenby, M., Foka, P., Malgesini, B., Verpilio, I., Ferruti, P., & Duncan, R. (2004) · Macromolecular Bioscience · doi:10.1002/mabi.200400093 · Cited by 37 · see citing works

Perspectives on Polymeric Gene Delivery

Gebhart, C., & Kabanov, A. V. (2003) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911503018002005 · Cited by 32 · see citing works

Effect of molecular weight and polydispersity on kinetics of dissolution and release from pH/temperature-sensitive polymers

Ramkissoon-Ganorkar, C., Liu, F., Baudyš, M., & Kim, S. W. (1999) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856299x00739 · Cited by 31 · see citing works

Thermo-responsive polymers and hydrogels in tissue engineering

Schmaljohann, D. (2005) · e-Polymers · doi:10.1515/epoly.2005.5.1.221 · Cited by 30 · see citing works

The role of proteins in the nucleation and formation of calcium-containing deposits on biomaterial surfaces

Vasin, S. L., Rosanova, I. B., & Sevastianov, V. I. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19980305)39:3 · Cited by 26 · see citing works

Characterising the size and shape of polyamidoamines in solution as a function of pH using neutron scattering and pulsed-gradient spin-echo NMR.

Khayat, Z., Griffiths, P., Grillo, I., Heenan, R., King, S., & Duncan, R. (2006) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2006.03.003 · Cited by 26 · see citing works

Synthesis and biological evaluation of immunoconjugates of adriamycin and a human IgM linked by poly[N5-2-hydroxyethyl)-l-glutamine]

Hoes, C. J. T., Ankoné, M. J. K., Grootoonk, J., et al. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00126-3 · Cited by 13 · see citing works

Thermosensitive Biodegradable Hydrogels for the Delivery of Therapeutic Agents

Kwon, Y. M., & Kim, S. W. (2005) · Drugs and the pharmaceutical sciences · doi:10.1201/9780849348129.ch6 · Cited by 8 · see citing works

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

Knop, K., Hoogenboom, R., Fischer, D., & Schubert, U. S. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200902672 · Cited by 3,533 · see citing works

Engineered Nanoparticles for Drug Delivery in Cancer Therapy

Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164 · see citing works

Polymers for Drug Delivery Systems

Liechty, W. B., Kryscio, D. R., Slaughter, B. V., & Peppas, N. A. (2010) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-073009-100847 · Cited by 1,608 · see citing works

New directions in thermoresponsive polymers

Roy, D., Brooks, W. L. A., & Sumerlin, B. S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35499g · Cited by 1,311 · see citing works

Stimulus-responsive hydrogels: theory, modern advances, and applications

Koetting, M. C., Peters, J. T., Steichen, S. D., & Peppas, N. A. (2015) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2015.04.001 · Cited by 1,191 · see citing works

A review of stimuli-responsive shape memory polymer composites

Meng, H., & Li, G. (2013) · Polymer · doi:10.1016/j.polymer.2013.02.023 · Cited by 1,190 · see citing works

Stimulus-responsive shape memory materials: a review

Sun, L., Huang, W. M., Ding, Z., Zhao, Y., Wang, C. C., Purnawali, H., & Tang, C. (2012) · Materials & Design · doi:10.1016/j.matdes.2011.04.065 · Cited by 1,105 · see citing works

The Smart Drug Delivery System and Its Clinical Potential

Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066 · see citing works

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.061 · Cited by 1,004 · see citing works

Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review

Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998 · see citing works

Ph sensitive hydrogels in drug delivery: brief history, properties, swelling, and release mechanism, material selection and applications

Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844 · see citing works

Thermo-sensitive polymeric micelles based on poly (N-isopropylacrylamide) as drug carriers

Wei, H., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.05.002 · Cited by 718 · see citing works

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works

Thermo-responsive polymers and their application as smart biomaterials

Kim, Y.-J., & Matsunaga, Y. T. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00157f · Cited by 568 · see citing works

Temperature-responsive smart nanocarriers for delivery of therapeutic agents: applications and recent advances

Karimi, M., Sahandi Zangabad, P., Ghasemi, A., Amiri, M., Bahrami, M., Malekzad, H., Ghahramanzadeh Asl, H., Mahdieh, Z., Bozorgomid, M., Ghasemi, A., et al. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00371 · Cited by 500 · see citing works

Stimuli-responsive nanomaterials for therapeutic protein delivery

Lu, Y., Sun, W., & Gu, Z. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.015 · Cited by 415 · see citing works

Stimulus responsive nanogels for drug delivery

Zha, L., Banik, B., & Alexis, F. (2011) · Soft Matter · doi:10.1039/c0sm01307b · Cited by 391 · see citing works

<scp>pH</scp> ‐sensitive polymers: Classification and some fine potential applications

Ofridam, F., Tarhini, M., Lebaz, N., Gagnière, É., Mangin, D., & Elaissari, A. (2021) · Polymers for Advanced Technologies · doi:10.1002/pat.5230 · Cited by 286 · see citing works

Polymeric micelles: authoritative aspects for drug delivery

Kulthe, S. S., Choudhari, Y. M., Inamdar, N. N., & Mourya, V. (2012) · Designed Monomers and Polymers · doi:10.1080/1385772x.2012.688328 · Cited by 235 · see citing works

Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy

Wang, J., Li, S., Han, Y., Guan, J., Chung, S., Wang, C., & Li, D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00202 · Cited by 155 · see citing works

Surface functionalization of biomaterials by radical polymerization

Zhou, T., Zhu, Y., Li, X., Liu, X., Yeung, K. W. K., Wu, S., Wang, X., Cui, Z., Yang, X., & Chu, P. K. (2016) · Progress in Materials Science · doi:10.1016/j.pmatsci.2016.04.005 · Cited by 145 · see citing works

Polylactide-<i>graft</i>-doxorubicin Nanoparticles with Precisely Controlled Drug Loading for pH-Triggered Drug Delivery

Yu, Y., Chen, C.-K., Law, W.-C., Weinheimer, E., Sengupta, S., Prasad, P. N., & Cheng, C. (2014) · Biomacromolecules · doi:10.1021/bm401471p · Cited by 134 · see citing works

Mechanoresponsive materials for drug delivery: Harnessing forces for controlled release

Wang, J., Kaplan, J. A., Colson, Y. L., & Grinstaff, M. W. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.11.001 · Cited by 126 · see citing works

Stability of responsive polymer–protein bioconjugates

Shakya, A. K., Sami, H., Srivastava, A., & Kumar, A. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.01.003 · Cited by 110 · see citing works

Multifunctional and Stimuli‐Responsive Magnetic Nanoparticle‐Based Delivery Systems for Biomedical Applications

Yang, H. Y., Li, Y., & Lee, D. S. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800011 · Cited by 107 · see citing works

Ph-responsive drug delivery systems as intelligent carriers for targeted drug therapy: brief history, properties, synthesis, mechanism and application

Bami, M. S., Raeisi Estabragh, M. A., Khazaeli, P., Ohadi, M., & Dehghannoudeh, G. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102987 · Cited by 101 · see citing works

Galactose Targeted pH-Responsive Copolymer Conjugated with Near Infrared Fluorescence Probe for Imaging of Intelligent Drug Delivery

Fu, L., Sun, C., & Yan, L. (2015) · ACS Applied Materials &amp; Interfaces · doi:10.1021/am508291k · Cited by 78 · see citing works

Functional biomimetic nanoparticles for drug delivery and theranostic applications in cancer treatment

Li, L., Wang, J., Kong, H., Zeng, Y., & Liu, G. (2018) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2018.1528850 · Cited by 71 · see citing works

Enzyme-responsive protein/polysaccharide supramolecular nanoparticles

Hou, X.-F., Chen, Y., & Liu, Y. (2015) · Soft Matter · doi:10.1039/c4sm02896a · Cited by 65 · see citing works

Preparation and characterization of pH sensitive crosslinked Linseed polysaccharides-co-acrylic acid/methacrylic acid hydrogels for controlled delivery of ketoprofen

Shabir, F., Erum, A., Tulain, U. R., Hussain, M. A., Ahmad, M., & Akhter, F. (2017) · Designed Monomers and Polymers · doi:10.1080/15685551.2017.1368116 · Cited by 62 · see citing works

Bio‐based hyperbranched polyurethane/Fe₃O₄ nanocomposites as shape memory materials

Kalita, H., & Karak, N. (2013) · Polymers for Advanced Technologies · doi:10.1002/pat.3149 · Cited by 30 · see citing works

Development and characterization of skin permeation retardants and enhancers: a comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles

Azarbayjani, A. F., Khu, J. V., Chan, Y. W., & Chan, S. Y. (2011) · Biopharmaceutics &amp; Drug Disposition · doi:10.1002/bdd.766 · Cited by 24 · see citing works

Conjugates of stimuli‐responsive polymers and biomolecules: Random and site‐specific conjugates of temperature‐sensitive polymers and proteins

Hoffman, A. S., Stayton, P. S., Shimoboji, T., et al. (1997) · Macromolecular Symposia · doi:10.1002/masy.19971180173 · Cited by 17 · see citing works

Stimuli‐Responsive and ‘Active’ Polymers in Drug Delivery

Saeed, A. O., Magnusson, J. P., Twaites, B. R., et al. (2009) · doi:10.1002/9780470744697.ch3 · Cited by 1 · see citing works

Architecture and composition influence on the properties of some smart polymeric materials designed as matrices in drug delivery systems. A comparative study

Vasile, C., Dumitriu, R. P., Cheaburu-Yılmaz, C. N., et al. (2009) · Applied Surface Science · doi:10.1016/j.apsusc.2009.04.120 · Cited by 25 · see citing works

PNIPAM Poly (N-isopropylacrylamide): A Thermoresponsive “Smart” Polymer in Novel Drug Delivery Systems

Kokardekar, R. R., Shah, V. K., & Mody, H. R. (2012) · Internet Journal of Medical Update - EJOURNAL · Cited by 23 · see citing works

Switching between Polymer Architectures with Distinct Thermoresponses

Sun, W., An, Z., & Wu, P. (2017) · Macromolecular Rapid Communications · doi:10.1002/marc.201600808 · Cited by 6 · see citing works