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The effect of different sterilization procedures on chitosan dried powder
Abstract
The aim of this study was to investigate the effects induced by three different sterilization methods [steam, γ‐radiation, and ethylene oxide (EO)] with different dose or time period of sterilization by means of Fourier transform infrared spectroscopy, X‐ray diffraction, and assessments of molecular weight and degree of deacetylation. The experiment results clearly showed that the steam sterilization greatly darkened the color of chitosan powder; γ‐irradiation strongly depolymerized the chitosan especially at irradiation dose above 10 kGy; and exposure to EO led to minor change in crystallinity and network structure of chitosan powder. Therefore, these three methods have their respective advantages and disadvantages, suggesting that the selection of the sterilization method of chitosan should depend upon the specific requirement of the final application. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 1968–1972, 2007
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“Yang et al. [20] demonstrated that steam sterilization significantly darkens CS powder, gamma irradiation causes strong depolymerization above 10 kGy, and ethylene oxide induces only minor changes in crystallinity and structure.”
From Chitosan-Based Drug Delivery Systems for Targeted Chemotherapy in Colorectal Cancer: A Scoping Review (2025) · cites this paper as [20]
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Piotrowska, U., Szatko, J., Nowakowska, A., Klimaszewska, E., Ogorzałek, M., & Sobczak, M. (2025) · Marine Drugs · doi:10.3390/md23120467 · Cited by 14
Metadata
- Authors
- Yang, Y., Zhao, Y., Liu, X., Ding, F., & Gu, X.
- Venue
- Journal of Applied Polymer Science
- Publisher
- Wiley
- Published
- 2007-02-26
- Volume
- 104
- Issue
- 3
- Pages
- 1968-1972
- ISSN
- 0021-8995
- 1097-4628
- Cited by
- 52
- References
- 0
- Language
- en
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