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Cited by 74Wound Healing and TreatmentsElectrospun Nanofibers in Biomedical ApplicationsSurgical Sutures and Adhesives

Natural polymers in wound healing: From academic studies to commercial products

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Tavakoli, Mohamadreza, Labbaf, Sheyda, Mirhaj, Marjan, Salehi, Saeideh, Seifalian, Alexander Marcus, Firuzeh, Mahboubeh·2023·Journal of Applied Polymer Science
DOI 10.1002/app.53910
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Abstract

Natural biopolymers (carbohydrates and proteins) are the family of natural polymers that are widely used in wound healing. This is due to their biocompatibility and their chemical structural similarity to the extracellular matrix (ECM). Wound healing is a complex process and requires a multidisciplinary approach and appropriate treatment product to enable a full recovery. Chronic nonhealing wounds significantly caused the reduction. Currently, diabetic and nonhealing wounds are considered the unmet clinical need and a new effective treatment will benefit patients and the economy. This research was aimed to critically review both literature as well as industrial products that used carbohydrates and proteins in wound dressing for the treatment of the wound. The outcome was chitosan (CS), as a carbohydrate, has the most clinical application as it is readily available and affordable, and has shown excellent antibacterial activity. Among proteins, keratin (Kr) can be an option with similar characteristics, however, Kr has not yet found clinical use when compared with CS.

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  • Natural polymers often exhibit weaker mechanical properties, batch-to-batch variability, and scalability challenges.

    “However, they often exhibit weaker mechanical properties, batch-to-batch variability, and scalability challenges [17,18].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [18]

    The Introduction says natural polymers can vary from batch to batch and that environmentally dependent production may be slow, supporting the variability and production-challenge parts of the claim. Section 4.1.4 identifies poor mechanical properties in sericin specifically; it does not establish that natural polymers generally have weaker mechanical properties. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Tavakoli, M., Labbaf, S., Mirhaj, M., Salehi, S., Seifalian, A. M., & Firuzeh, M.
Affiliations
  • Isfahan University of Technology (IR)
  • Islamic Azad University of Najafabad (IR)
  • Nanotechnology & Regenerative Medicine Commercialization Centre (NanoRegMed Ltd., Nanoloom Ltd., Liberum Health Ltd.) London BioScience Innovation Centre London UK
Corresponding author
Labbaf, Sheyda
ORCID
Venue
Journal of Applied Polymer Science
Publisher
Wiley
Published
2023-04-12
Volume
140
Issue
22
ISSN
  • 0021-8995 (ISSN-L)
  • 1097-4628
DOI
10.1002/app.53910
OpenAlex
W4365149710
Cited by
74
References
2
Citations by year
2026: 13 · 2025: 20 · 2024: 31 · 2023: 10
FWCI
7.72
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
Journal of Applied Polymer Science (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
natural polymers, wound healing, wound dressings, chitosan, keratin, carbohydrates, proteins, extracellular matrix, chronic wounds, diabetic wounds, antibacterial activity, biocompatibility

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