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Sympathetic innervation of murine thymus and spleen: A comparative histofluorescence study
Abstract
Fluorescence microscopy of thymus and spleen from four strains of mice (C 3 H and ICR controls, AKR spontaneously leukemic and NZB autoimmune) revealed varicose noradrenergic (NE) fibers in perivascular and parenchymal regions of both organs. Thymic innervation was largely perivascular, but isolated islands and strings of free NE fibers were noted among thymic parenchymal cells. A morphological proximity between NE fibers in the thymus and mast cells was noted in all strains studied, but was exceptionally prominent in the NZB thymus. Perivascular plexuses within the splenic white pulp sent single NE fibers between the surrounding lymphocytes. Catecholamines and histamine have been shown to modulate lymphocyte development and activity in vitro. The present study provides morphological evidence that both NE and histamine are available to lymphocytes in thymus and spleen, and thus provides morphological evidence for neurla modulation of immune activity in vivo.
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Cited by
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252
Noradrenergic Sympathetic Neural Interactions with the Immune System: Structure and Function
Felten, D. L., Felten, S. Y., Bellinger, D. L., Carlson, S. L., Ackerman, K. D., Madden, K. S., Olschowki, J. A., & Livnat, S. (1987) · Immunological Reviews · doi:10.1111/j.1600-065x.1987.tb00534.x · Cited by 746
Self-citationAutonomic Nervous System and Immune System Interactions
Kenney, M. J., & Ganta, C. K. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130051 · Cited by 381
Felten, S. Y., & Olschowka, J. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180108 · Cited by 332
Cano, G., Sved, A. F., Rinaman, L., Rabin, B. S., & Card, J. P. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1331 · Cited by 237
Metadata
- Authors
- Williams, J. M., & Felten, D. L.
- Venue
- The Anatomical Record
- Publisher
- Wiley
- Published
- 1981-04
- Volume
- 199
- Issue
- 4
- Pages
- 531-542
- ISSN
- 0003-276X (ISSN-L)
- 1097-0185
- OpenAlex
- W2137716523
- Cited by
- 204
- References
- 0
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Williams, J. M., & Felten, D. L. (1981). Sympathetic innervation of murine thymus and spleen: A comparative histofluorescence study. The Anatomical Record. https://doi.org/10.1002/ar.1091990409
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