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Cited by 470

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis

Cambridge, Geraldine, Leandro, Maria J., Edwards, Jonathan C. W., Ehrenstein, Michael R., Salden, Martin, Bodman‐Smith, Mark, Webster, Anthony D. B.·2003·Arthritis & Rheumatism
DOI 10.1002/art.11181
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Abstract

Objective: To explore the changes in serologic variables and clinical disease activity following B lymphocyte depletion in 22 patients with rheumatoid arthritis (RA). Methods: B lymphocyte depletion was attained using combination therapy based on the monoclonal anti‐CD20 antibody rituximab. Levels of a serologic indicator of inflammation, C‐reactive protein (CRP), of antimicrobial antibodies, of autoantibodies including IgA‐, IgM‐, and IgG‐class rheumatoid factors (RF), and of antibodies to cyclic citrullinated peptide (anti‐CCP) were assayed. Results: The majority of patients showed a marked clinical improvement after treatment with rituximab, with benefit lasting up to 33 months. Levels of total serum immunoglobulins fell, although the mean values each remained within the normal range. Whereas the IgM‐RF response paralleled the changes in total serum IgM levels, the levels of IgA‐RF, IgG‐RF, and IgG and anti‐CCP antibodies decreased significantly more than did those of their corresponding total serum immunoglobulin classes. The kinetics for the reduction in CRP levels also paralleled the decreases in autoantibody levels. In contrast, levels of antimicrobial antibodies did not change significantly. B lymphocyte return occurred up to 21 months posttreatment. The time to relapse after B lymphocyte return was often long and unpredictable (range 0–17 months). Relapse was, however, closely correlated with rises in the level of at least one autoantibody. Increased autoantibody levels were rarely observed in the absence of clinical change. Conclusion: Following B lymphocyte depletion in patients with RA, a positive clinical response occurred in correlation with a significant drop in the levels of CRP and autoantibodies. Antibacterial antibody levels were relatively well maintained. B lymphocyte return preceded relapse in all patients. There was also a temporal relationship between clinical relapse and rises in autoantibody levels. Although these observations are consistent with a role for B lymphocytes in the pathogenesis of RA, the precise mechanisms involved remain unclear.

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Metadata

Authors
Cambridge, G., Leandro, M. J., Edwards, J. C. W., Ehrenstein, M. R., Salden, M., Bodman‐Smith, M., & Webster, A. D. B.
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
2003-08
Volume
48
Issue
8
Pages
2146-2154
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/art.11181
OpenAlex
W2122507029
Cited by
470
References
24
FWCI
20.70
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis. https://app.cochat.ai/papers/10.1002/art.11181
The paper
Cambridge, G., Leandro, M. J., Edwards, J. C. W., Ehrenstein, M. R., Salden, M., Bodman‐Smith, M., & Webster, A. D. B. (2003). Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.11181

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.