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Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis

Stastny, Peter·1978·New England Journal of Medicine

Abstract

Previous testing of patients with rheumatoid arthritis showed that one HLA-D type, Dw4, occurred more frequently than in normal controls. B-cell alloantigens closely related to HLA-D can now be identified by a simple serologic procedure. Using this test, I studied 80 white patients with erosive, rheumatoid-factor-positive rheumatoid arthritis. The B-cell alloantigen HLA-DRw4 occurred in 70 per cent of 54 patients, as compared to 28 per cent of the 68 normal controls (P less than 10(-5)). Both groups were also tested for the HLA-A, B and C antigens and for HLA-D. HLA-Dw4 occurred in 54 per cent of the patients and 16 per cent of the controls (P less than 10(-5)). Small differences observed in several of the HLA-A and B antigens were not statistically significant. The results indicate that rheumatoid arthritis in whites is associated with genes of the HLA-D region and that immunogenetic factors linked to HLA have a role in its pathogenesis.

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Metadata

Authors
Stastny, P.
Venue
New England Journal of Medicine
Published
1978-04-20
Volume
298
Issue
16
Pages
869-871
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2091943129
Cited by
1,163
References
4
FWCI
38.56
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis. https://app.cochat.ai/papers/10.1056/nejm197804202981602
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Stastny, P. (1978). Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis. New England Journal of Medicine. https://doi.org/10.1056/nejm197804202981602

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