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Bone loss in adults receiving alternate day glucocorticoid therapy
Abstract
Bone mineral content was measured by photon absorption densitometry in 25 patients with rheumatic diseases receiving glucocorticoids on an alternate day treatment schedule, and in 25 age‐, sex‐, and race‐matched patients receiving daily steroid therapy. Mean values for cortical (diaphyseal) mass, trabecular (metaphyseal) mass, and the cortical/trabecular mass ratios were not different in the two groups. Steroid‐induced osteopenia, defined as an elevated ratio of cortical to trabecular mass, occurred in both therapeutic regimens (8 of 25 on alternate day; 11 of 25 on daily). Therefore, bone loss was demonstrable in individuals on alternate day regimens. Serum levels of calcium, ionized calcium, alkaline phosphatase, and parathyroid hormone were similar in the two groups.
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Cited by
Recommendations for the prevention and treatment of glucocorticoid‐induced osteoporosis
American College of Rheumatology task force on Osteoporosis guidelines (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780391104 · Cited by 848
Steroid-Induced Fractures and Bone Loss in Patients with Asthma
Adinoff, A. D., & Hollister, J. R. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308043090502 · Cited by 674
Da Silva, J. A. P., Jacobs, J. W. G., Kirwan, J. R., Boers, M., Saag, K. G., Inês, L. B. S., de Koning, E. J. P., Buttgereit, F., Cutolo, M., Capell, H., et al. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.038638 · Cited by 522
Glucocorticoid osteoporosis--mechanisms and management
Reid, I. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370209 · Cited by 278
Glucocorticoids: Complications to Anticipate and Prevent
Gensler, L. S. (2013) · The Neurohospitalist · doi:10.1177/1941874412458678 · Cited by 100
Metadata
- Authors
- Gluck, O. S., Murphy, W. A., Hahn, T. J., & Hahn, B.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1981-07
- Volume
- 24
- Issue
- 7
- Pages
- 892-898
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2001564937
- Cited by
- 197
- References
- 0
- FWCI
- 10.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gluck, O. S., Murphy, W. A., Hahn, T. J., & Hahn, B. (1981). Bone loss in adults receiving alternate day glucocorticoid therapy. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780240705
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