The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Steroid-Induced Fractures and Bone Loss in Patients with Asthma
Abstract
To study the association between bone disease and long-term steroid administration in asthmatics, we reviewed the hospital records of 128 patients over 40 years of age who had taken daily or alternate-day adrenal corticosteroids for at least a year and compared them with the records of 54 other asthmatics of similar age who had not required long-term administration of steroids. We found evidence in the records of a total of 58 fractures of the ribs or vertebrae in 14 of the patients who had received long-term steroid treatment (11 per cent) and no evidence of fractures in the patients who had not received long-term treatment. We also prospectively studied 30 hospitalized asthmatic patients between 20 and 70 years of age who had been screened for medications (other than steroids) or complicating diseases known to affect bone mineralization. Eight of 19 asthmatic patients receiving long-term steroid therapy had rib or vertebral fractures, whereas none of 11 matched patients not receiving such therapy had fractures. Furthermore, bone-density measurements of the distal and proximal radius by photon absorptiometry revealed that the trabecular, but not the cortical, bone mass was below normal in the former group of patients but not in the latter. Within the long-term steroid group, there was no significant correlation between bone density and dose or duration of steroid treatment. We conclude that long-term steroid therapy in asthmatic patients is associated with decreased trabecular bone density and an increased prevalence of rib and vertebral fractures.
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Cites
Snedecor, G. W., & Cochran, W. G. (1967) · Cited by 6,573
Measurement of Bone Mineral in vivo: An Improved Method
Cameron, J. R., & Sorenson, J. (1963) · Science · doi:10.1126/science.142.3589.230 · Cited by 824
Hahn, T. J., Halstead, L. R., Teitelbaum, S. L., & Hahn, B. H. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109506 · Cited by 399
Prevention of Involutional Bone Loss by Exercise
ALOIA, J. F., COHN, S. H., OSTUNI, J. A., CANE, R., & ELLIS, K. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-3-356 · Cited by 380
Precision and Accuracy of Bone Mineral Determination by Direct Photon Absorptiometry
Cameron, J. R., Mazess, R. B., & Sorenson, J. A. (1968) · Investigative Radiology · doi:10.1097/00004424-196805000-00001 · Cited by 369
Bone loss in adults receiving alternate day glucocorticoid therapy
Gluck, O. S., Murphy, W. A., Hahn, T. J., & Hahn, B. (1981) · Arthritis & Rheumatism · doi:10.1002/art.1780240705 · Cited by 197
Osteoporosis of rheumatoid arthritis: Influence of age, sex and corticosteroids
Saville, P. D., & Kharmosh, O. (1967) · Arthritis & Rheumatism · doi:10.1002/art.1780100504 · Cited by 158
Effect of prolonged bed rest on urinary calcium output.
Issekutz, B., Jr., Blizzard, J. J., Birkhead, N. C., & Rodahl, K. (1966) · Journal of Applied Physiology · doi:10.1152/jappl.1966.21.3.1013 · Cited by 152
VERTEBRAL FRACTURES RESULTING FROM PROLONGED CORTISONE AND CORTICOTROPIN THERAPY
Curtiss, P. H. (1954) · JAMA · doi:10.1001/jama.1954.02950050007002 · Cited by 150
Corticosteroid-Induced Osteopenia
Hahn, T. J. (1978) · Archives of Internal Medicine · doi:10.1001/archinte.1978.03630300050010 · Cited by 141
Cited by
Use of Inhaled Corticosteroids and Risk of Fractures
Van Staa, T. P., Leufkens, H. G. M., & Cooper, C. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.3.581 · Cited by 1,308
The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis
Staa, T. P. V., Staa, T. P. V., Staa, T. P. V., Leufkens, H. G. M., & Cooper, C. (2002) · Osteoporosis International · doi:10.1007/s001980200108 · Cited by 1,294
Use of oral corticosteroids and risk of fractures
Van Staa, T. P., Leufkens, H. G. M., Abenhaim, L., Zhang, B., & Cooper, C. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.993 · Cited by 1,263
Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
Saag, K. G., Emkey, R., Schnitzer, T. J., Brown, J. P., Hawkins, F., Goemaere, S., Thamsborg, G., Liberman, U. A., Delmas, P. D., Malice, M.-P., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807303390502 · Cited by 1,258
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875
Metadata
- Authors
- Adinoff, A. D., & Hollister, J. R.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-08-04
- Volume
- 309
- Issue
- 5
- Pages
- 265-268
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2338308982
- Cited by
- 674
- References
- 13
- FWCI
- 25.84
- Type
- journal article
- Language
- en
- Open access
- closed
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