The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis
Abstract
Twelve patients with active rheumatoid arthritis supplemented their usual diet with 20 gm of Max‐EPA fish oil, daily, for 6 weeks. Following this supplementation, the ratio of arachidonic acid to eicosapentaenoic acid in the patients' neutrophil cellular lipids decreased from 81:1 to 2.7:1, and the mean generation of leukotriene B 4 (with calcium ionophore stimulation) significantly declined by 33%. The mean neutrophil chemotaxis to both leukotriene B 4 and FMLP significantly increased toward the normal range at week 6. The generation of 5‐lipoxygenase products by calcium ionophore‐stimulated monocytes was not significantly suppressed, but a significant decline (37%) in plateletactivating factor generation was noted at week 6. The modulation of these measures of leukocyte inflammatory potential suggests that fish oil supplementation may have an antiinflammatory effect.
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Cites
Lee, T. H., Hoover, R. L., Williams, J. D., Sperling, R. I., Ravalese, J., Spur, B. W., Robinson, D. R., Corey, E. J., Lewis, R. A., & Austen, K. F. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121903 · Cited by 1,333
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Cited by
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525
Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance
Calder, P. C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.010 · Cited by 1,717
Calder, P. C. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108008690 · Cited by 111
Nauroth, J. M., Liu, Y. C., Van Elswyk, M., Bell, R., Hall, E. B., Chung, G., & Arterburn, L. M. (2010) · Lipids · doi:10.1007/s11745-010-3406-3 · Cited by 89
The effect of n-3 fatty acids on neutrophil chemiluminescence
Varming, K., Schmidt, E. B., Svaneborg, N., Møller, J. M., Lervang, H.-H., Grunnet, N., Jersild, C., & Dyerberg, J. (1995) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519509075377 · Cited by 64
Metadata
- Authors
- Sperling, R. I., Weinblatt, M., Robin, J., Iii, J. R., Hoover, R. L., House, F., Coblyn, J. S., Fraser, P. A., Spur, B. W., Robinson, D. R., Lewis, R. A., & Austen, K. F.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1987-09
- Volume
- 30
- Issue
- 9
- Pages
- 988-997
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2076623706
- Cited by
- 209
- References
- 1
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. https://app.cochat.ai/papers/10.1002/art.1780300905
- The paper
- Sperling, R. I., Weinblatt, M., Robin, J., Iii, J. R., Hoover, R. L., House, F., Coblyn, J. S., Fraser, P. A., Spur, B. W., Robinson, D. R., Lewis, R. A., & Austen, K. F. (1987). Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780300905
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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