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Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium
Abstract
The expression of messenger RNA encoding neutral metalloproteinases and the tissue inhibitor of metalloproteinases (TIMP) in human arthritic synovium was evaluated in situ, using RNA probes. Interstitial collagenase and stromelysin were expressed by synovial lining cells in patients with active rheumatoid arthritis (RA). Proteinase messenger RNA was found both in cells expressing mononuclear phagocyte antigens and in cells that were negative for the antigens. TIMP was also expressed predominantly along the synovial lining layer. In highly inflammatory RA, TIMP expression appeared less intense than that of the proteases. In osteoarthritic synovium, TIMP was expressed at easily detectable levels, whereas the expression of collagenase and stromelysin was less prominent. The balance between expression of the metalloproteinases and of the metalloproteinase inhibitor in synovium appears to be altered during inflammation. These results are consistent with the notion that synovium plays different roles in the cartilage damage of RA and of osteoarthritis.
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Cited by
Shapiro, S. D., Kobayashi, D. K., & Ley, T. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80459-1 · Cited by 489
Fallowfield, J. A., Mizuno, M., Kendall, T. J., Constandinou, C. M., Benyon, R. C., Duffield, J. S., & Iredale, J. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5288 · Cited by 479
Stefan Lohmander, L., Neame, P. J., & Sandy, J. D. (1993) · Arthritis & Rheumatism · doi:10.1002/art.1780360906 · Cited by 431
Sandy, J. D., Flannery, C. R., Neame, P. J., & Lohmander, L. S. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115742 · Cited by 411
Active Site Residues of Cyclophilin A Are Crucial for Its Signaling Activity via CD147
Yurchenko, V., Zybarth, G., O'Connor, M., Dai, W. W., Franchin, G., Hao, T., Guo, H., Hung, H.-C., Toole, B., Gallay, P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201593200 · Cited by 334
Metadata
- Authors
- Spence Mccachren, S.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1991-10-07
- Volume
- 34
- Issue
- 9
- Pages
- 1085-1093
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2030256425
- Cited by
- 210
- References
- 0
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spence Mccachren, S. (1991). Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780340904
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