The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Active Site Residues of Cyclophilin A Are Crucial for Its Signaling Activity via CD147
Open accessAbstract
Cyclophilin A (CyPA), a ubiquitously distributed intracellular protein, is a peptidylprolyl cis-trans-isomerase and the major target of the potent immunosuppressive drug cyclosporin A. Although expressed predominantly as an intracellular molecule, CyPA is secreted by cells in response to inflammatory stimuli and is a potent neutrophil and eosinophil chemoattractant in vitro and in vivo. The mechanisms underlying CyPA-mediated signaling and chemotaxis are unknown. Here, we identified CD147 as a cell surface receptor for CyPA and demonstrated that CD147 is an essential component in the CyPA-initiated signaling cascade that culminates in ERK activation. Both signaling and chemotactic activities of CyPA depended also on the presence of heparans, which served as primary binding sites for CyPA on target cells. The proline 180 and glycine 181 residues in the extracellular domain of CD147 were critical for signaling and chemotactic activities mediated by CD147. Also crucial were active site residues of CyPA, because rotamase-defective CyPA mutants failed to initiate signaling events. These results establish cyclophilins as natural ligands for CD147 and suggest an unusual, rotamase-dependent mechanism of signaling.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES
Boyden, S. (1962) · The Journal of Experimental Medicine · doi:10.1084/jem.115.3.453 · Cited by 2,733
Rheumatoid Arthritis: Pathophysiology and Implications for Therapy
Epstein, F. H., & Harris, E. D. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005033221805 · Cited by 1,551
T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ
Tanaka, Y., Adams, D. H., Hubscher, S., Hirano, H., Siebenlist, U., & Shaw, S. (1993) · Nature · doi:10.1038/361079a0 · Cited by 873
Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B
Luban, J., Bossolt, K. L., Franke, E. K., Kalpana, G. V., & Goff, S. P. (1993) · Cell · doi:10.1016/0092-8674(93)90637-6 · Cited by 802
Sequence identification of 2,375 human brain genes
Adams, M. D., Dubnick, M., Kerlavage, A. R., Moreno, R., Kelley, J. M., Utterback, T. R., Nagle, J. W., Fields, C., & Venter, J. C. (1992) · Nature · doi:10.1038/355632a0 · Cited by 757
Biswas, C., Zhang, Y., DeCastro, R., Guo, H., Nakamura, T., Kataoka, H., & Nabeshima, K. (1995) · PubMed · Cited by 716
Self-citationCrystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid
Gamble, T. R., Vajdos, F. F., Yoo, S., Worthylake, D. K., Houseweart, M., Sundquist, W. I., & Hill, C. P. (1996) · Cell · doi:10.1016/s0092-8674(00)81823-1 · Cited by 706
Firestein, G. S. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780391103 · Cited by 591
Kofron, J. L., Kuzmic, P., Kishore, V., Colon-Bonilla, E., & Rich, D. H. (1991) · Biochemistry · doi:10.1021/bi00239a007 · Cited by 507
Cyclophilin A Is a Secreted Growth Factor Induced by Oxidative Stress
Jin, Z.-G., Melaragno, M. G., Liao, D.-F., Yan, C., Haendeler, J., Suh, Y.-A., Lambeth, J. D., & Berk, B. C. (2000) · Circulation Research · doi:10.1161/01.res.87.9.789 · Cited by 398
Cited by
Muramatsu, T., & Miyauchi, T. (2003) · PubMed · doi:10.14670/hh-18.981 · Cited by 277
Cyclophilin A/CD147 Interaction: A Promising Target for Anticancer Therapy
Han, J. M., & Jung, H. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169341 · Cited by 75
Metadata
- Authors
- Yurchenko, V., Zybarth, G., O'Connor, M., Dai, W. W., Franchin, G., Hao, T., Guo, H., Hung, H.-C., Toole, B., Gallay, P., Sherry, B., & Bukrinsky, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 277
- Issue
- 25
- Pages
- 22959-22965
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2138681651
- Cited by
- 334
- References
- 39
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Active Site Residues of Cyclophilin A Are Crucial for Its Signaling Activity via CD147. https://app.cochat.ai/papers/10.1074/jbc.m201593200
- The paper
- Yurchenko, V., Zybarth, G., O'Connor, M., Dai, W. W., Franchin, G., Hao, T., Guo, H., Hung, H.-C., Toole, B., Gallay, P., Sherry, B., & Bukrinsky, M. (2002). Active Site Residues of Cyclophilin A Are Crucial for Its Signaling Activity via CD147. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m201593200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
