The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin‐4 in an ex vivo model of rheumatoid synovitis
Abstract
Objective. To assess the spontaneous production of proinflammatory cytokines and immunoglobulins in rheumatoid arthritis (RA) synovitis and modulation by interleukin‐4 (IL‐4). Methods. We developed an ex vivo model of RA synovitis using pieces of RA synovium, and have studied the regulation of the production of IL‐1β, IL‐6, tumor necrosis factor α (TNFα), IgM, and IgG. Results. Spontaneous production of proinflammatory cytokines in vitro was active, with prolonged cytokine gene transcription and translation. IL‐6 was produced at higher levels than either IL‐1β or TNFα, and explants produced more IgG than IgM. In contrast, IL‐4 and interferon‐γ were undetectable. When pieces of synovium were incubated in the presence of IL‐4, reduction of spontaneous proinflammatory cytokine and Ig production was observed. Conclusion. These results extend the observations of the antiinflammatory properties of IL‐4 to an ex vivo situation, and provide the rationale for the clinical use of IL‐4 in RA.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
IL‐4 directs the development of Th2‐like helper effectors
Swain, S. L., Weinberg, A. D., English, M., & Huston, G. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.11.3796 · Cited by 1,254
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Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
Chabaud, M., Durand, J. M., Buchs, N., Fossiez, F., Page, G., Frappart, L., & Miossec, P. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199905)42:5<963::aid-anr15>3.0.co;2-e · Cited by 954
Self-citationChabaud, M., Fossiez, F., Taupin, J.-L., & Miossec, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.409 · Cited by 457
Self-citationAnti-inflammatory mechanisms of methotrexate in rheumatoid arthritis
CUTOLO, M., SULLI, A., PIZZORNI, C., SERIOLO, B., & STRAUB, R. H. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.8.729 · Cited by 433
Chabaud, M., Lubberts, E., Joosten, L., van den Berg, W., & Miossec, P. (2001) · Arthritis Research & Therapy · doi:10.1186/ar294 · Cited by 333
Self-citationLubberts, E., Joosten, L. A. B., Chabaud, M., van den Bersselaar, L., Oppers, B., Coenen-de Roo, C. J. J., Richards, C. D., Miossec, P., & van den Berg, W. B. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7739 · Cited by 309
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Metadata
- Authors
- Miossec, P., Briolay, J., Dechanet, J., Wijdenes, J., Martinez‐Valdez, H., & Banchereau, J.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1992-08
- Volume
- 35
- Issue
- 8
- Pages
- 874-883
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2005324550
- Cited by
- 185
- References
- 2
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Miossec, P., Briolay, J., Dechanet, J., Wijdenes, J., Martinez‐Valdez, H., & Banchereau, J. (1992). Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin‐4 in an ex vivo model of rheumatoid synovitis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780350805
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