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Cited by 728Osteoarthritis Treatment and MechanismsMusculoskeletal pain and rehabilitationHip disorders and treatments

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study

Felson, David T., Zhang, Yuqing, Hannan, Marian T., Naimark, Allan, Weissman, Barbara N., Aliabadi, Piran, Levy, Daniel·1995·Arthritis & Rheumatism
DOI 10.1002/art.1780381017
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Abstract

OBJECTIVE: To determine the incidence of radiographic knee osteoarthritis (OA) and symptomatic OA (symptoms plus radiographic OA), as well as the rate of progression of preexisting radiographic OA in a population-based sample of elderly persons. METHODS: Framingham Osteoarthritis Study subjects who had knee radiographs and had answered questions about knee symptoms in 1983-1985 were reexamined in 1992-1993 (mean 8.1-year interval) using the same protocol. Subjects were defined as having new (incident) radiographic OA if they developed grade > or = 2 OA (at least definite osteophytes or definite joint space narrowing). New symptomatic OA was present if subjects developed a combination of knee symptoms and grade > or = 2 OA. Progressive OA was diagnosed when radiographs showing grade 2 disease at baseline showed grade > or = 3 disease on followup. RESULTS: Of 1,438 participants in the original study, 387 (26.9%) died prior to followup. Of the 1,051 surviving subjects, 869 (82.7%) participated in the followup study (mean +/- SD age 70.8 +/- 5.0 at baseline). Rates of incident disease were 1.7 times higher in women than in men (95% confidence interval [CI] 1.0-2.7), and progressive disease occurred slightly more often in women (relative risk = 1.4; 95% CI 0.8-2.5) but rates did not vary by age in this sample. Among women, approximately 2% per year developed incident radiographic disease, 1% per year developed symptomatic knee OA, and about 4% per year experienced progressive knee OA. CONCLUSION: In elderly persons, the new onset of knee OA is frequent and is more common in women than men. However, among the elderly, age may not affect new disease occurrence or progression.

Overview

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Crossref · 10.1002/art.1780381017

Cites

12 of 12 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • A toe out stance promotes a greater degree of hip external rotation and gluteal activation, thereby minimizing the potential for impingement.

    “A toe out stance also should be considered as this will promote a greater degree of hip external rotation and gluteal activation, thereby minimizing the potential for impingment.54,58”

    From A Biomechanical Review of the Squat Exercise: Implications for Clinical Practice. (2024) · cites this paper as [58]

Citations

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Research works printed but not linked: 1

  1. SchoutenJSAG:The incidence of risk factors of radiographic osteoarthritis of the knee in the general population. In A Twelve Year Follow‐up Study on Osteoarthritis of the Knee in the General Population (thesis). Rotterdam the Netherlands Erasmus University 1990

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Metadata

Authors
Felson, D. T., Zhang, Y., Hannan, M. T., Naimark, A., Weissman, B. N., Aliabadi, P., & Levy, D.
Affiliations
  • Boston University (US)
  • Brigham and Women's Hospital (US)
  • Framingham Heart Study (US)
Corresponding author
Felson, David T.
ORCID
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
1995-10
Volume
38
Issue
10
Pages
1500-1505
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/art.1780381017
OpenAlex
W2058356008
Cited by
728
References
12
Citations by year
2026: 8 · 2025: 10 · 2024: 13 · 2023: 23 · 2022: 22 · 2021: 34 · 2020: 35 · 2019: 22 · 2018: 33 · 2017: 28 · 2016: 34 · 2015: 32 · 2014: 47 · 2013: 37 · 2012: 33
FWCI
4.43
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3722 d)
Locations
  • Arthritis & Rheumatism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG09300, R01AG009300)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-20613, P60AR020613)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Surgery › Hip disorders and treatments
Keywords
knee osteoarthritis, incidence, disease progression, natural history (disease), older adults, sex differences, symptomatic osteoarthritis, radiographic osteoarthritis, age effects
MeSH terms
Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Knee Joint, Longitudinal Studies, Male, Middle Aged, Osteoarthritis, Radiography, Sex Factors, Cohort Studies, Incidence

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