The DOI matches its Crossref record.
Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The rotterdam study
Abstract
Objective. To investigate the relationship of osteoarthritis (OA) to bone mineral density (BMD) and rate of bone loss. Methods. The study group consisted of 2,745 persons (1,624 women) from the general elderly population. Disability was assessed by the Health Assessment Questionnaire. Femoral neck BMD was measured at baseline and, in 1,723 subjects, after 2 years of followup. Knee and hip radiographic OA was assessed on anteroposterior radiographs. Results. With the exception of knee radiographic OA in men, radiographic OA was associated with significantly increased BMD (3–8%). BMD increased significantly according to the number of affected sites and the Kellgren score. Radiographic OA was also associated with significantly elevated bone loss with age (in men, only for radiographic OA of the hip). A significant increase in relation to the number of affected sites and the Kellgren score (except with regard to knee OA in men) was found, independent of disability. Conclusion. Radiographic OA is associated with higher BMD and increased rate of bone loss. This suggests a more pronounced difference in BMD earlier in life.
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Cited by
Vane, J. R., Bakhle, Y. S., & Botting, R. M. (1998) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.97 · Cited by 2,734
Murphy, J. M., Dixon, K., Beck, S., Fabian, D., Feldman, A., & Barry, F. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10118 · Cited by 527
Garnero, P., Piperno, M., Gineyts, E., Christgau, S., Delmas, P. D., & Vignon, E. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.6.619 · Cited by 475
Osteoarthritis and osteoporosis: Clinical and research evidence of inverse relationship
Dequeker, J., Aerssens, J., & Luyten, F. P. (2003) · Aging Clinical and Experimental Research · doi:10.1007/bf03327364 · Cited by 269
Metadata
- Authors
- Burger, H., van Daele, P. L. A., Odding, E., Valkenburg, H. A., Hofman, A., Grobbee, D. E., Schütte, H. E., Birkenhäger, J. C., & Pols, H. A. P.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1996-01
- Volume
- 39
- Issue
- 1
- Pages
- 81-86
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2039319793
- Cited by
- 268
- References
- 0
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burger, H., van Daele, P. L. A., Odding, E., Valkenburg, H. A., Hofman, A., Grobbee, D. E., Schütte, H. E., Birkenhäger, J. C., & Pols, H. A. P. (1996). Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The rotterdam study. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780390111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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