Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage

Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.

Bellamy, N., Buchanan, W. W., Goldsmith, C. H., Campbell, J., & Stitt, L. (1988) · PubMed · Cited by 7,688 · see citing works

Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee

Altman, R., Asch, E., Bloch, D., Bole, G., Borenstein, D., Brandt, K., Christy, W., Cooke, T. D., Greenwald, R., Hochberg, M., et al. (1986) · Arthritis & Rheumatism · doi:10.1002/art.1780290816 · Cited by 6,777 · see citing works

Models for Longitudinal Data: A Generalized Estimating Equation Approach

Zeger, S. L., Liang, K., & Albert, P. S. (1988) · Biometrics · doi:10.2307/2531734 · Cited by 4,505 · see citing works

Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis

Garnero, P., Sornay‐Rendu, E., Chapuy, M. C., & Delmas, P. D. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110307 · Cited by 1,000 · see citing works

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C. H., Mitchell, P. G., Hambor, J., Diekmann, O., Tschesche, H., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119316 · Cited by 970 · see citing works

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.

Hakala, B. E., White, C., & Recklies, A. D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74461-5 · Cited by 643 · see citing works

Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.

Hollander, A. P., Heathfield, T. F., Webber, C. A., Iwata, Y., Bourne, R., Rorabeck, C. H., & Poole, A. R. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117156 · Cited by 611 · see citing works

ROLE OF MECHANICAL FACTORS IN PATHOGENESIS OF PRIMARY OSTEOARTHRITIS

Radin, E., Paul, I., & Rose, R. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90179-1 · Cited by 595 · see citing works

Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy.

Dieppe, P. A., Cushnaghan, J., Young, P. J., & Kirwan, J. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.8.557 · Cited by 428 · see citing works

Low‐level increases in serum C‐reactive protein are present in early osteoarthritis of the knee and predict progressive disease

Spector, T. D., Hart, D. J., Nandra, D., Doyle, D. V., Mackillop, N., Gallimore, J. R., & Pepys, M. B. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400419 · Cited by 403 · see citing works

Rapid equilibrium radioimmunoassay for the amino-terminal propeptide of human type III procollagen.

Risteli, J., Niemi, S., Trivedi, P., Mäentausta, O., Mowat, A. P., & Risteli, L. (1988) · Clinical Chemistry · doi:10.1093/clinchem/34.4.715 · Cited by 336 · see citing works

Immunoassay for quantifying type I collagen degradation products in urine evaluated

Bonde, M., Qvist, P., Fledelius, C., Riis, B. J., & Christiansen, C. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.11.2022 · Cited by 323 · see citing works

Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen

Rosenquist, C., Fledelius, C., Christgau, S., Pedersen, B. J., Bonde, M., Qvist, P., & Christiansen, C. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.11.2281 · Cited by 317 · see citing works

Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

Dodge, G. R., & Poole, A. R. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113929 · Cited by 295 · see citing works

Collagen type II C-telopeptide fragments as an index of cartilage degradation

Christgau, S., Garnero, P., Fledelius, C., Moniz, C., Ensig, M., Gineyts, É., Rosenquist, C., & Qvist, P. (2001) · Bone · doi:10.1016/s8756-3282(01)00504-x · Cited by 285 · see citing works

Reliability of new indices of radiographic osteoarthritis of the hand and hip and lumbar disc degeneration.

Lane, N. E., Nevitt, M. C., Genant, H. K., & Hochberg, M. C. (1993) · PubMed · Cited by 276 · see citing works

Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The rotterdam study

Burger, H., van Daele, P. L. A., Odding, E., Valkenburg, H. A., Albert Hofman, D., Grobbee, D. E., Schütte, H. E., Birkenhäger, J. C., & Pols, H. A. P. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390111 · Cited by 270 · see citing works

Markers of Bone Turnover Predict Postmenopausal Forearm Bone Loss Over 4 Years: The OFELY Study

Garnero, P., Sornay‐Rendu, E., Duboeuf, F., & Delmas, P. D. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.9.1614 · Cited by 253 · see citing works

Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism.

Månsson, B., Carey, D. E., Alini, M., Ionescu, M., Rosenberg, L. C., Poole, A. R., Heinegård, D. K., & Saxne, T. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117753 · Cited by 247 · see citing works

Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study.

Zhang, Y., Hannan, M. T., Chaisson, C. E., McAlindon, T. E., Evans, S. R., Aliabadi, P., Levy, D. A., & Felson, D. T. (2000) · PubMed · Cited by 246 · see citing works

Urinary hydroxy-pyridinium crosslinks provide indices of cartilage and bone involvement in arthritic diseases.

Seibel, M. J., Duncan, A., & Robins, S. P. (1989) · PubMed · Cited by 213 · see citing works

Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: Results of a multicenter, randomized, controlled trial

Ravaud, P., Moulinier, L., Giraudeau, B., Ayral, X., Guérin, C., Noël, É., Thomas, P., Fautrel, B., Mazières, B., & Dougados, M. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199904)42:3 · Cited by 212 · see citing works

RELATIONSHIP BETWEEN SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN LEVELS AND DISEASE PROGRESSION IN OSTEOARTHRITIS OF THE KNEE JOINT

SHARIF, M., Saxne, T., Shepstone, L., Kirwan, J., Elson, C. J., Heinegård, D. K., & Dieppe, P. A. (1995) · Lara D. Veeken · doi:10.1093/rheumatology/34.4.306 · Cited by 204 · see citing works

Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint

Petersson, I. F., Boegård, T., Svensson, B., Heinegård, D. K., & Saxne, T. (1998) · Lara D. Veeken · doi:10.1093/rheumatology/37.1.46 · Cited by 196 · see citing works

Measurement of serum osteocalcin with a human-specific two-site immunoradiometric assay

Garnero, P., Grimaux, M., Demiaux, B., Préaudat, C., Seguin, P., & Delmas, P. D. (1992) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650071206 · Cited by 182 · see citing works

Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee

Sharif, M., George, E., Shepstone, L., Knudson, W., Thonar, E. J. ‐. A., Cushnaghan, J., & Dieppe, P. A. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380608 · Cited by 169 · see citing works

SERUM YKL-40 LEVELS IN HEALTHY CHILDREN AND ADULTS. COMPARISON WITH SERUM AND SYNOVIAL FLUID LEVELS OF YKL-40 IN PATIENTS WITH OSTEOARTHRITIS OR TRAUMA OF THE KNEE JOINT

Johansen, J. S., Hvolris, J., HANSEN, M., Backer, V., Lorenzen, I., & Price, P. A. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.6.553 · Cited by 163 · see citing works

Quantificative evaluation of joint space width in femorotibal osteoarthritis: comparison of three radiographic views

Piperno, M., Graverand, M. H. L., Conrozier, T., Bochu, M., Mathieu, P., & Vignon, E. P. (1998) · Osteoarthritis and Cartilage · doi:10.1053/joca.1998.0118 · Cited by 159 · see citing works

Osteoarthritis, bone density, postural stability, and osteoporotic fractures: a population based study.

Jones, G., Nguyen, T. V., Sambrook, P. N., Lord, S. R., Kelly, P. J., & Eisman, J. A. (1995) · PubMed · Cited by 144 · see citing works

COMP (Cartilage Oligomeric Matrix Protein) is Synthesized in Ligament, Tendon, Meniscus, and Articular Cartilage

Müller, G., Michel, A., & Altenburg, E. (1998) · Connective Tissue Research · doi:10.3109/03008209809021499 · Cited by 141 · see citing works

Cross-sectional assessment of age-related bone loss in men: the MINOS study

Szulc, P., Marchand, F., Duboeuf, F., & Delmas, P. D. (2000) · Bone · doi:10.1016/s8756-3282(99)00255-0 · Cited by 137 · see citing works

Measurement of the cross linking compound, pyridinoline, in urine as an index of collagen degradation in joint disease.

Robins, S. P., Stewart, P., Astbury, C., & Bird, H. A. (1986) · Annals of the Rheumatic Diseases · doi:10.1136/ard.45.12.969 · Cited by 119 · see citing works

INVERSE RELATIONSHIP OSTEOARTHRITIS—OSTEOPOROSIS: WHAT IS THE EVIDENCE? WHAT ARE THE CONSEQUENCES?

Dequeker, J., Boonen, S., Aerssens, J., & Westhovens, R. (1996) · Lara D. Veeken · doi:10.1093/rheumatology/35.9.813 · Cited by 111 · see citing works

A chimeric antibody with the human ?1 constant region as a putative standard for assays to detect IgG ?2-glycoprotein I-dependent anticardiolipin and anti-?2-glycoprotein I antibodies

Ichikawa, K., Tsutsumi, A., Atsumi, T., Matsuura, E., Kobayashi, S., Hughes, G. R. V., Khamashta, M. A., & Koike, T. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199911)42:11 · Cited by 88 · see citing works

Variability in knee radiographing: implication for definition of radiological progression in medial knee osteoarthritis

Ravaud, P., Giraudeau, B., Auleley, G.-R., Drapé, J., Rousselin, B., Paolozzi, L., Chastang, C., & Dougados, M. (1998) · Annals of the Rheumatic Diseases · doi:10.1136/ard.57.10.624 · Cited by 88 · see citing works

Musculoskeletal disease research: should we analyze the joint or the person?

Zhang, Y., Glynn, R. J., & Felson, D. T. (1996) · PubMed · Cited by 86 · see citing works

Bone density and bone turnover in patients with osteoarthritis and osteoporosis.

Stewart, A. D., Black, A. J., Robins, S. P., & Reid, D. M. (1999) · PubMed · Cited by 85 · see citing works

Morphologic alterations of the subchondral bone in advanced degenerative arthritis.

MILGRAM, J. W. (1983) · PubMed · Cited by 84 · see citing works

Morphologic Alterations of the Subchondrall Bone in Advanced Degenerative Arthritis

MILGRAM, J. W. (1983) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198303000-00039 · Cited by 68 · see citing works

Bone mineral density and bone turnover in spinal osteoarthrosis.

Peel, N. F. A., Barrington, N. A., Blumsohn, A., Colwell, A., Hannon, R. A., & Eastell, R. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.11.867 · Cited by 65 · see citing works

URINARY EXCRETION OF PYRIDINIUM CROSSLINKS OF COLLAGEN CORRELATED WITH JOINT DAMAGE IN ARTHRITIS

ASTBURY, C., Bird, H. A., McLaren, A., & Robins, S. P. (1994) · Lara D. Veeken · doi:10.1093/rheumatology/33.1.11 · Cited by 59 · see citing works

Urinary excretion of glucosyl‐galactosyl pyridinoline: a specific biochemical marker of synovium degradation

Gineyts, É., Garnero, P., & Delmas, P. D. (2001) · Lara D. Veeken · doi:10.1093/rheumatology/40.3.315 · Cited by 57 · see citing works

Detection of cellular microchimerism of male or female origin in systemic sclerosis patients by polymerase chain reaction analysis of HLA–Cw antigens

Artlett, C. M., Cox, L. A., & Jiménez, S. A. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200005)43:5 · Cited by 56 · see citing works

Subchondral bone morphological and biochemical alterations in osteoarthritis

Lajeunesse, D., Hilal, G., Pelletier, J., & Martel‐Pelletier, J. (1999) · Osteoarthritis and Cartilage · doi:10.1053/joca.1998.0180 · Cited by 53 · see citing works

Immunochemical markers of joint inflammation, skeletal damage and repair: where are we now?

Poole, A. R. (1994) · Annals of the Rheumatic Diseases · doi:10.1136/ard.53.1.3 · Cited by 53 · see citing works

URINARY COLLAGEN CROSSLINKS REFLECT THE RADIOGRAPHIC SEVERITY OF KNEE OSTEOARTHRITIS

Thompson, P. W., Spector, T. D., James, I., HENDERSON, E., & Hart, D. J. (1992) · Lara D. Veeken · doi:10.1093/rheumatology/31.11.759 · Cited by 52 · see citing works

Bone Mineral Density and Bone Turnover in Patients with Knee Osteoarthritis Compared with Generalized Osteoarthritis

Naitou, K., KUSHIDA, K., Takahashi, M., Ohishi, T., & Inoue, T. M. N. (2000) · Calcified Tissue International · doi:10.1007/s002230010068 · Cited by 43 · see citing works

Increased levels of type I and III collagen and hyaluronan in scleroderma skin

SOSNDERGAARD, K., Heickendorff, L., Risteli, L., Risteli, J., ZACHARIAE, H., STENGAARD-PEDERSHN, K., & Deleuran, B. W. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.d01-1141.x · Cited by 42 · see citing works

Concentrations of pyridinoline and deoxypyridinoline in joint tissues from patients with osteoarthritis or rheumatoid arthritis.

Takahashi, M., KUSHIDA, K., Hoshino, H., Suzuki, M., Sano, M., Miyamoto, S., & Inoue, T. M. N. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.5.324 · Cited by 42 · see citing works

SERUM AND SYNOVIAL FLUID OSTEOCALCIN (BONE GLA PROTEIN) LEVELS IN JOINT DISEASE

Campion, G., Delmas, P. D., & Dieppe, P. A. (1989) · Lara D. Veeken · doi:10.1093/rheumatology/28.5.393 · Cited by 40 · see citing works

ASSESSMENT OF URINARY HYDROXYPYRIDINIUM CROSS-LINKS MEASUREMENT IN OSTEOARTHRITIS

Graverand, M.-P. H. L., Tron, A.-M., ICHOU, M., DALLARD, M. C., Richard, M., Uebelhart, D., & Vignon, E. P. (1995) · Lara D. Veeken · doi:10.1093/rheumatology/35.11.1091 · Cited by 26 · see citing works

Defining and validating the clinical role of molecular markers in osteoarthritis

Lohmander, S. L., & Poole, A. R. (2003) · Lund University Publications (Lund University) · Cited by 22 · see citing works

Synovial fluid and serum concentrations of aminoterminal propeptide of type III procollagen in healthy volunteers and patients with joint disease.

Sharif, M., George, E., & Dieppe, P. A. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.1.47 · Cited by 18 · see citing works

Bone mineral density and bone turnover in spinal osteoarthritis.

Dequeker, J., & Mbuyi-Muamba, J. M. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.5.331-a · Cited by 13 · see citing works

Connective tissue markers of rheumatoid arthritis

Møller, H. J. (1998) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365519850186445 · Cited by 9 · see citing works

Untitled work

Lawrence (1998) · doi:10.1002/1529-0131(199805)41:5

Untitled work

Wilson (1999) · doi:10.1002/1529-0131(199907)42:7

Osteoarthritis

Glyn-Jones, S., Palmer, A. J. R., Agricola, R., Price, A. J., Vincent, T. L., Weinans, H., & Carr, A. J. (2015) · The Lancet · doi:10.1016/s0140-6736(14)60802-3 · Cited by 3,151 · see citing works

Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury

Lee, C. G., Da Silva, C. A., Dela Cruz, C. S., Ahangari, F., Ma, B., Kang, M.-J., He, C.-H., Takyar, S., & Elias, J. A. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142250 · Cited by 896 · see citing works

Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2010

Fürst, D. E., Keystone, E. C., Braun, J., Breedveld, F. C., Burmester, G. R., Benedetti, F. D., Dorner, T. E., Emery, P., Fleischmann, R., Gibofsky, A., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.146852 · Cited by 691 · see citing works

Depression in Rheumatoid Arthritis: A Systematic Review of the Literature With Meta-Analysis

Dickens, C. M., McGowan, L., Clark-Carter, D. D., & Creed, F. H. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200201000-00008 · Cited by 635 · see citing works

Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer.

Johansen, J. S. (2006) · PubMed · Cited by 404 · see citing works

Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis

Garnero, P., Ayral, X., Rousseau, J., Christgau, S., Sandell, L. J., Dougados, M., & Delmas, P. D. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10576 · Cited by 395 · see citing works

Value of biomarkers in osteoarthritis: current status and perspectives

Lotz, M., Martel-Pelletier, J., Christiansen, C., Brandi, M.-L., Bruyère, O., Chapurlat, R., Collette, J., Cooper, C., Giacovelli, G., Kanis, J. A., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203726 · Cited by 328 · see citing works

Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown

Ding, C., Garnero, P., Cicuttini, F., Scott, F. S., Cooley, H. M., & Jones, G. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2004.11.007 · Cited by 322 · see citing works

Effect of Acupuncture vs Sham Acupuncture or Waitlist Control on Joint Pain Related to Aromatase Inhibitors Among Women With Early-Stage Breast Cancer

Hershman, D. L., Unger, J. M., Greenlee, H., Capodice, J. L., Lew, D. L., Darke, A. K., Kengla, A. T., Melnik, M. K., Jorgensen, C. W., Kreisle, W. H., et al. (2018) · JAMA · doi:10.1001/jama.2018.8907 · Cited by 301 · see citing works

Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis

Jin, X., Beguerie, J. R., Zhang, W., Blizzard, L., Otáhal, P., Jones, G., & Ding, C. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204494 · Cited by 282 · see citing works

Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application

Høegh-Andersen, P., Tankó, L. B., Andersen, T. L., Lundberg, C. V., Mo, J., Heegaard, A., Delaissé, J., & Christgau, S. (2004) · Arthritis Research & Therapy · doi:10.1186/ar1152 · Cited by 260 · see citing works

Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes

Raynauld, J., Martel‐Pelletier, J., Berthiaume, M.-J., Beaudoin, G., Choquette, D., Haraoui, B. P., Tannenbaum, H., Meyer, J. M., Beary, J. F., Cline, G. A., et al. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1875 · Cited by 258 · see citing works

A new marker for osteoarthritis: Cross‐sectional and longitudinal approach

Reijman, M., Hazes, J. M. W., Bierma-Zeinstra, S., Koes, B. W., Christgau, S., Christiansen, C., Uitterlinden, A. G., & Pols, H. A. P. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20332 · Cited by 255 · see citing works

Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models

Eitner, A., Hofmann, G., & Schaible, H. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00349 · Cited by 229 · see citing works

Articular Cartilage: Injury Pathways and Treatment Options

Simon, T. M., & Jackson, D. W. (2018) · Sports Medicine and Arthroscopy Review · doi:10.1097/jsa.0000000000000182 · Cited by 233 · see citing works

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized

Hunter, D. J., Gerstenfeld, L., Bishop, G., Davis, A. D., Mason, Z. D., Einhorn, T. A., Maciewicz, R. A., Newham, P., Foster, M., Jackson, S., et al. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2601 · Cited by 214 · see citing works

YKL-40 Expression is Associated with Poorer Response to Radiation and Shorter Overall Survival in Glioblastoma

Pelloski, C. E., Mahajan, A., Maor, M. H., Chang, E. L., Woo, S. Y., Gilbert, M. R., Colman, H., Yang, H. W., Ledoux, A. A., Blair, H. E., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1765 · Cited by 207 · see citing works

Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee

Lewis, J. S., Hembree, W. C., Furman, B. D., Tippets, L., Cattel, D., Huebner, J. L., Little, D., DeFrate, L. E., Kraus, V. B., Guilak, F., et al. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.04.011 · Cited by 201 · see citing works

NLRP3 as a potentially novel biomarker for the management of osteoarthritis

McAllister, M. J., Chemaly, M., Eakin, A., Gibson, D. S., & McGilligan, V. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.02.901 · Cited by 201 · see citing works

Biological markers in osteoarthritis

Rousseau, J.-C., & Delmas, P. D. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0508 · Cited by 237 · see citing works

Osteoarthritis: Cellular and molecular changes in degenerating cartilage

Lorenz, H. ‐., & Richter, W. (2006) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2006.02.003 · Cited by 179 · see citing works

Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index

Mouritzen, U., Christgau, S., Lehmann, H.-J., Tankó, L. B., & Christiansen, C. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.4.332 · Cited by 169 · see citing works

Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review

Dainese, P., Wyngaert, K. V., Mits, S. D., Wittoek, R., Ginckel, A. V., & Calders, P. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.12.003 · Cited by 167 · see citing works

Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis

Kong, S., Stäbler, T., Criscione‐Schreiber, L. G., Elliott, A. L., Jordan, J. M., & Kraus, V. B. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21977 · Cited by 162 · see citing works

Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis

Matyas, J. R., Atley, L. M., Ionescu, M., Eyre, D. R., & Poole, A. R. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20027 · Cited by 158 · see citing works

Inflammatory markers and physical function among older adults with knee osteoarthritis.

Penninx, B. W. J. H., Abbas, H., Ambrosius, W. T., Nicklas, B. J., Davis, C., Messier, S. P., & Pahor, M. (2004) · PubMed · Cited by 154 · see citing works

Articular Cartilage: Injury Pathways and Treatment Options

Simon, T. M., & Jackson, D. W. (2006) · Sports Medicine and Arthroscopy Review · doi:10.1097/00132585-200609000-00006 · Cited by 149 · see citing works

The role of obesity and adipose tissue dysfunction in osteoarthritis pain

Binvignat, M., Sellam, J., Berenbaum, F., & Felson, D. T. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01143-3 · Cited by 147 · see citing works

Chitinase 3-Like-1 (CHI3L1): A Putative Disease Marker at the Interface of Proteomics and Glycomics

Coffman, F. D. (2008) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360802334743 · Cited by 146 · see citing works

Biological markers in osteoarthritis

Rousseau, J., & Garnero, P. (2012) · Bone · doi:10.1016/j.bone.2012.04.001 · Cited by 156 · see citing works

The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials

Wang, X., Hunter, D. J., Jin, X., & Ding, C. (2017) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2017.11.015 · Cited by 141 · see citing works

New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis

Deberg, M. A., Labasse, A., Christgau, S., Cloos, P. A., Henriksen, D. B., Jp, C., Zegels, B., Reginster, J., & Henrotin, Y. E. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2004.12.002 · Cited by 141 · see citing works

Association of biomarkers with pre–radiographically defined and radiographically defined knee osteoarthritis in a population‐based study

Cibere, J., Zhang, H., Garnero, P., Poole, A. R., Lobanok, T., Saxne, T., Kraus, V. B., Way, A., Thorne, A., Wong, H., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24473 · Cited by 140 · see citing works

Design and conduct of clinical trials in patients with osteoarthritis of the hand: recommendations from a task force of the Osteoarthritis Research Society International

Maheu, E., Altman, R. D., Bloch, D. A., Doherty, M., Hochberg, M. C., Mannoni, A., Punzi, L., Spector, T. D., & Verbruggen, G. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.02.010 · Cited by 137 · see citing works

Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis

Nguyen, L., Sharma, A. R., Chakraborty, C., Saibaba, B., Ahn, M., & Lee, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030601 · Cited by 134 · see citing works

Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation

Kuttapitiya, A., Assi, L., Laing, K. G., Hing, C. B., Mitchell, P., Whitley, G. S. J., Harrison, A., Howe, F. A., Ejindu, V., Heron, C. W., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211396 · Cited by 134 · see citing works

Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM)

Christgau, S., Tankó, L. B., Cloos, P. A., Mouritzen, U., Christiansen, C., Delaissé, J., & Høegh-Andersen, P. (2004) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.wcb.0000121484.18437.98 · Cited by 132 · see citing works

Association between biomarkers of tissue inflammation and progression of osteoarthritis: evidence from the Rotterdam study cohort

Hosnijeh, F. S., Siebuhr, A. S., Uitterlinden, A. G., Oei, E. H. G., Albert Hofman, D., Karsdal, M. A., Bierma‐Zeinstra, S., Bay‐Jensen, A., & van Meurs, J. B. J. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-0976-3 · Cited by 126 · see citing works

Changes in Cytokines and Aggrecan ARGS Neoepitope in Synovial Fluid and Serum and in C‐Terminal Crosslinking Telopeptide of Type II Collagen and N‐Terminal Crosslinking Telopeptide of Type I Collagen in Urine Over Five Years After Anterior Cruciate Ligament Rupture: An Exploratory Analysis in the Knee Anterior Cruciate Ligament, Nonsurgical Versus Surgical Treatment Trial

Struglics, A., Larsson, S., Kumahashi, N., Frobell, R. B., & Lohmander, S. L. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39146 · Cited by 125 · see citing works

Biomarkers in osteoarthritis

Garnero, P., & Delmas, P. D. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200309000-00020 · Cited by 120 · see citing works

Serum cartilage oligomeric matrix protein (sCOMP) is elevated in patients with knee osteoarthritis: a systematic review and meta-analysis

Hoch, J. M., Mattacola, C. G., McKeon, J. M. M., Howard, J. S., & Lattermann, C. M. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.09.005 · Cited by 118 · see citing works

Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis

Hao, H. Q., Zhang, J. F., He, Q. Q., & Wang, Z. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.10.009 · Cited by 118 · see citing works

Low‐intensity pulsed ultrasound (LIPUS) increases the articular cartilage type II collagen in a rat osteoarthritis model

Naito, K., Watari, T., Muta, T., Furuhata, A., Iwase, H., Igarashi, M., Kurosawa, H., Nagaoka, I., & Kaneko, K. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20995 · Cited by 118 · see citing works

Role of subchondral bone in osteoarthritis development: A comparative study of two strains of guinea pigs with and without spontaneously occurring osteoarthritis

Muraoka, T., Hagino, H., Okano, T., Enokida, M., & Teshima, R. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22921 · Cited by 117 · see citing works

Circulating glioma biomarkers

Kros, J. M., Mustafa, D. A. M., Dekker, L. J. M., Smitt, P. A. E. S., Luider, T. M., & Zheng, P. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou207 · Cited by 116 · see citing works

Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis

Garnero, P., Conrozier, T., Christgau, S., Mathieu, P., Delmas, P. D., & Vignon, E. P. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.10.939 · Cited by 116 · see citing works

Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse

Ward, B. D., Furman, B. D., Huebner, J. L., Kraus, V. B., Guilak, F., & Olson, S. A. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23288 · Cited by 113 · see citing works

Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH Cohort

Mazières, B., Garnero, P., Guéguen, A., Abbal, M., Berdah, L., Lequesne, M. G., Nguyen, M., Salles, J., Vignon, E. P., & Dougados, M. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.037275 · Cited by 113 · see citing works

In Vitro, Ex Vivo , and In Vivo Methodological Approaches for Studying Therapeutic Targets of Osteoporosis and Degenerative Joint Diseases: How Biomarkers Can Assist?

Schaller, S., Henriksen, K., Høegh-Andersen, P., Søndergaard, B. C., Sumer, E. U., Tankó, L. B., Qvist, P., & Karsdal, M. A. (2005) · Assay and Drug Development Technologies · doi:10.1089/adt.2005.3.553 · Cited by 112 · see citing works

Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: A new potential treatment of osteoarthritis

Bagger, Y. Z., Tankó, L. B., Alexandersen, P., Karsdal, M. A., Olson, M., Mindeholm, L., Azria, M., & Christiansen, C. (2005) · Bone · doi:10.1016/j.bone.2005.04.032 · Cited by 109 · see citing works

The assessment of early osteoarthritis

Pollard, T. C. B., Gwilym, S. E., & Carr, A. J. (2008) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.90b4.20284 · Cited by 109 · see citing works

YKL-40 Protein Expression in the Early Developing Human Musculoskeletal System

Johansen, J. S., Høyer, P. E., Larsen, L. A., Price, P. A., & Møllgård, K. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.7a7245.2007 · Cited by 98 · see citing works

A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years

Erhart‐Hledik, J. C., Favre, J., Asay, J. L., Smith, R. L., Giori, N. J., Mündermann, A., & Andriacchi, T. P. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.07.018 · Cited by 96 · see citing works

Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis

Poole, A. R. (2003) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(03)00056-5 · Cited by 94 · see citing works

Can YKL-40 be a new inflammatory biomarker in cardiovascular disease?

Kastrup, J. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.04.007 · Cited by 91 · see citing works

Type II collagen markers in osteoarthritis: what do they indicate?

Henrotin, Y., Addison, S., Kraus, V., & Deberg, M. (2007) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32829fb3b5 · Cited by 108 · see citing works

Changes in peripheral blood immune cell composition in osteoarthritis

Ponchel, F., Burska, A. N., Hensor, E. M. A., Raja, R., Campbell, M., Emery, P., & Conaghan, P. G. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.06.018 · Cited by 88 · see citing works

Association Between Experimental Pain Biomarkers and Serologic Markers in Patients With Different Degrees of Painful Knee Osteoarthritis

Arendt‐Nielsen, L., Eskehave, T. N., Egsgaard, L. L., Petersen, K. K., Graven‐Nielsen, T., Hoeck, H. C., Simonsen, O. H., Siebuhr, A. S., Karsdal, M. A., & Bay‐Jensen, A. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38856 · Cited by 89 · see citing works

Osteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective study

Bruyère, O., Collette, J., Kothari, M., Zaïm, S., White, D. L., Genant, H. K., PETERFY, C. G., Burlet, N., Ethgen, D. J., Montague, T., et al. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.045914 · Cited by 89 · see citing works

Review: Collagen markers in early arthritic diseases.

Elsaid, K., & Chichester, C. (2006) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/j.cca.2005.09.020 · Cited by 92 · see citing works

Clusters within a wide spectrum of biochemical markers for osteoarthritis: data from CHECK, a large cohort of individuals with very early symptomatic osteoarthritis

van Spil, W. E., Jansen, N. W. D., Bijlsma, J. W. J., Reijman, M., DeGroot, J., Welsing, P. M. J., & Lafeber, F. P. J. G. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.04.004 · Cited by 86 · see citing works

Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model

Naito, K., Watari, T., Furuhata, A., Yomogida, S., Sakamoto, K., Kurosawa, H., Kaneko, K., & Nagaoka, I. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.02.015 · Cited by 85 · see citing works

First Qualification Study of Serum Biomarkers as Indicators of Total Body Burden of Osteoarthritis

Kraus, V. B., Kepler, T. B., Stäbler, T., Renner, J. B., & Jordan, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009739 · Cited by 85 · see citing works

Longitudinal changes of serum COMP and urinary CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in women

Sowers, M., Karvonen-Gutierrez, C. A., Yosef, M., Jannausch, M. L., Jiang, Y., Garnero, P., & Jacobson, J. A. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.06.001 · Cited by 85 · see citing works

Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: From in vitro to in vivo

Nemirovskiy, O. V., Dufield, D. R., Sunyer, T., Aggarwal, P., Welsch, D., & Mathews, W. R. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.10.034 · Cited by 85 · see citing works

Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes.

Afif, H., Li, X., Pelletier, J., Pelletier, J.-P., & Fahmi, H. (2004) · Arthritis Research · doi:10.1186/ar1439 · Cited by 84 · see citing works

Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis.

Bruyère, O., Collette, J., Ethgen, O., Rovati, L. C., Giacovelli, G., Henrotin, Y. E., Seidel, L., & Reginster, J. L. (2003) · PubMed · Cited by 83 · see citing works

The effect of mud pack therapy on serum YKL-40 and hsCRP levels in patients with knee osteoarthritis

Gungen, G. O., Ardıç, F., Fιndıkoğlu, G., & Rota, S. (2011) · Rheumatology International · doi:10.1007/s00296-010-1727-4 · Cited by 83 · see citing works

Cell biology of osteoarthritis: The chondrocyte’s response to injury

Fukui, N., Purple, C. R., & Sandell, L. J. (2001) · Current Rheumatology Reports · doi:10.1007/s11926-001-0064-8 · Cited by 81 · see citing works

Association between spine disc degeneration and type II collagen degradation in postmenopausal women: The OFELY study

Garnero, P., Sornay‐Rendu, E., ARLOT, M. E., Christiansen, C., & Delmas, P. D. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20493 · Cited by 79 · see citing works

Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage

Bay‐Jensen, A., Andersen, T. L., Tabassi, N. C.-B., Kristensen, P. W., Kjærsgaard‐Andersen, P., Sandell, L. J., Garnero, P., & Delaissé, J. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.09.006 · Cited by 78 · see citing works

Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis

van Spil, W. E., Drossaers-Bakker, K. W., & Lafeber, F. P. J. G. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-201177 · Cited by 78 · see citing works

Nanotechnological Strategies for Osteoarthritis Diagnosis, Monitoring, Clinical Management, and Regenerative Medicine: Recent Advances and Future Opportunities

Mohammadinejad, R., Ashrafizadeh, M., Pardakhty, A., Uzielienè, I., Denkovskij, J., Bernotienė, E., Janssen, L., Lorite, G. S., Saarakkala, S. S., & Mobasheri, A. (2020) · Current Rheumatology Reports · doi:10.1007/s11926-020-0884-z · Cited by 78 · see citing works

Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training

Petersen, S. G., Saxne, T., Heinegård, D. K., Hansen, M., Holm, L., Koskinen, S., Stordal, C., Christensen, H., Aagaard, P., & Kjær, M. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.07.004 · Cited by 77 · see citing works

The role of bone metabolism in osteoarthritis

Hunter, D. J., & Spector, T. D. (2003) · Current Rheumatology Reports · doi:10.1007/s11926-003-0078-5 · Cited by 75 · see citing works

Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men

Jordan, K. M., Syddall, H. E., Garnero, P., Gineyts, É., Dennison, E. M., Sayer, A. A., Delmas, P. D., Cooper, C. C., & Arden, N. K. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.042895 · Cited by 75 · see citing works

Effect of bisphosphonates on cartilage turnover assessed with a newly developed assay for collagen type II degradation products

Lehmann, H.-J., Mouritzen, U., Christgau, S., Cloos, P. A., & Christiansen, C. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.6.530 · Cited by 75 · see citing works

Republished: Value of biomarkers in osteoarthritis: current status and perspectives

Lotz, M., Pelletier, J., Christiansen, C., Brandi, M. L., Bruyère, O., Chapurlat, R. D., Collette, J., Cooper, C. C., Giacovelli, G., Kanis, J. А., et al. (2014) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2013-203726rep · Cited by 74 · see citing works

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

Connor, J. R., LePage, C., Swift, B. A., Yamashita, D. S., Bendele, A. M., Maul, D., & Kumar, S. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.03.015 · Cited by 73 · see citing works

The utility of measuring C-terminal telopeptides of collagen type II (CTX-II) in serum and synovial fluid samples for estimation of articular cartilage status in experimental models of destructive joint diseases

Oestergaard, S., Chouinard, L., Doyle, N., Karsdal, M. A., Smith, S. Y., Qvist, P., & Tankó, L. B. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.01.004 · Cited by 74 · see citing works

Increased Urinary Concentration of Collagen Type II C-Telopeptide Fragments in Patients with Osteoarthritis

Jung, M., Christgau, S., Lukoschek, M., Henriksen, D. B., & Richter, W. (2004) · Pathobiology · doi:10.1159/000074419 · Cited by 71 · see citing works

Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index

Kerkhof, H. J. M., Bierma‐Zeinstra, S., Castano-Betancourt, M. C., de Maat, M. P. M., Albert Hofman, D., Pols, H. A. P., Rivadeneira, F., Witteman, J. C. M., Uitterlinden, A. G., & van Meurs, J. B. J. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.125260 · Cited by 67 · see citing works

YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints

Väänänen, T., Koskinen, A., Paukkeri, E.-L., Hämäläinen, M., Moilanen, T., Moilanen, E., & Vuolteenaho, K. (2014) · Mediators of Inflammation · doi:10.1155/2014/215140 · Cited by 63 · see citing works

Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis

Gineyts, É., Mo, J. A., Ko, A., Henriksen, D. B., Curtis, S. P., Gertz, B. J., Garnero, P., & Delmas, P. D. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.007302 · Cited by 65 · see citing works

Aggrecan and Cartilage Oligomeric Matrix Protein in Serum and Synovial Fluid of Patients with Knee Osteoarthritis

El-Arman, M. M., El-Fayoumi, G., El-Shal, E., El-Boghdady, I., & El-Ghaweet, A. (2010) · HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery · doi:10.1007/s11420-010-9157-0 · Cited by 58 · see citing works

Effects of Whole Body Vibration Exercise associated with Quadriceps Resistance Exercise on functioning and quality of life in patients with knee osteoarthritis: a randomized controlled trial

Wang, P., Yang, L., Liu, C., Wei, X., Yang, X., Zhou, Y., Jiang, H., Lei, Z., Reinhardt, J. D., & He, C. (2015) · Clinical Rehabilitation · doi:10.1177/0269215515607970 · Cited by 58 · see citing works

Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes

Oren, T. W., Boțolin, S., Williams, A., Bucknell, A. L., & King, K. B. (2011) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2010.09.0186 · Cited by 58 · see citing works

Sport-related differences in biomarkers of bone resorption and cartilage degradation in endurance athletes

O’Kane, J. W., Hutchinson, E., Atley, L. M., & Eyre, D. R. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.08.003 · Cited by 58 · see citing works

Significance of the serum CTX-II level in an osteoarthritis animal model: a 5-month longitudinal study

Duclos, M.-È., Roualdes, O., Cararo, R. D. R., Rousseau, J., Roger, T., & Hartmann, D. J. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.07.007 · Cited by 57 · see citing works

One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression

Deberg, M. A., Labasse, A., Collette, J., Seidel, L., Reginster, J.-Y., & Henrotin, Y. E. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.06.014 · Cited by 57 · see citing works

Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative

Kanthawang, T., Bodden, J. H., Joseph, G. B., Lane, N. E., Nevitt, M. C., McCulloch, C. E., & Link, T. M. (2020) · Skeletal Radiology · doi:10.1007/s00256-020-03550-5 · Cited by 56 · see citing works

Calcitonin is involved in cartilage homeostasis: Is calcitonin a treatment for OA?

Karsdal, M. A., Tankó, L. B., Riis, B. J., Søndergaard, B. C., Henriksen, K., Altman, R. D., Qvist, P., & Christiansen, C. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.03.014 · Cited by 56 · see citing works

Associations between biomarkers of bone and cartilage turnover, gender, pain categories and radiographic severity in knee osteoarthritis

Bihlet, A. R., Byrjalsen, I., Bay‐Jensen, A., Andersen, J. R., Christiansen, C., Riis, B. J., & Karsdal, M. A. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1987-7 · Cited by 56 · see citing works

Association of higher levels of serum cartilage oligomeric matrix protein and N‐telopeptide crosslinks with the development of radiographic hip osteoarthritis in elderly women

Kelman, A., Lui, L.-Y., Yao, W., Krumme, A. A., Nevitt, M. C., & Lane, N. E. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21527 · Cited by 54 · see citing works

Serum keratan sulfate is a promising marker of early articular cartilage breakdown

Wakitani, S., Nawata, M., Kawaguchi, A., Okabe, T., Takaoka, K., Tsuchiya, T., Nakaoka, R., Masuda, H., & Miyazaki, K. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem220 · Cited by 54 · see citing works

Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis

McDougall, J. J., Schuelert, N., & Bowyer, J. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.07.014 · Cited by 53 · see citing works

Relationship of serum markers of cartilage metabolism to imaging and clinical outcome measures of knee joint structure

Berry, P. A., Maciewicz, R. A., Wluka, A. E., Downey-Jones, M. D., Forbes, A. B., Hellawell, C. J., & Cicuttini, F. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.124420 · Cited by 53 · see citing works

Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts

Kerkhof, J., Uitterlinden, A. G., Valdes, A. M., Hart, D. J., Rivadeneira, F., Jhamai, M. M., Albert Hofman, D., Pols, H. A. P., Bierma‐Zeinstra, S., Spector, T. D., et al. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.02.007 · Cited by 52 · see citing works

Serum hyaluronic acid as a potential marker with a predictive value for further radiographic progression of hand osteoarthritis

Filková, M., Šenolt, L., BRAUN, M. A., Hulejová, H., Pavelková, A., Šléglová, O., Kupka, K., Gatterová, J., & Pavelká, K. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.06.002 · Cited by 51 · see citing works

Can biochemical markers serve as surrogates for imaging in knee osteoarthritis?

Davis, C. R., Karl, J., Granell, R., Kirwan, J., Fasham, J., Johansen, J. S., Garnero, P., & Sharif, M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23129 · Cited by 50 · see citing works

Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men

Jordan, K. M., Syddall, H. E., Garnero, P., Gineyts, É., Dennison, E. M., Sayer, A. A., Delmas, P. D., Cooper, C. C., & Arden, N. K. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.042895 · Cited by 75 · see citing works

Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis

Gineyts, É., Mo, J. A., Ko, A., Henriksen, D. B., Curtis, S. P., Gertz, B. J., Garnero, P., & Delmas, P. D. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.007302 · Cited by 65 · see citing works

A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis--association with disease progression

Sharif, M., Kirwan, J., Charni, N., Sandell, L. J., Whittles, C. E., & Garnero, P. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kel409 · Cited by 115 · see citing works

One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression

Deberg, M. A., Labasse, A., Collette, J., Seidel, L., Reginster, J.-Y., & Henrotin, Y. E. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.06.014 · Cited by 57 · see citing works

Increased urinary type II collagen C-telopeptide levels in Tunisian patients with knee osteoarthritis.

Kalai, E., Bahlous, A. H. S., Charni, N., Bouzid, K., Sahli, H., Chelly, M., Meddeb, M., Zouari, B., Abdelmoula, J., & Sellami, S. (2012) · PubMed · Cited by 15 · see citing works