The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Synovial tissue macrophage populations and articular damage in rheumatoid arthritis
Abstract
Objective. To examine the relative contribution of individual synovial cell populations to polyarticular destruction in rheumatoid arthritis (RA). Methods. Serial measurements of disease activity and articular destruction, obtained prospectively in 28 RA patients followed up for a mean of 5.8 years, were correlated with synovial cell populations quantified using immunohistochemical techniques. Results. The mean radiologic score worsened (from 37 to 86; P = 0.0001) despite significant improvement in disease activity. Synovial lining layer cell depth and sublining layer macrophage, but not lymphocyte, cell counts correlated significantly with radiologic course. Detailed analysis of 11 patients demonstrated reduced synovial lining expression of CD14 compared with CD68 (P = 0.003), whereas sublining expression of CD14 and CD68 was equivalent. Conclusion. Synovial macrophage numbers correlated with articular destruction in RA. In addition, the study results provided further evidence that lining layer macrophages may represent a distinct subpopulation that is of importance in this process. These findings have implications for the development of new therapies for RA.
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Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlane, J. D., Bijl, J. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90628-9 · Cited by 1,682
Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen.
Backé, E., Schwarting, R., Gerdes, J., Ernst, M., & Stein, H. (1991) · Journal of Clinical Pathology · doi:10.1136/jcp.44.11.936 · Cited by 92
Cited by
PI3Kδ and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?
Rommel, C., Camps, M., & Ji, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2036 · Cited by 398
Progression of radiologic damage in patients with rheumatoid arthritis in clinical remission
Molenaar, E. T. H., Voskuyl, A. E., Dinant, H. J., Bezemer, P. D., Boers, M., & Dijkmans, B. A. C. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11481 · Cited by 384
Kirkham, B. W., Lassere, M. N., Edmonds, J. P., Juhasz, K. M., Bird, P. A., Lee, C. S., Shnier, R., & Portek, I. J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21749 · Cited by 336
Cells of the synovium in rheumatoid arthritis. Macrophages
Kinne, R. W., Stuhlmüller, B., & Burmester, G.-R. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2333 · Cited by 300
Park, S., Chun, K., Kim, J., Suk, K., Jung, Y., & Lee, W. (2010) · Phytotherapy Research · doi:10.1002/ptr.3140 · Cited by 90
Metadata
- Authors
- Mulherin, D., Fitzgerald, O., & Bresnihan, B.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1996-01
- Volume
- 39
- Issue
- 1
- Pages
- 115-124
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2000539788
- Cited by
- 515
- References
- 2
- FWCI
- 13.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mulherin, D., Fitzgerald, O., & Bresnihan, B. (1996). Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780390116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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