Ber-MAC3: new monoclonal antibody that defines human monocyte/macrophage differentiation antigen.
Open accessAbstract
A new monoclonal antibody Ber-MAC3 is reported. It recognises a formol sensitive epitope of a not yet clustered monocyte/macrophage specific 140 kilodalton glycoprotein that is expressed on the cell surface and in the cytoplasm. In 30 cases of acute and chronic leukaemia, Ber-MAC3 staining was restricted to 15 myeloid leukaemias of M4 and M5 types. The tumour cells of two cases of true histiocytic malignancies were Ber-MAC3 positive, whereas those of all 280 malignancies of lymphocytic origin were negative. The latter included 52 cases of Hodgkin's disease and 41 cases of Ki-1 positive anaplastic large cell lymphomas which had previously been classified as true histiocytic lymphomas. Ber-MAC3 therefore seems to be of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and seems to be suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin.
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Mac3 antigen is a marker specific to tissue activated macrophages.
“Mac3 antigen, a marker specific to tissue activated macrophages.33”
From Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the <i>in vitro</i> activation of macrophages and <i>in vivo</i> host response to poly(ethylene glycol)‐based hydrogels (2012) · cites this paper as [33]
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- Authors
- Backé, E., Schwarting, R., Gerdes, J., Ernst, M., & Stein, H.
- ORCID
- Ernst, M
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 1991-11
- Volume
- 44
- Issue
- 11
- Pages
- 936-945
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- PMC
- PMC496636
- OpenAlex
- W2171296853
- Cited by
- 92
- References
- 58
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 6 · 2012: 6
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- monoclonal antibodies, monocytic leukemia, histiocytic lymphoma, Hodgkin's disease, anaplastic large cell lymphoma, myeloid leukemia, immunohistochemistry, cell surface antigens
- MeSH terms
- Antibodies, Monoclonal, Epitopes, Antigens, Differentiation, Humans, Macrophages, Membrane Glycoproteins, Molecular Weight, Monocytes, Histiocytic Disorders, Malignant
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