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Cited by 377

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis

Jones, Elena A., English, Anne, Henshaw, Karen, Kinsey, Sally E., Markham, Alex F., Emery, Paul, McGonagle, Dennis·2004·Arthritis & Rheumatism
DOI 10.1002/art.20203
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Abstract

Objective: To evaluate synovial fluid (SF) for the presence of mesenchymal progenitor cells (MPCs), to compare SF MPCs with bone marrow (BM) MPCs, and to enumerate these cells in both inflammatory arthritis and osteoarthritis (OA). Methods: SF from 100 patients with arthritis (53 rheumatoid arthritis [RA], 20 OA, and 27 other arthropathies) was evaluated. To establish multipotentiality, polyclonal and single cell–derived cultures of SF fibroblasts were examined by standard and quantitative differentiation assays. Their phenotype before and after expansion was determined by multiparameter flow cytometry. A colony‐forming unit–fibroblast assay was used for SF MPC enumeration. Results: Regardless of the nature of the arthritis, both polyclonal and single cell–derived cultures of SF fibroblasts possessed trilineage mesenchymal differentiation potentials. The number of MPCs in a milliliter of SF was higher in OA (median 37) than in RA (median 2) (P < 0.00001). No significant differences in MPC numbers were found between early and established RA (median 3 and 2 cells/ml, respectively). Culture‐expanded SF and BM MPCs had the same phenotype (negative for CD45 and positive for D7‐FIB, CD13, CD105, CD55, and CD10). Rare, uncultured SF fibroblasts were CD45 low and expressed low‐affinity nerve growth factor receptor, similar to in vivo BM MPCs. Conclusion: Our findings prove the presence of rare tripotential MPCs, at the single‐cell level, in the SF of patients with arthritis. SF MPCs are clonogenic and multipotential fibroblasts that, despite the pathologic environment within a diseased joint, have a phenotype similar to that of uncultured BM MPCs. The higher prevalence of MPCs in OA SF suggests their likely origin from disrupted joint structures. These findings could determine the role of MPCs in the pathogenesis of inflammatory arthritis, together with their role in attempted joint regeneration in degenerative arthritis, which has yet to be established.

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Metadata

Authors
Jones, E. A., English, A., Henshaw, K., Kinsey, S. E., Markham, A. F., Emery, P., & McGonagle, D.
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
2004-03
Volume
50
Issue
3
Pages
817-827
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/art.20203
OpenAlex
W2013313311
Cited by
377
References
38
FWCI
9.67
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis. https://app.cochat.ai/papers/10.1002/art.20203
The paper
Jones, E. A., English, A., Henshaw, K., Kinsey, S. E., Markham, A. F., Emery, P., & McGonagle, D. (2004). Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.20203

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.