The Pathogenesis of Rheumatoid Arthritis

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works

2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative

Aletaha, D., Neogi, T., Silman, A. J., Funovits, J., Felson, D. T., Bingham, C. O., Birnbaum, N. S., Burmester, G. R., Bykerk, V. P., Cohen, M. D., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.138461 · Cited by 4,959 · see citing works

Evolving concepts of rheumatoid arthritis

Firestein, G. S. (2003) · Nature · doi:10.1038/nature01661 · Cited by 3,601 · see citing works

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis

Edwards, J. C. W., Szczepański, L., Szechiński, J., Filipowicz-Sosnowska, A., Emery, P., Close, D. R., Stevens, R. M., & Shaw, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032534 · Cited by 2,623 · see citing works

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

Gregersen, P. K., Silver, J., & WINCHESTER, R. J. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780301102 · Cited by 2,604 · see citing works

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

(2010) · The Lancet · doi:10.1016/s0140-6736(09)61717-7 · Cited by 2,546 · see citing works

Cytokines in the pathogenesis of rheumatoid arthritis

McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,523 · see citing works

Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis

Rantapää‐Dahlqvist, S., Jong, B. A. W. D., Berglin, E. H., Hallmans, G., Wadell, G., Stenlund, H. C., Sundin, U., & VENROOIJ, W. J. V. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,946 · see citing works

A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

Klareskog, L., Stolt, P., Lundberg, K., Källberg, H., Bengtsson, C., Grünewald, J., Rönnelid, J., Harris, H. E., Ulfgren, A., Rantapää‐Dahlqvist, S., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21575 · Cited by 1,516 · see citing works

A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

Begovich, A. B., Carlton, V. E. H., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K., Huang, Q., Smith, A. M., Spoerke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422827 · Cited by 1,501 · see citing works

Interleukin-17 and Type 17 Helper T Cells

Miossec, P., Korn, T., & Kuchroo, V. K. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0707449 · Cited by 1,409 · see citing works

The mortality of rheumatoid arthritis

Wolfe, F., Mitchell, D. M., Sibley, J. T., Fries, J. F., Bloch, D. A., Williams, C. A., Spitz, P. W., Haga, M., Kleinheksel, S. M., & Cathey, M. A. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370408 · Cited by 1,325 · see citing works

EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis

Peters, M. J. L., Symmons, D. P. M., McCarey, D., Dijkmans, B. A. C., Nicola, P., Kvien, T. K., McInnes, I. B., Haentzschel, H., Gonzalez-Gay, M. A., Provan, S., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.113696 · Cited by 1,325 · see citing works

Dickkopf-1 is a master regulator of joint remodeling

Diarra, D., Stolina, M., Polzer, K., Zwerina, J., Ominsky, M. S., Dwyer, D., Korb, A., Smolen, J. S., Hoffmann, M. H., Scheinecker, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1538 · Cited by 1,296 · see citing works

Cardiovascular Morbidity and Mortality in Women Diagnosed With Rheumatoid Arthritis

Solomon, D. H., Karlson, E. W., Rimm, E. B., Cannuscio, C. C., Mandl, L. A., Manson, J. E., Stampfer, M. J., & Curhan, G. C. (2003) · Circulation · doi:10.1161/01.cir.0000054612.26458.b2 · Cited by 1,240 · see citing works

Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study

Choi, H. K., Hernán, M. Á., Seeger, J. D., Robins, J. M., & Wolfe, F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08213-2 · Cited by 1,127 · see citing works

Evidence that cytokines play a role in rheumatoid arthritis

Brennan, F. M., & McInnes, I. B. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36389 · Cited by 1,103 · see citing works

STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

Remmers, E. F., Plenge, R. M., Lee, A. T., Graham, R., Hom, G., Behrens, T. W., de Bakker, P. I. W., Le, J. M., Lee, H., Batliwalla, F., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073003 · Cited by 1,040 · see citing works

Rheumatoid Arthritis

Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81109-5 · Cited by 978 · see citing works

Explaining How “High-Grade” Systemic Inflammation Accelerates Vascular Risk in Rheumatoid Arthritis

Sattar, N. A., McCarey, D. W., Capell, H. A., & McInnes, I. B. (2003) · Circulation · doi:10.1161/01.cir.0000099844.31524.05 · Cited by 932 · see citing works

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

Stańczyk, J., Pedrioli, D. M. L., Brentano, F., Sánchez‐Pernaute, O., Kolling, C., Gay, R. E., Detmar, M. J., Gay, S., & Kyburz, D. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23386 · Cited by 905 · see citing works

How to diagnose rheumatoid arthritis early: A prediction model for persistent (erosive) arthritis

VISSER, H. K. A., le Cessie, S., Vos, K., Breedveld, F. C., & Hazes, J. M. W. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10117 · Cited by 730 · see citing works

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

Lefèvre, S., Knedla, A., Tennie, C., Kampmann, A., Wunrau, C., Dinser, R., Korb, A., Schnaeker, E., Tarner, I. H., Robbins, P. D., et al. (2009) · Nature Medicine · doi:10.1038/nm.2050 · Cited by 716 · see citing works

Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α‐enolase: Implications for autoimmunity in rheumatoid arthritis

Wegner, N., Wait, R., Sroka, A., Eick, S., Nguyen, K.-A. T., Lundberg, K., Kinloch, A., Culshaw, S., Potempa, J., & Venables, P. J. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27552 · Cited by 690 · see citing works

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

Kurowska‐Stolarska, M., Alivernini, S., Ballantine, L. E., Asquith, D. L., Millar, N. L., Gilchrist, D. S., Reilly, J. H., Ierna, M. X., Fraser, A. R., Stolarski, B., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019536108 · Cited by 639 · see citing works

The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth

Rhee, D. K., Marcelino, J. R., Baker, M., Gong, Y., Smits, P. J., Lefebvre, V., Jay, G. D., Stewart, M. C., Wang, H., Warman, M. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522263 · Cited by 630 · see citing works

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

Plenge, R. M., Cotsapas, C. J., Davies, L. R. L., Price, A. L., de Bakker, P. I. W., Maller, J., Pe’er, I., Burtt, N. P., Blumenstiel, B. S., DeFelice, M., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.27 · Cited by 550 · see citing works

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double‐blind, placebo‐controlled phase IIa trial of three dosage levels of CP‐690,550 versus placebo

Kremer, J. M., Bloom, B. J., Breedveld, F. C., Coombs, J. H., Fletcher, M. P., Gruben, D. C., Krishnaswami, S., Burgos‐Vargas, R., Wilkinson, B. E., Zerbini, C. A. F., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24567 · Cited by 547 · see citing works

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

Humby, F., Bombardieri, M., Manzo, A., Kelly, S., Blades, M. C., Kirkham, B., Spencer, J., & Pitzalis, C. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.0060001 · Cited by 537 · see citing works

Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis.

Jacobsson, L., Turesson, C., Gülfe, A., Kapetanovic, M. C., Petersson, I. F., Saxne, T., & Geborek, P. (2005) · PubMed · Cited by 533 · see citing works

Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.

Gravallese, E. M., Harada, Y., Wang, J. T., Gorn, A. H., Thornhill, T. S., & Goldring, S. R. (1998) · Europe PMC (PubMed Central) · Cited by 512 · see citing works

Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β

Nadkarni, S., Mauri, C., & Ehrenstein, M. R. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061531 · Cited by 506 · see citing works

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

Raza, K., Francesco Falciani, B., Curnow, J., Ross, E. J., Lee, C.-Y., Akbar, A. N., Lord, J. M., Gordon, C., Buckley, C. D., & Salmon, M. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1733 · Cited by 506 · see citing works

The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth

Rhee, D. K., Marcelino, J. R., Baker, M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22263 · Cited by 501 · see citing works

Factors predicting response to treatment in rheumatoid arthritis: The importance of disease duration

Anderson, J. J., Wells, G. A., Verhoeven, A. C., & Felson, D. T. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 500 · see citing works

A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis

Smitten, A. L., Simon, T. A., Hochberg, M. C., & Suissa, S. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2404 · Cited by 476 · see citing works

Immunity to Citrullinated Proteins in Rheumatoid Arthritis

Klareskog, L., Rönnelid, J., Lundberg, K., Padyukov, L., & Alfredsson, L. S. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090244 · Cited by 463 · see citing works

Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines

Chabaud, M., Fossiez, F., Taupin, J., & Miossec, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.409 · Cited by 457 · see citing works

Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis

Haringman, J. J., Gerlag, D. M., Zwinderman, A. H., Smeets, T. J. M., Kraan, M. C., Baeten, D., McInnes, I. B., Bresnihan, B., & Tak, P. P. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.029751 · Cited by 457 · see citing works

Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis

Källberg, H., Padyukov, L., Plenge, R. M., Rönnelid, J., Gregersen, P. K., Mil, A. H. M. V. D. H., Toes, R. E. M., Huizinga, T. W. J., Klareskog, L., & Alfredsson, L. S. (2007) · The American Journal of Human Genetics · doi:10.1086/516736 · Cited by 455 · see citing works

LY2439821, a humanized anti–interleukin‐17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double‐blind, placebo‐controlled, proof‐of‐concept study

Genovese, M. C., den Bosch, F. E. V., Roberson, S., Bojin, S., Biagini, I. M., Ryan, P. F. J., & Sloan‐Lancaster, J. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27334 · Cited by 451 · see citing works

Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis.

Schröder, A. E., Greiner, A., Seyfert, C., & Berek, C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.221 · Cited by 433 · see citing works

Cadherin-11 in Synovial Lining Formation and Pathology in Arthritis

Lee, D. M., Kiener, H. P., Agarwal, S. K., Noss, E. H., Watts, G. F. M., Chisaka, O., Takeichi, M., & Brenner, M. B. (2007) · Science · doi:10.1126/science.1137306 · Cited by 415 · see citing works

Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis. Results from a primary care‐based incident case‐control study in Norfolk, England

Symmons, D. P. M., Bankhead, C. R., Harrison, B., Brennan, P., Silman, A. J., Barrett, E. M., & Scott, D. G. I. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780401106 · Cited by 402 · see citing works

An Oral Spleen Tyrosine Kinase (Syk) Inhibitor for Rheumatoid Arthritis

Weinblatt, M. E., Kavanaugh, A., Genovese, M. C., Musser, T. K., Grossbard, E. B., & Magilavy, D. B. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000500 · Cited by 382 · see citing works

Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis

Jones, E., English, A., Henshaw, K., Kinsey, S. E., MARKHAM, A. F., Emery, P., & McGonagle, D. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20203 · Cited by 376 · see citing works

MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA)

Hetland, M. L., Ejbjerg, B., Hørslev‐Petersen, K., Jacobsen, S., Vestergaard, A. R., Jurik, A. G., Stengaard‐Pedersen, K., Junker, P., Lottenburger, T., Hansen, I., et al. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.088245 · Cited by 370 · see citing works

Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium

Hueber, A. J., Asquith, D. L., Miller, A. M., Reilly, J. S., Kerr, S. C., Leipe, J., Melendez, A. J., & McInnes, I. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903566 · Cited by 358 · see citing works

Blockade of TNF-α rapidly inhibits pain responses in the central nervous system

Heß, A., Axmann, R., Rech, J., Finzel, S., Heindl, C., Kreitz, S., Sergeeva, M., Saake, M., Garcia, M., Kollias, G. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011774108 · Cited by 357 · see citing works

Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations

Rycke, L. D., Peene, I., Hoffman, I. E. A., Kruithof, E., Union, A., Meheus, L., Lebeer, K., Wyns, B., Vincent, C., Mielants, H., et al. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.017574 · Cited by 342 · see citing works

Joint Erosions and Patients with Early Rheumatoid Arthritis

van der Heijde, D. M. F. M. (1995) · Lara D. Veeken · doi:10.1093/rheumatology/xxxiv.suppl_2.74 · Cited by 323 · see citing works

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

van der Woude, D., Rantapää‐Dahlqvist, S., Ioan‐Facsinay, A., Onnekink, C., Schwarte, C. M., Verpoort, K. N., Drijfhout, J. W., Huizinga, T. W. J., Toes, R. E. M., & Pruijn, G. J. M. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.124537 · Cited by 318 · see citing works

Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions

Choy, E., & Sattar, N. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.101964 · Cited by 314 · see citing works

Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis

Mahdi, H., Fisher, B. A., Källberg, H., Plant, D., Malmström, V., Rönnelid, J., Charles, P. J., Ding, B., Alfredsson, L. S., Padyukov, L., et al. (2009) · Nature Genetics · doi:10.1038/ng.480 · Cited by 309 · see citing works

Role for TNF in atherosclerosis? Lessons from autoimmune disease

McKellar, G., McCarey, D. W., Sattar, N. A., & McInnes, I. B. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.57 · Cited by 295 · see citing works

Expression and Regulation of Toll-Like Receptor 2 in Rheumatoid Arthritis Synovium

Seibl, R., Birchler, T., Loeliger, S., Hossle, J. P., Gay, R. E., Saurenmann, T., Michel, B. A., Seger, R. A., Gay, S., & Lauener, R. P. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63918-1 · Cited by 286 · see citing works

A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis

Kurreeman, F. A. S., Padyukov, L., Marques, R. B., Schrodi, S. J., Seddighzadeh, M., Stoeken‐Rijsbergen, G., Mil, A. H. M. V. D. H., Allaart, C. F., Verduyn, W., Houwing‐Duistermaat, J. J., et al. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040278 · Cited by 276 · see citing works

Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathyPreprint

Amano, T., Yamasaki, S., Yagishita, N., Tsuchimochi, K., Shin, H., Kawahara, K., Aratani, S., Fujita, H., Zhang, L., Ikeda, R., et al. (2003) · Genes & Development · doi:10.1101/gad.1096603 · Cited by 270 · see citing works

BLyS and APRIL in rheumatoid arthritis

Seyler, T. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25265 · Cited by 266 · see citing works

Essential role of microRNA‐155 in the pathogenesis of autoimmune arthritis in mice

Blüml, S., Bonelli, M. M., Niederreiter, B., Puchner, A., Mayr, G., Hayer, S., Koenders, M. I., van den Berg, W. B., Smolen, J. S., & Redlich, K. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30281 · Cited by 253 · see citing works

Neutrophils in rheumatoid arthritis: More than simple final effectors

Cascão, R., Rosário, H. S., Souto‐Carneiro, M., & Fonseca, J. E. (2010) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.12.013 · Cited by 245 · see citing works

Therapeutic targeting of Janus kinases

Pesu, M., Laurence, A. D. J., Kishore, N. N., Zwillich, S. H., Chan, G. L., & O’Shea, J. J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00644.x · Cited by 232 · see citing works

High-Sensitivity C-Reactive Protein and Risk of Nontraumatic Fractures in the Bruneck Study

Schett, G. A. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.22.2495 · Cited by 225 · see citing works

Fibroblast-Like Synoviocytes of Mesenchymal Origin Express Functional B Cell-Activating Factor of the TNF Family in Response to Proinflammatory Cytokines

Ohata, J., Zvaifler, N. J., Nishio, M., Boyle, D. L., Kalled, S. L., Carson, D. A., & Kipps, T. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.864 · Cited by 212 · see citing works

Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs.

Schett, G. A., Redlich, K., Xu, Q., Bizan, P., Gröger, M., Tohidast-Akrad, M., Kiener, H. P., Smolen, J. S., & Steiner, G. E. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2465 · Cited by 207 · see citing works

Transcriptional profiles discriminate bone marrow-derived and synovium-derived mesenchymal stem cells

Djouad, F., Bony, C., Häupl, T., Uzé, G., Lahlou, N., Louis‐Plence, P., Apparailly, F., Canovas, F., Reme, T. X., Sany, J., et al. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1827 · Cited by 204 · see citing works

Lymphoma subtypes in patients with rheumatoid arthritis: Increased proportion of diffuse large B cell lymphoma

Baecklund, E., Sundström, C., Ekbom, A., Catrina, A. I., Biberfeld, P., Feltelius, N., & Klareskog, L. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11144 · Cited by 181 · see citing works

Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis

Kamphuis, S., Kuis, W., de Jager, W., Teklenburg, G., Massa, M., Gordon, G., Boerhof, M., Rijkers, G. T., Uiterwaal, C. S. P. M., Otten, H. G., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66827-4 · Cited by 180 · see citing works

Increased levels of C‐reactive protein in serum from blood donors before the onset of rheumatoid arthritis

Nielen, M. M. J., van Schaardenburg, D., Reesink, H. W., Twisk, J. W. R., van de Stadt, R. J., van der Horst-Bruinsma, I. E., Gast, T. D., Habibuw, M. R., Vandenbroucke, J. P., & Dijkmans, B. A. C. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20431 · Cited by 176 · see citing works

G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis

Cornish, A. L., Campbell, I., McKenzie, B., Chatfield, S., & Wicks, I. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.178 · Cited by 172 · see citing works

Rheumatoid fibroblast‐like synoviocytes overexpress the chemokine stromal cell–derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue

Bradfield, P. F., Amft, N., Vernon-Wilson, E. F., Exley, A., Parsonage, G. N., Rainger, G. E., Nash, G. B., Thomas, A. M. C., Simmons, D. L., Salmon, M., et al. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11219 · Cited by 170 · see citing works

Rheumatoid Arthritis Synovium Contains Two Subsets of CD83−DC-LAMP− Dendritic Cells with Distinct Cytokine Profiles

Lebre, M. C., Jongbloed, S. L., Tas, S. W., Smeets, T. J. M., McInnes, I. B., & Tak, P. P. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070703 · Cited by 166 · see citing works

Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis

Güler-Yüksel, M., Allaart, C. F., Goekoop-Ruiterman, Y. P. M., Vries-Bouwstra, J. K. D., van Groenendael, J. H. L. M., Mallee, C., de Bois, M. H. W., Breedveld, F. C., Dijkmans, B. A. C., & Lems, W. F. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.086348 · Cited by 164 · see citing works

Synovial mast cells: role in acute and chronic arthritis

Nigrovic, P. A., & Lee, D. M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00506.x · Cited by 156 · see citing works

Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006

Holmqvist, M. E., Wedrén, S., Jacobsson, L., Klareskog, L., Nyberg, F., Rantapää‐Dahlqvist, S., Alfredsson, L. S., & Askling, J. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02260.x · Cited by 140 · see citing works

Interaction between Synovial Inflammatory Tissue and Bone Marrow in Rheumatoid Arthritis

Jimenez‐Boj, E., Redlich, K., Türk, B., Hanslik‐Schnabel, B., Wanivenhaus, A. H., Chott, A., Smolen, J. S., & Schett, G. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2579 · Cited by 139 · see citing works

Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene.

Aupperle, K. R., Boyle, D. L., Hendrix, M. J. C., Seftor, E. A., Zvaifler, N. J., Barbosa, M. S., & Firestein, G. S. (1998) · Europe PMC (PubMed Central) · Cited by 127 · see citing works

Vascular comorbidity in rheumatoid arthritis: potential mechanisms and solutions

Sattar, N. A., & McInnes, I. B. (2005) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000158150.57154.f9 · Cited by 126 · see citing works

Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target

Capellino, S., Cosentino, M., Wolff, C., Schmidt, M., Grifka, J. K., & Straub, R. H. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.119701 · Cited by 125 · see citing works

How antirheumatic drugs protect joints from damage in rheumatoid arthritis.

Schett, G., Stach, C., Zwerina, J., Voll, R., & Manger, B. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23951 · Cited by 122 · see citing works

Membrane-Type I Matrix Metalloproteinase-Dependent Regulation of Rheumatoid Arthritis Synoviocyte Function

Sabeh, F., Fox, D. A., & Weiss, S. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904068 · Cited by 121 · see citing works

Osteoclasts and Arthritis

Schett, G. A., & Teitelbaum, S. L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090533 · Cited by 120 · see citing works

Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells.

McInnes, I. B., Leung, B. P. L., & Liew, F. Y. (2000) · Arthritis Research · doi:10.1186/ar115 · Cited by 115 · see citing works

Joint Erosions and Patients with Early Rheumatoid Arthritis

van der Heijde, D. M. F. M. (1995) · Lara D. Veeken · doi:10.1093/rheumatology/xxxiv.suppl_4.74 · Cited by 110 · see citing works

Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: Site‐specific versus activation‐dependent survival of T cells and neutrophils

Filer, A. D., Parsonage, G. N., Smith, E., Osborne, C., Thomas, A. M. C., Curnow, J., Rainger, G. E., Raza, K., Nash, G. B., Lord, J. M., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21930 · Cited by 106 · see citing works

Excretion of pyridinium crosslinks correlates with disease activity and appendicular bone loss in early rheumatoid arthritis.

Gough, A., Peel, N. F. A., Eastell, R., Holder, R. L., Lilley, J., & Emery, P. (1994) · Annals of the Rheumatic Diseases · doi:10.1136/ard.53.1.14 · Cited by 106 · see citing works

Tumour necrosis factor blockade increases lymphangiogenesis in murine and human arthritic joints

Polzer, K., Baeten, D., Soleiman, A., Distler, J. H. W., Gerlag, D. M., Tak, P. P., Schett, G. A., & Zwerina, J. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.083394 · Cited by 104 · see citing works

Anti-perinuclear factor compared with the so called “antikeratin” antibodies and antibodies to human epidermis filaggrin, in the diagnosis of arthritides

Vincent, C., Keyser, F. D., Masson-Bessière, C., Sebbag, M., VEYS, E. M., & Serre, G. (1999) · Annals of the Rheumatic Diseases · doi:10.1136/ard.58.1.42 · Cited by 83 · see citing works

Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis

Behrens, F., Himsel, A., Rehart, S., Stanczyk, J., Beutel, B., Zimmermann, S. Y., Koehl, U., Möller, B., Gay, S., Kaltwasser, J., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.068320 · Cited by 80 · see citing works

Microanatomic studies to define predictive factors for the topography of periarticular erosion formation in inflammatory arthritis

McGonagle, D. G., Tan, A. L., Døhn, U. M., Østergaard, M., & Benjamin, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24417 · Cited by 72 · see citing works

Alterations of the synovial T cell repertoire in anti–citrullinated protein antibody–positive rheumatoid arthritis

Cantaert, T., Brouard, S., Thurlings, R. M., Pallier, A., FrancoSalinas, G., Braud, C., Klarenbeek, P. L., de Vries, N., Zhang, Y., Soulillou, J., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24635 · Cited by 71 · see citing works

A function for the QKRAA amino acid motif: mediating binding of DnaJ to DnaK. Implications for the association of rheumatoid arthritis with HLA-DR4.

Auger, I., & Roudier, J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119348 · Cited by 68 · see citing works

Imaging reactive oxygen species dynamics in living cells and tissues

Wu, C.-C. (2009) · Frontiers in Bioscience-Elite · doi:10.2741/e5 · Cited by 63 · see citing works

Immune Dysregulation by the Rheumatoid Arthritis Shared Epitope

de Almeida, D. E., Ling, S., Pi, X., Hartmann-Scruggs, A. M., Pumpens, P., & Holoshitz, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904002 · Cited by 61 · see citing works

Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis

Bajpai, M., Chopra, P., Dastidar, S. G., & Ray, A. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.5.641 · Cited by 59 · see citing works

The role of innate mediators in inflammatory response

Liew, F. Y., & McInnes, I. B. (2002) · Molecular Immunology · doi:10.1016/s0161-5890(02)00014-7 · Cited by 58 · see citing works

Nuclear antigen histone H1 is primarily involved in lupus erythematosus cell formation

Schett, G. A., Steiner, G. E., & Smolen, J. S. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199808)41:8 · Cited by 44 · see citing works

Even though T-cell-directed trials have been of limited success, is there reason for optimism?

Panayi, G. S. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0094 · Cited by 27 · see citing works

Disease-associated human histocompatibility leukocyte antigen determinants in patients with seropositive rheumatoid arthritis. Functional role in antigen-specific and allogeneic T cell recognition.

Weyand, C. M., & Goronzy, J. J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114535 · Cited by 25 · see citing works

Untitled work

Komuro (2001) · doi:10.1002/1529-0131(200112)44:12

NF-κB signaling in inflammation

Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791 · see citing works

Rheumatoid arthritis

Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30173-8 · Cited by 5,026 · see citing works

Rheumatoid arthritis

Smolen, J. S., Aletaha, D., Barton, A. C., Burmester, G. R., Emery, P., Firestein, G. S., Kavanaugh, A., McInnes, I. B., Solomon, D. H., Strand, V., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.1 · Cited by 2,480 · see citing works

Genetics of rheumatoid arthritis contributes to biology and drug discovery

the RACI consortium, Okada, Y., the GARNET consortium, Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., Kochi, Y., Ohmura, K., et al. (2014) · Nature · doi:10.1038/nature12873 · Cited by 2,310 · see citing works

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Scher, J. U., Sczesnak, A., Longman, R. S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E. G., Abramson, S. B., et al. (2013) · eLife · doi:10.7554/elife.01202 · Cited by 2,047 · see citing works

The non-canonical NF-κB pathway in immunity and inflammation

Sun, S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.52 · Cited by 1,911 · see citing works

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Guo, Q., Wang, Y., Xu, D., Nossent, J. C., Pavlos, N. J., & Xu, J. (2018) · Bone Research · doi:10.1038/s41413-018-0016-9 · Cited by 1,829 · see citing works

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

Zhang, X., Zhang, D., Jia, H., Feng, Q., Wang, D., Liang, D., Wu, X., Li, J., Tang, L., Li, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3914 · Cited by 1,690 · see citing works

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

Harding, S. D., Sharman, J. L., Faccenda, E., Southan, C., Pawson, A. J., Ireland, S. M., Gray, A. J. G., Bruce, L., Alexander, S. P. H., Anderton, S. M., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1121 · Cited by 1,644 · see citing works

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Zhang, F., Wei, K., Slowikowski, K., Fonseka, C. Y., Rao, D. A., Kelly, S., Goodman, S. M., Tabechian, D. A., Hughes, L. B., Salomon-Escoto, K., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0378-1 · Cited by 1,380 · see citing works

Pathogenetic insights from the treatment of rheumatoid arthritis

McInnes, I. B., & Schett, G. A. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31472-1 · Cited by 1,353 · see citing works

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works

Immunopathogenesis of Rheumatoid Arthritis

Firestein, G. S., & McInnes, I. B. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.006 · Cited by 1,301 · see citing works

Damage-associated molecular patterns in inflammatory diseases

Roh, J. S., & Sohn, D. H. (2018) · Immune Network · doi:10.4110/in.2018.18.e27 · Cited by 1,261 · see citing works

Human autoimmune diseases: a comprehensive update

Wang, L., Wang, F., & Gershwin, M. E. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12395 · Cited by 1,201 · see citing works

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Rao, D. A., Gurish, M. F., Marshall, J. L., Slowikowski, K., Fonseka, C. Y., Liu, Y., Donlin, L. T., Henderson, L. A., Wei, K., Mizoguchi, F., et al. (2017) · Nature · doi:10.1038/nature20810 · Cited by 1,125 · see citing works

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

Tabas, I., & Glass, C. K. (2013) · Science · doi:10.1126/science.1230720 · Cited by 1,093 · see citing works

Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis

Koopman, F. A., Chavan, S. S., Miljko, S., Grazio, S., Sokolovic, S., Schuurman, P. R., Mehta, A. D., Levine, Y. A., Faltys, M., Zitnik, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605635113 · Cited by 1,024 · see citing works

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

Schett, G., & Gravallese, E. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.153 · Cited by 947 · see citing works

Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis

Lin, Y., Anzaghe, M., & Schülke, S. (2020) · Cells · doi:10.3390/cells9040880 · Cited by 967 · see citing works

Rheumatoid arthritis

Matteo, A. D., Bathon, J. M., & Emery, P. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01525-8 · Cited by 873 · see citing works

Rheumatoid Arthritis: A Brief Overview of the Treatment

Bullock, J., Rizvi, S. A. A., Saleh, A., Ahmed, S., Do, D. P., Ansari, R. A., & Ahmed, J. (2018) · Medical Principles and Practice · doi:10.1159/000493390 · Cited by 778 · see citing works

Oral microbiomes: more and more importance in oral cavity and whole body

Gao, L., Xu, T., Huang, G., Jiang, S., Gu, Y., & Chen, F. (2018) · Protein & Cell · doi:10.1007/s13238-018-0548-1 · Cited by 770 · see citing works

The oral microbiome: Role of key organisms and complex networks in oral health and disease

Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works

Melatonin: Buffering the Immune System

Carrillo‐Vico, A., Lardone, P. J., Álvarez‐Sánchez, N., Rodríguez-Rodríguez, A., & Guerrero, J. M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14048638 · Cited by 744 · see citing works

Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Chen, Z., Bözec, A., Ramming, A., & Schett, G. A. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0109-2 · Cited by 720 · see citing works

Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

Maeda, Y., Kurakawa, T., Umemoto, E., Motooka, D., Ito, Y., Gotoh, K., Hirota, K., Matsushita, M., Furuta, Y., Narazaki, M., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39783 · Cited by 686 · see citing works

Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

Chen, X., Yao, Q., Gu, X., Shi, Q., Yuan, X., Chu, Q., Bao, Z., Lu, J., & Li, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01468-7 · Cited by 753 · see citing works

The effects of acute psychological stress on circulating and stimulated inflammatory markers: a systematic review and meta-analysis

Marsland, A. L., Walsh, C., Lockwood, K., & John-Henderson, N. A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.01.011 · Cited by 691 · see citing works

Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases

Schwartz, D. M., Bonelli, M., Gadina, M., & O'Shea, J. J. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.167 · Cited by 648 · see citing works

Molecular mimicry and autoimmunity

Rojas, M., Restrepo-Jiménez, P., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., & Anaya, J.-M. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.012 · Cited by 627 · see citing works

The Role of M1/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis

Cutolo, M., Campitiello, R., Gotelli, E., & Soldano, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.867260 · Cited by 651 · see citing works

Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells

Jang, S., Kwon, E.-J., & Lee, J. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020905 · Cited by 621 · see citing works

Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases

Clark, J. D., Flanagan, M. E., & Telliez, J. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401490p · Cited by 615 · see citing works

Hypoxia, oxidative stress and inflammation

McGarry, T., Biniecka, M., Veale, D. J., & Fearon, U. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.042 · Cited by 610 · see citing works

NF‐κB signaling in inflammation and cancer

Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 615 · see citing works

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

Blevins, H. M., Xu, Y., Biby, S., & Zhang, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.879021 · Cited by 587 · see citing works

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

Zuo, L., Prather, E. R., Stetskiv, M., Garrison, D. E., Meade, J. R., Peace, T. I., & Zhou, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184472 · Cited by 545 · see citing works

Mechanisms of joint destruction in rheumatoid arthritis — immune cell–fibroblast–bone interactions

Komatsu, N., & Takayanagi, H. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00793-5 · Cited by 551 · see citing works

Notch signalling drives synovial fibroblast identity and arthritis pathology

Wei, K., Korsunsky, I., Marshall, J. L., Gao, A., Watts, G. F. M., Major, T., Croft, A. P., Watts, J., BLAZAR, P. E., Lange, J. K., et al. (2020) · Nature · doi:10.1038/s41586-020-2222-z · Cited by 538 · see citing works

MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

Juge, P., Lee, J. S., Ebstein, E., Furukawa, H., Dobrinskikh, E., Gazal, S., Kannengiesser, C., Ottaviani, S., Oka, S., Tohma, S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1801562 · Cited by 521 · see citing works

Cytokines in rheumatoid arthritis — shaping the immunological landscape

McInnes, I. B., Buckley, C. D., & Isaacs, J. D. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.171 · Cited by 504 · see citing works

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

Zhang, H., Lin, C., Zeng, C., Wang, Z., Wang, H., Lu, J., Liu, X., Shao, Y. X., Zhao, C. M., Pan, J., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213450 · Cited by 500 · see citing works

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

Tajik, N., Frech, M., Schulz, O., Schälter, F., Lucas, S., Azizov, V., Dürholz, K., Steffen, F., Omata, Y., Rings, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15831-7 · Cited by 504 · see citing works

Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: A review

Zhu, F., Du, B., & Xu, B. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1251390 · Cited by 495 · see citing works

Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Ding, Q., Hu, W., Wang, R., Yang, Q., Zhu, M., Li, M., Cai, J., Rose, P., Mao, J., & Zhu, Y. Z. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01331-9 · Cited by 520 · see citing works

Nonclassical Monocytes in Health and Disease

Narasimhan, P. B., Marcovecchio, P., Hamers, A. A. J., & Hedrick, C. C. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053119 · Cited by 474 · see citing works

Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization

Yang, Y., Guo, L., Wang, Z., Liu, P., Liu, X., Ding, J., & Zhou, W. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120390 · Cited by 503 · see citing works

Mechanisms of Autoantibody-Induced Pathology

Ludwig, R. J., Vanhoorelbeke, K., Leypoldt, F., Kaya, Z., Bieber, K., McLachlan, S. M., Komorowski, L., Luo, J., Cabral-Marques, O., Hammers, C. M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00603 · Cited by 475 · see citing works

Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis

Scher, J. U., Úbeda, C., Equinda, M. J., Khanin, R., Buischi, Y. D. P., Viale, A. J., Lipuma, L., Attur, M. G., Pillinger, M. H., Weissmann, G., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34539 · Cited by 465 · see citing works

Janus kinase inhibitors in autoimmune diseases

O’Shea, J. J., Kontzias, A., Yamaoka, K., Tanaka, Y., & Laurence, A. D. J. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202576 · Cited by 458 · see citing works

Tumour‐associated macrophages act as a slow‐release reservoir of nano‐therapeutic Pt(IV) pro‐drug

Miller, M. A., Zheng, Y.-R., Gadde, S., Pfirschke, C., Zope, H., Engblom, C., Kohler, R. H., Iwamoto, Y., Yang, K. S., Askevold, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms9692 · Cited by 441 · see citing works

Macrophage M1/M2 polarization and rheumatoid arthritis: A systematic review

Tardito, S., Martinelli, G., Soldano, S., Paolino, S., Pacini, G., Patanè, M., Alessandri, E., Smith, V. M., & Cutolo, M. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102397 · Cited by 441 · see citing works

Metagenome-wide association studies: fine-mining the microbiome

Wang, J., & Jia, H. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.83 · Cited by 429 · see citing works

The role of neutrophils and NETosis in autoimmune and renal diseases

Gupta, S., & Kaplan, M. J. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.71 · Cited by 433 · see citing works

Macrophages: The Good, the Bad, and the Gluttony

Ross, E. A., Devitt, A., & Johnson, J. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708186 · Cited by 436 · see citing works

The Gut Microbiota in Immune-Mediated Inflammatory Diseases

Forbes, J. D., Domselaar, G. V., & Bernstein, C. N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01081 · Cited by 430 · see citing works

The spectrum of T cell metabolism in health and disease

Bantug, G. R., Galluzzi, L., Kroemer, G., & Hess, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.99 · Cited by 421 · see citing works

Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Hu, F., Jiang, X. W., Guo, C., Li, Y., Chen, S., Zhang, W., Du, Y., Wang, P., Zheng, X., Fang, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15700-3 · Cited by 419 · see citing works

Tocilizumab: A review in rheumatoid arthritis

Scott, L. J. (2017) · Drugs · doi:10.1007/s40265-017-0829-7 · Cited by 419 · see citing works

Obesity, Fat Mass and Immune System: Role for Leptin

Francisco, V., Pino, J., Campos-Cabaleiro, V., Ruiz-Fernández, C., Mera, A., Gonzalez-Gay, M. A., Gómez, R., & Gualillo, O. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00640 · Cited by 411 · see citing works

How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy

Schett, G., Elewaut, D., McInnes, I. B., Dayer, J.-M., & Neurath, M. F. (2013) · Nature Medicine · doi:10.1038/nm.3260 · Cited by 406 · see citing works

Beyond the joints, the extra-articular manifestations in rheumatoid arthritis

Conforti, A., Cola, I. D., Pavlych, V., Ruscitti, P., Berardicurti, O., Ursini, F., Giacomelli, R., & Cipriani, P. (2020) · Autoimmunity Reviews · doi:10.1016/j.autrev.2020.102735 · Cited by 409 · see citing works

Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis.

Gibofsky, A. (2012) · PubMed · Cited by 409 · see citing works

Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis

Pianta, A., Arvikar, S. L., Strle, K., Drouin, E. E., Wang, Q., Costello, C. E., & Steere, A. C. (2016) · Arthritis & Rheumatology · doi:10.1002/art.40003 · Cited by 405 · see citing works

Human CD56bright NK Cells: An Update

Michel, T., Poli, A., Cuapio, A., Briquemont, B., Iserentant, G., Ollert, M. W., & Zimmer, J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502570 · Cited by 395 · see citing works

Androgen-Induced Immunosuppression

Bupp, M. G., & Jørgensen, T. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00794 · Cited by 393 · see citing works

Classical and Paradoxical Effects of TNF-α on Bone Homeostasis

Osta, B., Benedetti, G., & Miossec, P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00048 · Cited by 391 · see citing works

Tumour necrosis factor signalling in health and disease

Holbrook, J. A., Reyna, S. J. L., Jarosz-Griffiths, H., & McDermott, M. (2019) · F1000Research · doi:10.12688/f1000research.17023.1 · Cited by 379 · see citing works

Epstein-Barr Virus and Systemic Autoimmune Diseases

Houen, G., & Trier, N. H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.587380 · Cited by 381 · see citing works

The spectrum of giant cell arteritis and polymyalgia rheumatica: revisiting the concept of the disease

Dejaco, C., Duftner, C., Buttgereit, F., Matteson, E. L., & Dasgupta, B. (2016) · Lara D. Veeken · doi:10.1093/rheumatology/kew273 · Cited by 369 · see citing works

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

Stephenson, W., Donlin, L. T., Butler, A., Rozo, C. T., Bracken, B., Rashidfarrokhi, A., Goodman, S. M., Ivashkiv, L. B., Bykerk, V. P., Orange, D. E., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02659-x · Cited by 367 · see citing works

Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs

Schett, G. A., McInnes, I. B., & Neurath, M. F. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1909094 · Cited by 362 · see citing works

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

Navegantes, K. C., Gomes, R. D. S., Pereira, P. A., Czaikoski, P. G., Azevedo, C., & Monteiro, M. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1141-8 · Cited by 340 · see citing works

Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility

Chowdhury, C. S., Giaglis, S., Walker, U. A., Buser, A. S., Hahn, S., & Hasler, P. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4579 · Cited by 352 · see citing works

Rheumatoid arthritis and cardiovascular disease

Crowson, C. S., Liao, K. P., Davis, J. M., Solomon, D. H., Matteson, E. L., Knutson, K. L., Hlatky, M. A., & Gabriel, S. E. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.07.010 · Cited by 352 · see citing works

Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health

Kehrer, J. P., & Klotz, L. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1074159 · Cited by 337 · see citing works

Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management

Kadura, S., & Raghu, G. (2021) · European Respiratory Review · doi:10.1183/16000617.0011-2021 · Cited by 337 · see citing works

Oxidative Stress Relevance in the Pathogenesis of the Rheumatoid Arthritis: A Systematic Review

Quiñonez-Flores, C. M., González‐Chávez, S. A., Nájera, D. D. R., & Pacheco‐Tena, C. (2016) · BioMed Research International · doi:10.1155/2016/6097417 · Cited by 335 · see citing works

The role of autoantibodies in the pathophysiology of rheumatoid arthritis

Derksen, V. F. A. M., Huizinga, T. W. J., & van der Woude, D. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0627-z · Cited by 330 · see citing works

Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles

Li, R., He, Y., Zhu, Y., Jiang, L., Zhang, S., Qin, J., Wu, Q., Dai, W., Shen, S., Pang, Z., et al. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b03439 · Cited by 329 · see citing works

Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies

Kleyer, A., Finzel, S., Rech, J., Manger, B., Krieter, M., Faustini, F., Araujo, E., Hueber, A. J., Steffen, U., Engelke, K., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202958 · Cited by 328 · see citing works

Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis

Horta‐Baas, G., Romero-Figueroa, M. D. S., Montiel-Jarquín, Á. J., Pizano-Zárate, M. L., Garcı́a-Mena, J., & Ramírez‐Durán, N. (2017) · Journal of Immunology Research · doi:10.1155/2017/4835189 · Cited by 328 · see citing works

Physical activity and autoimmune diseases: Get moving and manage the disease

Sharif, Κ., Watad, ‬., Bragazzi, N. L., Lichtbroun, M., Amital, H., & Shoenfeld, Y. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.11.010 · Cited by 325 · see citing works

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

Pfeifle, R., Rothe, T., Ipseiz, N., Scherer, H. U., Culemann, S., Steffen, U., Ackermann, J. A., Seefried, M., Kleyer, A., Uderhardt, S., et al. (2016) · Nature Immunology · doi:10.1038/ni.3579 · Cited by 320 · see citing works

Crosstalk Between Gut Microbiota and Innate Immunity and Its Implication in Autoimmune Diseases

Jiao, Y., Wu, L., Huntington, N. D., & Zhang, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00282 · Cited by 321 · see citing works

C-reactive protein and implications in rheumatoid arthritis and associated comorbidities

Pope, J. E., & Choy, E. H. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.11.005 · Cited by 320 · see citing works

Nociceptive neurons detect cytokines in arthritis

Schaible, H. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0470-8 · Cited by 317 · see citing works

Early Diagnosis and Treatment of Rheumatoid Arthritis

Littlejohn, E., & Monrad, S. U. (2018) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2018.02.010 · Cited by 315 · see citing works

The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function

Lasica, A. M., Ksiazek, M., Madej, M., & Potempa, J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00215 · Cited by 312 · see citing works

Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity

Brown, E., Kenny, D. J., & Xavier, R. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041841 · Cited by 310 · see citing works

Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications

Murdaca, G., Tonacci, A., Negrini, S. M., Greco, M., Borro, M., Puppo, F., & Gangemi, S. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102350 · Cited by 308 · see citing works

Emerging cell and cytokine targets in rheumatoid arthritis

Burmester, G. R., Feist, E., & Dörner, T. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.168 · Cited by 307 · see citing works

Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

Puhm, F., Afonyushkin, T., Resch, U., Obermayer, G., Rohde, M., Penz, T., Schuster, M., Wagner, G., Rendeiro, A. F., Melki, I., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314601 · Cited by 306 · see citing works

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

Boyle, D. L., Soma, K., Hodge, J., Kavanaugh, A., Mandel, D. R., Mease, P. J., Shurmur, R., Singhal, A. K., Wei, N., Rosengren, S., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-206028 · Cited by 302 · see citing works

Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, for the Treatment of Rheumatoid Arthritis in Open-label, Longterm Extension Studies

Wollenhaupt, J., Silverfield, J. C., Lee, E. B., Curtis, J. R., Wood, S. P., Soma, K., Nduaka, C. I., Benda, B., Gruben, D. C., Nakamura, H., et al. (2014) · The Journal of Rheumatology · doi:10.3899/jrheum.130683 · Cited by 301 · see citing works

Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction

Boissier, M., Semerano, L., Challal, S., Saidenberg-Kermanac’h, N., & Falgarone, G. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.05.021 · Cited by 299 · see citing works

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

Liu, B., Wang, J., Li, Y., Li, K., & Zhang, Q. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03018-6 · Cited by 298 · see citing works

Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions

Schett, G. A., Emery, P., Tanaka, Y., Burmester, G. R., Pisetsky, D. S., Naredo, E., Fautrel, B., & van Vollenhoven, R. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209201 · Cited by 297 · see citing works

Cell-Free DNA as a Biomarker in Autoimmune Rheumatic Diseases

Duvvuri, B., & Lood, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00502 · Cited by 282 · see citing works

Rheumatoid arthritis

Klareskog, L., Catrina, A. I., & Paget, S. A. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60008-8 · Cited by 787 · see citing works

Immunologic Mechanisms in the Pathogenesis of Rheumatoid Arthritis

Firestein, G. S. (2005) · JCR Journal of Clinical Rheumatology · doi:10.1097/01.rhu.0000166673.34461.33 · Cited by 244 · see citing works

Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis

Chen, S., Lin, G., Chen, J.-W., Wang, K., Tien, C., Hu, C.-F., Chang, C.-N., Hsu, W.-F., Fan, H., & Sytwu, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061332 · Cited by 67 · see citing works

Therapeutic strategies for rheumatoid arthritis

Smolen, J. S., & Steiner, G. E. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1109 · Cited by 915 · see citing works

An introduction to rheumatoid arthritis

Zvaifler, N. J. (1989) · Arthritis & Rheumatism · doi:10.1002/anr.1790020310 · Cited by 8 · see citing works