The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Altered blood B lymphocyte homeostasis in systemic sclerosis: Expanded naive B cells and diminished but activated memory B cells
Abstract
Objective: To determine phenotypic and functional abnormalities of blood B cell subsets in patients with systemic sclerosis (SSc). Methods: Cell surface marker expression was determined by flow cytometry. Spontaneous apoptosis was evaluated by annexin V expression with flow cytometric analysis. IgG production by isolated IgD− memory B cells was examined by enzyme‐linked immunosorbent assay. Results: The numbers of blood CD27− naive B cells from SSc patients were increased compared with normal control cells, while memory B cells expressing medium levels of CD27 and plasmablasts expressing high levels of CD27 were reduced. In contrast, plasmablasts were the predominant population in patients with systemic lupus erythematosus (SLE). Memory B cells in SSc showed increased expression of activation markers, including CD80, CD86, and CD95, relative to normal controls. Consistent with CD95 up‐regulation, SSc memory B cells exhibited augmented spontaneous apoptosis after 24‐hour incubation; augmented apoptosis may explain the reduced memory B cell number. Nonetheless, isolated IgD− SSc memory B cells treated with stimuli had an enhanced ability to produce IgG. Furthermore, expression of CD19, a critical signal transduction molecule of B cells that regulates autoantibody production, was significantly increased in memory B cells as well as in naive B cells in SSc. In contrast, CD19 expression was decreased in SLE B cells. Conclusion: SSc patients have distinct abnormalities of blood homeostasis and B cell compartments, characterized by expanded naive B cells and activated but diminished memory B cells. Our results suggest that CD19 overexpression in SSc memory B cells is related to their hyperreactivity.
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Preliminary criteria for the classification of systemic sclerosis (scleroderma)
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From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins
Korganow, A.-S., Ji, H., Mangialaio, S., Duchatelle, V., Pelanda, R., Martin, T., Degott, C., Kikutani, H., Rajewsky, K., Pasquali, J.-L., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80045-x · Cited by 690
Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus
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An open study of B lymphocyte depletion in systemic lupus erythematosus
Leandro, M. J., Edwards, J. C., Cambridge, G., Ehrenstein, M. R., & Isenberg, D. A. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10541 · Cited by 576
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Cited by
Systemic sclerosis: a prototypic multisystem fibrotic disorder
Varga, J., & Abraham, D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31139 · Cited by 1,163
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
B‐lymphocyte contributions to human autoimmune disease
Yanaba, K., Bouaziz, J., Matsushita, T., Magro, C. M., St.Clair, E. W., & Tedder, T. F. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00646.x · Cited by 326
François, A., Chatelus, E., Wachsmann, D., Sibilia, J., Bahram, S., Alsaleh, G., & Gottenberg, J.-E. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4352 · Cited by 149
Vascular involvement in systemic sclerosis (scleroderma)
Postlethwaite, Pattanaik, D., & Brown, M. (2011) · Journal of Inflammation Research · doi:10.2147/jir.s18145 · Cited by 119
Metadata
- Authors
- Sato, S., Fujimoto, M., Hasegawa, M., & Takehara, K.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2004-06
- Volume
- 50
- Issue
- 6
- Pages
- 1918-1927
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2027949435
- Cited by
- 317
- References
- 38
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
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