The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
Open accessAbstract
Objective: The functional role of HLA class II molecules in the pathogenesis of rheumatoid arthritis (RA) is unclear. HLA class II molecules are involved in the interaction between T and B lymphocytes required for long‐lived B cell responses and generation of high‐affinity IgG antibodies. We undertook this study to investigate the relationship between HLA class II gene polymorphisms and RA‐specific IgG antibodies against cyclic citrullinated peptides (anti‐CCP antibodies). Methods: High‐resolution HLA–DR and DQ typing and anti–CCP‐2 antibody testing were performed on 268 RA patients from the Early Arthritis Clinic cohort at the Department of Rheumatology of the Leiden University Medical Center. The presence of anti‐CCP antibodies was analyzed in carriers of the different DR and DQ alleles. Disease progression was measured over a period of 4 years by scoring radiographs of the hands and feet using the Sharp/van der Heijde method. Results: Carriership of the individual alleles HLA–DRB1*0401, DRB1*1001, DQB1*0302, and DQB1*0501 was associated with the presence of anti‐CCP antibodies. Carriers of DQ–DR genotypes containing proposed RA susceptibility alleles were significantly more often anti‐CCP antibody positive. Carriership of one or two HLA–DRB1 shared epitope (SE) alleles was significantly associated with production of anti‐CCP antibodies (odds ratio [OR] 3.3, 95% confidence interval [95% CI] 1.8–6.0 and OR 13.3, 95% CI 4.6–40.4, respectively). An increased rate of joint destruction was observed in SE+, anti‐CCP+ patients (mean Sharp score 7.6 points per year) compared with that in SE−, anti‐CCP+ patients (2.4 points per year) (P = 0.04), SE+, anti‐CCP− patients (1.6 points per year) (P < 0.001), and SE−, anti‐CCP− patients (1.6 points per year) (P < 0.001). Conclusion: HLA class II RA susceptibility alleles are associated with production of anti‐CCP antibodies. Moreover, more severe disease progression is found in RA patients with both anti‐CCP antibodies and SE alleles.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Arnett, F. C., Edworthy, S. M., Bloch, D. A., Mcshane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A., Kaplan, S. R., Liang, M. H., Luthra, H. S., et al. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310302 · Cited by 19,752
Revised Criteria for the Classification of Rheumatoid Arthritis
Arnett, F. C. (1990) · Orthopaedic Nursing · doi:10.1097/00006416-199003000-00011 · Cited by 7,723
Gregersen, P. K., Silver, J., & Winchester, R. J. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780301102 · Cited by 2,599
Rantapää‐Dahlqvist, S., de Jong, B. A. W., Berglin, E., Hallmans, G., Wadell, G., Stenlund, H., Sundin, U., & van Venrooij, W. J. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11223 · Cited by 1,953
Self-citationSchellekens, G. A., Visser, H., De Jong, B. A. W., Van Den Hoogen, F. H. J., Hazes, J. M. W., Breedveld, F. C., & Van Venrooij, W. J. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1<155::aid-anr20>3.0.co;2-3 · Cited by 1,450
Self-citationSchellekens, G. A., de Jong, B. A., van den Hoogen, F. H., van de Putte, L. B., & van Venrooij, W. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1316 · Cited by 1,450
Self-citationSuzuki, A., Yamada, R., Chang, X., Tokuhiro, S., Sawada, T., Suzuki, M., Nagasaki, M., Nakayama-Hamada, M., Kawaida, R., Ono, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1206 · Cited by 1,168
How to diagnose rheumatoid arthritis early: A prediction model for persistent (erosive) arthritis
Visser, H., le Cessie, S., Vos, K., Breedveld, F. C., & Hazes, J. M. W. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10117 · Cited by 731
Self-citationHill, J. A., Southwood, S., Sette, A., Jevnikar, A. M., Bell, D. A., & Cairns, E. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.538 · Cited by 713
Masson-Bessière, C., Sebbag, M., Girbal-Neuhauser, E., Nogueira, L., Vincent, C., Senshu, T., & Serre, G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.4177 · Cited by 643
Cited by
Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30173-8 · Cited by 4,870
Klareskog, L., Stolt, P., Lundberg, K., Källberg, H., Bengtsson, C., Grunewald, J., Rönnelid, J., Erlandsson Harris, H., Ulfgren, A., Rantapää‐Dahlqvist, S., et al. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21575 · Cited by 1,515
Huizinga, T. W. J., Amos, C. I., van der Helm‐van Mil, A. H. M., Chen, W., van Gaalen, F. A., Jawaheer, D., Schreuder, G. M. T., Wener, M., Breedveld, F. C., Ahmad, N., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21385 · Cited by 593
Self-citationB-cell targeting in rheumatoid arthritis and other autoimmune diseases
Edwards, J. C. W., & Cambridge, G. (2006) · Nature Reviews Immunology · doi:10.1038/nri1838 · Cited by 507
Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
van der Helm-van Mil, A. H., Verpoort, K. N., Breedveld, F. C., Toes, R. E., & Huizinga, T. W. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1767 · Cited by 485
Self-citation
Metadata
- Authors
- Van Gaalen, F. A., Van Aken, J., Huizinga, T. W. J., Schreuder, G. M. T., Breedveld, F. C., Zanelli, E., Van Venrooij, W. J., Verweij, C. L., Toes, R. E. M., & De Vries, R. R. P.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2004-07
- Volume
- 50
- Issue
- 7
- Pages
- 2113-2121
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2123361363
- Cited by
- 393
- References
- 24
- FWCI
- 20.42
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. https://app.cochat.ai/papers/10.1002/art.20316
- The paper
- Van Gaalen, F. A., Van Aken, J., Huizinga, T. W. J., Schreuder, G. M. T., Breedveld, F. C., Zanelli, E., Van Venrooij, W. J., Verweij, C. L., Toes, R. E. M., & De Vries, R. R. P. (2004). Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.20316
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
