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Cited by 289

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Cartilage repair using bone morphogenetic protein 4 and muscle‐derived stem cells

Kuroda, Ryosuke, Usas, Arvydas, Kubo, Seiji, Corsi, Karin, Peng, Hairong, Rose, Tim, Cummins, James, Fu, Freddie H., Huard, Johnny·2006·Arthritis & Rheumatism
DOI 10.1002/art.21632
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Abstract

Objective: Muscle‐derived stem cells (MDSCs) isolated from mouse skeletal muscle exhibit long‐time proliferation, high self‐renewal, and multipotent differentiation. This study was undertaken to investigate the ability of MDSCs that were retrovirally transduced to express bone morphogenetic protein 4 (BMP‐4) to differentiate into chondrocytes in vitro and in vivo and enhance articular cartilage repair. Methods: Using monolayer and micromass pellet culture systems, we evaluated the in vitro chondrogenic differentiation of LacZ‐ and BMP‐4–transduced MDSCs with or without transforming growth factor β1 (TGFβ1) stimulation. We used a nude rat model of a full‐thickness articular cartilage defect to assess the duration of LacZ transgene expression and evaluate the ability of transplanted cells to acquire a chondrocytic phenotype. We evaluated cartilage repair macroscopically and histologically 4, 8, 12, and 24 weeks after surgery, and performed histologic grading of the repaired tissues. Results: BMP‐4–expressing MDSCs acquired a chondrocytic phenotype in vitro more effectively than did MDSCs expressing only LacZ; the addition of TGFβ1 did not alter chondrogenic differentiation of the BMP‐4–transduced MDSCs. LacZ expression within the repaired tissue continued for up to 12 weeks. Four weeks after surgery, we detected donor cells that coexpressed β‐galactosidase and type II collagen. Histologic scoring of the defect sites 24 weeks after transplantation revealed significantly better cartilage repair in animals that received BMP‐4–transduced MDSCs than in those that received MDSCs expressing only LacZ. Conclusion: Local delivery of BMP‐4 by genetically engineered MDSCs enhanced chondrogenesis and significantly improved articular cartilage repair in rats.

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Metadata

Authors
Kuroda, R., Usas, A., Kubo, S., Corsi, K., Peng, H., Rose, T., Cummins, J., Fu, F. H., & Huard, J.
Venue
Arthritis & Rheumatism
Publisher
Wiley
Published
2006-01-30
Volume
54
Issue
2
Pages
433-442
ISSN
  • 0004-3591 (ISSN-L)
  • 1529-0131
DOI
10.1002/art.21632
OpenAlex
W1999013968
Cited by
289
References
45
FWCI
16.14
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Cartilage repair using bone morphogenetic protein 4 and muscle‐derived stem cells. https://app.cochat.ai/papers/10.1002/art.21632
The paper
Kuroda, R., Usas, A., Kubo, S., Corsi, K., Peng, H., Rose, T., Cummins, J., Fu, F. H., & Huard, J. (2006). Cartilage repair using bone morphogenetic protein 4 and muscle‐derived stem cells. Arthritis & Rheumatism. https://doi.org/10.1002/art.21632

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.