Engineering cartilage tissue
Open accessAbstract
Cartilage tissue engineering is emerging as a technique for the regeneration of cartilage tissue damaged due to disease or trauma. Since cartilage lacks regenerative capabilities, it is essential to develop approaches that deliver the appropriate cells, biomaterials, and signaling factors to the defect site. The objective of this review is to discuss the approaches that have been taken in this area, with an emphasis on various cell sources, including chondrocytes, fibroblasts, and stem cells. Additionally, biomaterials and their interaction with cells and the importance of signaling factors on cellular behavior and cartilage formation will be addressed. Ultimately, the goal of investigators working on cartilage regeneration is to develop a system that promotes the production of cartilage tissue that mimics native tissue properties, accelerates restoration of tissue function, and is clinically translatable. Although this is an ambitious goal, significant progress and important advances have been made in recent years.
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Engineered scaffolds are especially valuable in joint repair, offering structural support while promoting cellular proliferation and matrix deposition.
“Engineered scaffolds are especially valuable in joint repair, as they offer structural support while promoting cellular proliferation and matrix deposition [30,31].”
Cites
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Controlled Degradation and Mechanical Behavior of Photopolymerized Hyaluronic Acid Networks
Burdick, J. A., Chung, C., Jia, X., Randolph, M. A., & Langer, R. (2005) · Biomacromolecules · doi:10.1021/bm049508a · Cited by 777 · see citing works
Self-citationSlevin, M., Kumar, S., & Gaffney, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109443200 · Cited by 346 · see citing works
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Silk fibroin as a functional biomaterial for tissue engineering
Sun, W., Gregory, D. A., Tomeh, M. A., & Zhao, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031499 · Cited by 552 · see citing works
Petrenko, Y. A., Ivanov, R. V., Petrenko, A. Y., & Lozinsky, V. I. (2011) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-011-4323-6 · Cited by 78 · see citing works
Goulian, A. J., Goldstein, B., & Saad, M. A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062061 · Cited by 25 · see citing works
“Engineered scaffolds are especially valuable in joint repair, as they offer structural support while promoting cellular proliferation and matrix deposition [30,31].”
- Authors
- Chung, C., & Burdick, J. A.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Burdick, Jason A.
- ORCID
- Burdick, Jason A.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 60
- Issue
- 2
- Pages
- 243-262
- ISSN
- 0169-409X (ISSN-L)
- PMC
- PMC2230638
- OpenAlex
- W1987032519
- Cited by
- 760
- References
- 3
- Citations by year
- 2026: 9 · 2025: 29 · 2024: 29 · 2023: 31 · 2022: 37 · 2021: 37 · 2020: 27 · 2019: 39 · 2018: 40 · 2017: 47 · 2016: 54 · 2015: 52 · 2014: 64 · 2013: 61 · 2012: 52
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institute of Dental and Craniofacial Research (K22DE015761)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- cartilage tissue engineering, cartilage regeneration, chondrocytes, fibroblasts, stem cells, biomaterials, cartilage defects, cell delivery
- MeSH terms
- Animals, Cartilage, Cell Differentiation, Fibroblasts, Humans, Stem Cells, Chondrocytes, Tissue Engineering, Intercellular Signaling Peptides and Proteins, Tissue Scaffolds
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