The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator
Abstract
Objective: To assess the effects of the prescription formulation of glucosamine sulfate (1,500 mg administered once daily) on the symptoms of knee osteoarthritis (OA) during a 6‐month treatment course. Methods: Three hundred eighteen patients were enrolled in this randomized, placebo‐controlled, double‐blind trial in which acetaminophen, the currently preferred medication for symptomatic treatment of OA, was used as a side comparator. Patients were randomly assigned to receive oral glucosamine sulfate 1,500 mg once daily (n = 106), acetaminophen 3 gm/day (n = 108), or placebo (n = 104). The primary efficacy outcome measure was the change in the Lequesne index after 6 months. Secondary parameters included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and response according to the Osteoarthritis Research Society International criteria. These outcome measures were assessed using an intent‐to‐treat analysis. Results: At baseline, the study patients had moderately severe OA symptoms (mean Lequesne index ∼11 points). Glucosamine sulfate was more effective than placebo in improving the Lequesne score, with a final decrease of 3.1 points, versus 1.9 with placebo (difference between glucosamine sulfate and placebo −1.2 [95% confidence interval −2.3, −0.8]) (P = 0.032). The 2.7‐point decrease with acetaminophen was not significantly different from that with placebo (difference −0.8 [95% confidence interval −1.9, 0.3]) (P = 0.18). Similar results were observed for the WOMAC. There were more responders to glucosamine sulfate (39.6%) and acetaminophen (33.3%) than to placebo (21.2%) (P = 0.004 and P = 0.047, respectively, versus placebo). Safety was good, and was comparable among groups. Conclusion: The findings of this study indicate that glucosamine sulfate at the oral once‐daily dosage of 1,500 mg is more effective than placebo in treating knee OA symptoms. Although acetaminophen also had a higher responder rate compared with placebo, it failed to show significant effects on the algofunctional indexes.
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Cites
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Cited by
Zhang, W., Moskowitz, R. W., Nuki, G., Abramson, S., Altman, R. D., Arden, N., Bierma-Zeinstra, S., Brandt, K. D., Croft, P., Doherty, M., et al. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.12.013 · Cited by 2,796
Machado, G. C., Maher, C. G., Ferreira, P. H., Pinheiro, M. B., Lin, C.-W. C., Day, R. O., McLachlan, A. J., & Ferreira, M. L. (2015) · BMJ · doi:10.1136/bmj.h1225 · Cited by 580
Wandel, S., Juni, P., Tendal, B., Nuesch, E., Villiger, P. M., Welton, N. J., Reichenbach, S., & Trelle, S. (2010) · BMJ · doi:10.1136/bmj.c4675 · Cited by 578
Type 2 diabetes mellitus and osteoarthritis
Veronese, N., Cooper, C., Reginster, J.-Y., Hochberg, M., Branco, J., Bruyère, O., Chapurlat, R., Al-Daghri, N., Dennison, E., Herrero-Beaumont, G., et al. (2019) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2019.01.005 · Cited by 258
Self-citationParacetamol versus placebo for knee and hip osteoarthritis
Leopoldino, A. O., Machado, G. C., Ferreira, P. H., Pinheiro, M. B., Day, R., McLachlan, A. J., Hunter, D. J., & Ferreira, M. L. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013273 · Cited by 167
Metadata
- Authors
- Herrero‐Beaumont, G., Ivorra, J. A. R., del Carmen Trabado, M., Blanco, F. J., Benito, P., Martín‐Mola, E., Paulino, J., Marenco, J. L., Porto, A., Laffon, A., Araújo, D., Figueroa, M., & Branco, J.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2007-01-30
- Volume
- 56
- Issue
- 2
- Pages
- 555-567
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2074339153
- Cited by
- 287
- References
- 41
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Herrero‐Beaumont, G., Ivorra, J. A. R., del Carmen Trabado, M., Blanco, F. J., Benito, P., Martín‐Mola, E., Paulino, J., Marenco, J. L., Porto, A., Laffon, A., Araújo, D., Figueroa, M., & Branco, J. (2007). Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator. Arthritis & Rheumatism. https://doi.org/10.1002/art.22371
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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