The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Lifetime risk of symptomatic knee osteoarthritis
Open accessAbstract
Objective: To estimate the lifetime risk of symptomatic knee osteoarthritis (OA), overall and stratified by sex, race, education, history of knee injury, and body mass index (BMI). Methods: The lifetime risk of symptomatic OA in at least 1 knee was estimated from logistic regression models with generalized estimating equations among 3,068 participants of the Johnston County Osteoarthritis Project, a longitudinal study of black and white women and men age ≥45 years living in rural North Carolina. Radiographic, sociodemographic, and symptomatic knee data measured at baseline (1990–1997) and first followup (1999–2003) were analyzed. Results: The lifetime risk of symptomatic knee OA was 44.7% (95% confidence interval [95% CI] 40.0–49.3%). Cohort members with history of a knee injury had a lifetime risk of 56.8% (95% CI 48.4–65.2%). Lifetime risk rose with increasing BMI, with a risk of 2 in 3 among those who were obese. Conclusion: Nearly half of the adults in Johnston County will develop symptomatic knee OA by age 85 years, with lifetime risk highest among obese persons. These current high risks in Johnston County may suggest similar risks in the general US population, especially given the increase in 2 major risk factors for knee OA, aging, and obesity. This underscores the immediate need for greater use of clinical and public health interventions, especially those that address weight loss and self‐management, to reduce the impact of having knee OA.
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Cites
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Cited by
Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, C., Guyatt, G., Block, J., Callahan, L., Copenhaver, C., Dodge, C., Felson, D., et al. (2020) · Arthritis Care & Research · doi:10.1002/acr.24131 · Cited by 2,516
The epidemiology and impact of pain in osteoarthritis
Neogi, T. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.03.018 · Cited by 1,730
BMP signalling in skeletal development, disease and repair
Salazar, V. S., Gamer, L. W., & Rosen, V. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.12 · Cited by 822
Strategies for the prevention of knee osteoarthritis
Roos, E. M., & Arden, N. K. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.135 · Cited by 580
Barrios, J. A., Crossley, K. M., & Davis, I. S. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2010.03.040 · Cited by 261
Metadata
- Authors
- Murphy, L., Schwartz, T. A., Helmick, C. G., Renner, J. B., Tudor, G., Koch, G., Dragomir, A., Kalsbeek, W. D., Luta, G., & Jordan, J. M.
- Venue
- Arthritis Care & Research
- Publisher
- Wiley
- Published
- 2008-08-29
- Volume
- 59
- Issue
- 9
- Pages
- 1207-1213
- ISSN
- 0893-7524 (ISSN-L)
- 1529-0123
- OpenAlex
- W2011258258
- Cited by
- 1,051
- References
- 30
- FWCI
- 17.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Murphy, L., Schwartz, T. A., Helmick, C. G., Renner, J. B., Tudor, G., Koch, G., Dragomir, A., Kalsbeek, W. D., Luta, G., & Jordan, J. M. (2008). Lifetime risk of symptomatic knee osteoarthritis. Arthritis Care & Research. https://doi.org/10.1002/art.24021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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