The epidemiology and impact of pain in osteoarthritis

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · see citing works

Projections of Primary and Revision Hip and Knee Arthroplasty in the United States from 2005 to 2030

Kurtz, S. M., Ong, K. L., Lau, E., Mowat, F. S., & Halpern, M. T. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.f.00222 · Cited by 8,714 · see citing works

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291 · see citing works

Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee.

Bellamy, N., Buchanan, W. W., Goldsmith, C. H., Campbell, J., & Stitt, L. (1988) · PubMed · Cited by 7,688 · see citing works

Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II

Lawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H. K., Deyo, R. A., Gabriel, S. E., Hirsch, R., Hochberg, M. C., Hunder, G. G., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23176 · Cited by 5,500 · see citing works

Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short‐Form McGill Pain Questionnaire (SF‐MPQ), Chronic Pain Grade Scale (CPGS), Short Form‐36 Bodily Pain Scale (SF‐36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP)

Hawker, G. A., Mian, S., Kendzerska, T., & French, M. (2011) · Arthritis Care & Research · doi:10.1002/acr.20543 · Cited by 4,924 · see citing works

Neuronal plasticity: Increasing the gain in pain

Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781 · see citing works

Core outcome measures for chronic pain clinical trials: IMMPACT recommendations

Dworkin, R. H., Turk, D. C., Farrar, J. T., Haythornthwaite, J. A., Jensen, M. P., Katz, N. P., Kerns, R. D., Stucki, G., Allen, R. R., Bellamy, N., et al. (2005) · Pain · doi:10.1016/j.pain.2004.09.012 · Cited by 3,732 · see citing works

Core outcome domains for chronic pain clinical trials: IMMPACT recommendations

Turk, D. C., Dworkin, R. H., Allen, R. R., Bellamy, N., Brandenburg, N., Carr, D. B., Cleeland, C., Dionne, R., Farrar, J. T., Galer, B. S., et al. (2003) · Pain · doi:10.1016/j.pain.2003.08.001 · Cited by 3,510 · see citing works

Classification of chronic pain

Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952 · see citing works

The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis.

Roos, E. M., & Lohmander, S. L. (2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-64 · Cited by 2,361 · see citing works

Evidence for a central component of post-injury pain hypersensitivity

Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157 · see citing works

The prevalence of knee osteoarthritis in the elderly. the framingham osteoarthritis study

Felson, D. T., Naimark, A., Anderson, J. J., Kazis, L. E., Castelli, W. P., & Meenan, R. F. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780300811 · Cited by 1,620 · see citing works

The effects of specific medical conditions on the functional limitations of elders in the Framingham Study.

Guccione, A. A., Felson, D. T., Anderson, J. J., Anthony, J., Zhang, Y., Wilson, P. W. F., Kelly‐Hayes, M., Wolf, P. A., Kreger, B. E., & Kannel, W. B. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.3.351 · Cited by 1,580 · see citing works

Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care

Peat, G., McCarney, R., & Croft, P. (2001) · Annals of the Rheumatic Diseases · doi:10.1136/ard.60.2.91 · Cited by 1,338 · see citing works

Prevalence of Primary and Revision Total Hip and Knee Arthroplasty in the United States From 1990 Through 2002

Kurtz, S. M. (2005) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.d.02441 · Cited by 1,251 · see citing works

Pathogenesis and management of pain in osteoarthritis

Dieppe, P. A., & Lohmander, S. L. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71086-2 · Cited by 1,214 · see citing works

Osteoarthritis: Epidemiology

Arden, N., & Nevitt, M. C. (2006) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2005.09.007 · Cited by 1,137 · see citing works

Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: The arthritis, diet, and activity promotion trial

Messier, S. P., Loeser, R. F., Miller, G. D., Morgan, T. M., Rejeski, W. J., Sevick, M. A., Ettinger, W. H., Pahor, M., & Williamson, J. D. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20256 · Cited by 1,065 · see citing works

Lifetime risk of symptomatic knee osteoarthritis

Murphy, L. B., Schwartz, T. A., Helmick, C. G., Renner, J. B., Tudor, G., Koch, G. G., Dragomir, A., Kalsbeek, W. D., Luta, G., & Jordan, J. M. (2008) · Arthritis Care & Research · doi:10.1002/art.24021 · Cited by 1,055 · see citing works

Nociceptors—Noxious Stimulus Detectors

Woolf, C. J., & Ma, Q. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.016 · Cited by 1,053 · see citing works

Sensitization in patients with painful knee osteoarthritis

Arendt‐Nielsen, L., Nie, H., Laursen, M. B., Laursen, B. S., Madeleine, P., Simonsen, O. H., & Graven‐Nielsen, T. (2010) · Pain · doi:10.1016/j.pain.2010.04.003 · Cited by 992 · see citing works

The discordance between clinical and radiographic knee osteoarthritis: A systematic search and summary of the literature

Bedson, J., & Croft, P. R. (2008) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-9-116 · Cited by 951 · see citing works

Weight Loss Reduces the Risk for Symptomatic Knee Osteoarthritis in Women

Felson, D. T., Zhang, Y., Anthony, J. M., Naimark, A., & Anderson, J. J. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-7-535 · Cited by 928 · see citing works

Projections of US prevalence of arthritis and associated activity limitations

Hootman, J. M., & Helmick, C. G. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21562 · Cited by 888 · see citing works

OMERACT-OARSI Initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited.

Pham, T., van der Heijde, D. M. F. M., Altman, R. D., Anderson, J. J., Bellamy, N., Hochberg, M. C., Simon, L. S., Strand, V., Woodworth, T., & Dougados, M. (2004) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2004.02.001 · Cited by 849 · see citing works

Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S. (2001) · Science · doi:10.1126/science.1060952 · Cited by 842 · see citing works

Prevalence and most common causes of disability among adults - United States, 2005.

Brault, M. W., Hootman, J., Helmick, C. G., Theis, K. A., & Armour, B. S. (2009) · MMWR Morbidity and Mortality Weekly Report · Cited by 761 · see citing works

Prevalence of Hip Symptoms and Radiographic and Symptomatic Hip Osteoarthritis in African Americans and Caucasians: The Johnston County Osteoarthritis Project

Jordan, J. M., Helmick, C. G., Renner, J. B., LUTA, G., DRAGOMIR, A. D., Woodard, J., FANG, F., Schwartz, T. A., Nelson, A. E., ABBATE, L. M., et al. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.080677 · Cited by 739 · see citing works

Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee.

Hannan, M. T., Felson, D. T., & Pincus, T. (2000) · PubMed · Cited by 714 · see citing works

The Impact of Osteoarthritis

Buckwalter, J. A., Saltzman, C. L., & Brown, T. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000143938.30681.9d · Cited by 678 · see citing works

Prevalence of Symptomatic Hand Osteoarthritis and Its Impact on Functional Status among the Elderly: The Framingham Study

Zhang, Y. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf141 · Cited by 643 · see citing works

Increasing Prevalence of Knee Pain and Symptomatic Knee Osteoarthritis: Survey and Cohort Data

Nguyen, U., Zhang, Y., Zhu, Y., Niu, J., Zhang, B., & Felson, D. T. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-155-11-201112060-00004 · Cited by 615 · see citing works

Determinants of disability in osteoarthritis of the knee

McAlindon, T. E., Cooper, C., Kirwan, J. R., & Dieppe, P. A. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.4.258 · Cited by 548 · see citing works

The burden of musculoskeletal diseases in the United States

Yelin, E., Weinstein, S., & King, T. (2016) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2016.07.013 · Cited by 537 · see citing works

Understanding the pain experience in hip and knee osteoarthritis – an OARSI/OMERACT initiative

HAWKER, G. A., Stewart, L., French, M., Cibere, J., Jordan, J. M., MARCH, L. M., Suarez-Almazor, M. E., & Gooberman‐Hill, R. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.12.017 · Cited by 522 · see citing works

Mechanisms of Pain in Arthritis

Schaible, H., Ebersberger, A., & von Banchet, G. S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04234.x · Cited by 515 · see citing works

Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study

Haugen, I. K., Englund, M., Aliabadi, P., Niu, J., Clancy, M. M., Kvien, T. K., & Felson, D. T. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2011.150078 · Cited by 512 · see citing works

Prevalence of Disabilities and Associated Health Conditions Among Adults—United States, 1999

(2001) · JAMA · doi:10.1001/jama.285.12.1571-jwr0328-3-1 · Cited by 495 · see citing works

Signaling Pathways in Sensitization: Toward a Nociceptor Cell Biology

Hucho, T. B., & Levine, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.008 · Cited by 491 · see citing works

Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis

Suokas, A. K., Walsh, D. A., McWilliams, D. F., Condon, L. A., Moreton, B. J., Wylde, V., Arendt‐Nielsen, L., & Zhang, W. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.06.009 · Cited by 462 · see citing works

Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies

Neogi, T., Felson, D. T., Niu, J., Nevitt, M. C., Lewis, C. E., Aliabadi, P., Sack, B., Torner, J. C., Bradley, L. A., & Zhang, Y. (2009) · BMJ · doi:10.1136/bmj.b2844 · Cited by 460 · see citing works

Hip disability and osteoarthritis outcome scoreAn extension of the Western Ontario and McMaster Universities Osteoarthritis Index

Klässbo, M., Larsson, E., & Mannevik, E. (2003) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740310000409 · Cited by 454 · see citing works

How prior experience shapes placebo analgesia

Colloca, L., & Benedetti, F. (2006) · Pain · doi:10.1016/j.pain.2006.04.005 · Cited by 443 · see citing works

Factors associated with functional impairment in symptomatic knee osteoarthritis

Creamer, P., Lethbridge‐Cejku, M., & Hochberg, M. C. (2000) · Rheumatology · doi:10.1093/rheumatology/39.5.490 · Cited by 435 · see citing works

A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia

Vase, L., Riley, J. L., & Price, D. D. (2002) · Pain · doi:10.1016/s0304-3959(02)00205-1 · Cited by 434 · see citing works

Pain modulation: expectation, opioid analgesia and virtual pain

Fields, H. L. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62143-3 · Cited by 433 · see citing works

The genetic mediation of individual differences in sensitivity to pain and its inhibition

Mogil, J. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7744 · Cited by 433 · see citing works

Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients

Gwilym, S. E., Keltner, J. R., Warnaby, C. E., Carr, A. J., Chizh, B. A., Chessell, I. P., & Tracey, I. (2009) · Arthritis Care & Research · doi:10.1002/art.24837 · Cited by 431 · see citing works

Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review

Yusuf, E., Kortekaas, M. C., Watt, I., Huizinga, T. W. J., & Kloppenburg, M. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.131904 · Cited by 397 · see citing works

Prevalence and most common causes of disability among adults--United States, 2005.

(2009) · PubMed · Cited by 391 · see citing works

Effects of odors on pain perception: deciphering the roles of emotion and attention

Villemure, C., Slotnick, B. M., & Bushnell, C. M. (2003) · Pain · doi:10.1016/s0304-3959(03)00297-5 · Cited by 369 · see citing works

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

Sorge, R. E., Trang, T., Dorfman, R., Smith, S. B., Beggs, S., Ritchie, J., Austin, J., Zaykin, D. V., Meulen, H. V., Costigan, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2710 · Cited by 360 · see citing works

Osteoarthritis: national clinical guideline for care and management in adults

Birrell, F. N., Burke, M. V., Conaghan, P. G., Cumming, J., Dieppe, P. A., Dickson, J., Doherty, M., Dziedzic, K. S., Francis, R. M., Grant, R., et al. (2008) · Research Repository (Kingston University London) · Cited by 337 · see citing works

A longitudinal study to explain the pain‐depression link in older adults with osteoarthritis

HAWKER, G. A., Gignac, M. A. M., Badley, E. M., Davis, A. M., French, M., Li, Y., Perruccio, A. V., Power, J. D., Sale, J. E. M., & Lou, W. Y. W. (2010) · Arthritis Care & Research · doi:10.1002/acr.20298 · Cited by 328 · see citing works

Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study

Bajaj, P., Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Pain · doi:10.1016/s0304-3959(01)00300-1 · Cited by 317 · see citing works

Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis

Imamura, M., Imamura, S. T., Kaziyama, H. H. S., Targino, R. A., Hsing, W. T., de Souza, L. P. M., Cutait, M. M., Fregni, F., & Camanho, G. L. (2008) · Arthritis Care & Research · doi:10.1002/art.24120 · Cited by 314 · see citing works

Development and preliminary psychometric testing of a new OA pain measure – an OARSI/OMERACT initiative

HAWKER, G. A., Davis, A. M., French, M., Cibere, J., Jordan, J. M., MARCH, L. M., Suarez-Almazor, M. E., Katz, J. N., & Dieppe, P. A. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2007.12.015 · Cited by 314 · see citing works

The evolving role of obesity in knee osteoarthritis

Sowers, M. R., & Karvonen-Gutierrez, C. A. (2010) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32833b4682 · Cited by 305 · see citing works

Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial

Laslett, L. L., Aitken, D. A., Quinn, S. J., Boon, P., Ryan, E., Winzenberg, T. M., & Jones, G. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200970 · Cited by 299 · see citing works

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

Reginster, J., Badurski, J. E., Bellamy, N., Bensen, W., Chapurlat, R. D., Chevalier, X., Christiansen, C., Genant, H. K., Navarro, F., Nasonov, E. L., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202231 · Cited by 296 · see citing works

Different patterns of hyperalgesia induced by experimental inflammation in human skin

Kilo, S., Schmelz, M., Koltzenburg, M., & Handwerker, H. O. (1994) · Brain · doi:10.1093/brain/117.2.385 · Cited by 293 · see citing works

Determinants of pain severity in knee osteoarthritis: effect of demographic and psychosocial variables using 3 pain measures.

Creamer, P., Lethbridge‐Çejku, M., & Hochberg, M. C. (1999) · PubMed · Cited by 292 · see citing works

The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study

Maetzel, A., Li, L. C., Pencharz, J., TOMLINSON, G. A., & Bombardier, C. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.006031 · Cited by 274 · see citing works

A study of the gait characteristics of patients with chronic osteoarthritis of the knee

Al-Zahrani, K. S., & Bakheit, A. M. O. (2002) · Disability and Rehabilitation · doi:10.1080/09638280110087098 · Cited by 265 · see citing works

Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis

Richette, P., Poitou, C., Garnero, P., Vicaut, É., Bouillot, J., Lacorte, J., Basdevant, A., Clément, K., Bardin, T., & Chevalier, X. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.134015 · Cited by 254 · see citing works

Clinimetric properties of the AUSCAN Osteoarthritis Hand Index: an evaluation of reliability, validity and responsiveness

Bellamy, N., Campbell, J., Haraoui, B. P., Gerecz-Simon, E. M., Buchbinder, R., Hobby, K., & MacDermid, J. C. (2002) · Osteoarthritis and Cartilage · doi:10.1053/joca.2002.0838 · Cited by 252 · see citing works

Associations between pain, function, and radiographic features in osteoarthritis of the knee

Szebenyi, B., Hollander, A. P., Dieppe, P. A., Quilty, B., Duddy, J., Clarke, S., & Kirwan, J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21534 · Cited by 217 · see citing works

Arthritic pain is processed in brain areas concerned with emotions and fear

Kulkarni, B., Bentley, D. E., Elliott, R., Julyan, P. J., Boger, E. J., Watson, A., Boyle, Y., El‐Deredy, W., & Jones, A. K. P. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22460 · Cited by 214 · see citing works

Classification of chronic pain

Taxonomy, I. S. O. (1986) · Pain · Cited by 214 · see citing works

Direct medical costs unique to people with arthritis.

Gabriel, S. E., Crowson, C. S., Campion, M. E., & O’Fallon, W. M. (1997) · PubMed · Cited by 200 · see citing works

The nerve of osteoarthritis pain

Hochman, J. R., French, M., Bermingham, S. L., & HAWKER, G. A. (2010) · Arthritis Care & Research · doi:10.1002/acr.20142 · Cited by 197 · see citing works

Correlates of knee pain among US adults with and without radiographic knee osteoarthritis.

Davis, M. A., Ettinger, W. H., Neuhaus, J. M., Barclay, J. D., & Segal, M. R. (1992) · PubMed · Cited by 185 · see citing works

Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: A randomized controlled study

Somers, T. J., Blumenthal, J. A., Guilak, F., Kraus, V. B., Schmitt, D. O., Babyak, M. A., Craighead, L. W., Caldwell, D. S., Rice, J. R., McKee, D. C., et al. (2012) · Pain · doi:10.1016/j.pain.2012.02.023 · Cited by 178 · see citing works

Association of radiographic features of osteoarthritis of the knee with knee pain: Data from the baltimore longitudinal study of aging

Lethbridge‐Çejku, M., Scott, W. W., Reichle, R., Ettinger, W. H., Zonderman, A. B., Costa, P. T., Plato, C. C., Tobin, J. D., & Hochberg, M. C. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1790080311 · Cited by 174 · see citing works

Symptoms and radiographic osteoarthritis: not as discordant as they are made out to be?

Duncan, R., Peat, G., Thomas, E., Hay, E. M., McCall, I. W., & Croft, P. R. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.052548 · Cited by 173 · see citing works

Pain mechanisms in osteoarthritis of the knee: effect of intraarticular anesthetic.

Creamer, P., Hunt, M., & Dieppe, P. A. (1996) · PubMed · Cited by 167 · see citing works

Pain sensitivity and pain reactivity in osteoarthritis

Lee, Y., Lü, B., Bathon, J. M., Haythornthwaite, J. A., Smith, M. T., Page, G. G., & Edwards, R. R. (2010) · Arthritis Care & Research · doi:10.1002/acr.20373 · Cited by 166 · see citing works

Knee Pain Is the Malady—Not Osteoarthritis

Hadler, N. M. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-7-598 · Cited by 164 · see citing works

Epidemiologic associations of pain in osteoarthritis of the knee: Data from the national health and nutrition examination survey and the national health and nutrition examination-i epidemiologic follow-up survey

Hochberg, M. C., Lawrence, R. C., Everett, D. F., & Cornoni‐Huntley, J. C. (1989) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(89)90008-5 · Cited by 157 · see citing works

National Ambulatory Medical Care Survey: 2005 summary.

Cherry, D. K., Hing, E., Woodwell, D. A., et al. (2007) · PubMed · Cited by 157 · see citing works

Health‐related quality of life and health service use among older adults with osteoarthritis

Dominick, K. L., Ahern, F. M., Gold, C. H., & Heller, D. A. (2004) · Arthritis Care & Research · doi:10.1002/art.20390 · Cited by 153 · see citing works

Productivity costs and medical costs among working patients with knee osteoarthritis

Hermans, J., Koopmanschap, M. A., Bierma‐Zeinstra, S., van Linge, J. H., Verhaar, J. A. N., Reijman, M., & Burdorf, A. (2012) · Arthritis Care & Research · doi:10.1002/acr.21617 · Cited by 147 · see citing works

Pain Coping Skills Training for Patients with Elevated Pain Catastrophizing who are Scheduled for Knee Arthroplasty: A Quasi-Experimental Study

Riddle, D., Keefe, F., Nay, W. T., McKee, D., Attarian, D., & Jensen, M. (2011) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2011.01.003 · Cited by 147 · see citing works

Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: A cohort study

Riddle, D. L., & Stratford, P. W. (2012) · Arthritis Care & Research · doi:10.1002/acr.21692 · Cited by 146 · see citing works

Symptomatic Hand Osteoarthritis in the United States

Dillon, C. F., Hirsch, R., Rasch, E. K., & Gu, Q. (2006) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e31802ba28e · Cited by 142 · see citing works

Is emotional disturbance a precipitator or a consequence of chronic pain?

Gamsa, A. (1990) · Pain · doi:10.1016/0304-3959(90)91161-b · Cited by 134 · see citing works

Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial

Bliddal, H., Leeds, A., Stigsgaard, L., Astrup, A. V., & Christensen, R. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.142018 · Cited by 130 · see citing works

Relationship Between Social Desirability and Self-Report in Chronic Pain Patients

Deshields, T. L., Tait, R. C., Gfeller, J. D., & Chibnall, J. T. (1995) · Clinical Journal of Pain · doi:10.1097/00002508-199509000-00005 · Cited by 124 · see citing works

Negative affect, pain and disability in osteoarthritis patients: the mediating role of muscle weakness

Dekker, J., Tola, P., Aufdemkampe, G., & Winckers, M. (1993) · Behaviour Research and Therapy · doi:10.1016/0005-7967(93)90073-4 · Cited by 123 · see citing works

The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis

Valdes, A. M., Wilde, G. D., Doherty, S. A., Lories, R. J. U., Vaughn, F. L., Laslett, L. L., Maciewicz, R. A., Soni, A., Hart, D. J., Zhang, W., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.148122 · Cited by 123 · see citing works

Social environment moderates the association between catastrophizing and pain among persons with a spinal cord injury

Giardino, N. D., Jensen, M. P., Turner, J. A., Ehde, D. M., & Cardenas, D. D. (2003) · Pain · doi:10.1016/s0304-3959(03)00226-4 · Cited by 122 · see citing works

2004 National Hospital Discharge Survey.

DeFrances, C. J., & Podgornik, M. N. (2006) · PubMed · Cited by 119 · see citing works

Psychological factors and their relation to osteoarthritis pain

Wise, B. L., Niu, J., Zhang, Y., Wang, N., Jordan, J. M., Choy, E., & Hunter, D. J. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.11.016 · Cited by 114 · see citing works

Risk of sick leave and disability pension in working-age women and men with knee osteoarthritis

Hubertsson, J., Petersson, I. F., Thorstensson, C. A., & Englund, M. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201472 · Cited by 109 · see citing works

Factors associated with restricted mobility outside the home in community‐dwelling adults ages fifty years and older with knee pain: An example of use of the International Classification of Functioning to investigate participation restriction

Wilkie, R., Peat, G., Thomas, E., & Croft, P. R. (2007) · Arthritis Care & Research · doi:10.1002/art.23083 · Cited by 94 · see citing works

The Reliability and Vatidity of Pain Threshold Measurements in Osteoarthritis of the Knee

Wessel, J. (1995) · Scandinavian Journal of Rheumatology · doi:10.3109/03009749509100881 · Cited by 93 · see citing works

Daily pain variations among patients with hand, hip, and knee osteoarthritis

Allen, K. D., Coffman, C. J., Golightly, Y. M., Stechuchak, K. M., & Keefe, F. J. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.03.021 · Cited by 92 · see citing works

Racial differences in osteoarthritis pain and function: potential explanatory factors

Allen, K. D., Oddone, E. Z., Coffman, C. J., Keefe, F. J., Lindquist, J. H., & Bosworth, H. B. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.09.010 · Cited by 90 · see citing works

Is symptomatic knee osteoarthritis a risk factor for a trajectory of fast decline in gait speed? Results from a longitudinal cohort study

White, D. K., Niu, J., & Zhang, Y. (2012) · Arthritis Care & Research · doi:10.1002/acr.21816 · Cited by 85 · see citing works

Neural Mechanisms of Cutaneous Nociceptive Pain

Koltzenburg, M. (2000) · Clinical Journal of Pain · doi:10.1097/00002508-200009001-00004 · Cited by 82 · see citing works

A functional polymorphism in the catechol‐O‐methyltransferase gene is associated with osteoarthritis‐related pain

van Meurs, J. B. J., Uitterlinden, A. G., Stolk, L., Kerkhof, H. J. M., Albert Hofman, D., Pols, H. A. P., & Bierma‐Zeinstra, S. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24175 · Cited by 81 · see citing works

Expectations and anxiety as mediators of placebo effects in pain

Wager, T. D. (2005) · Pain · doi:10.1016/j.pain.2005.03.018 · Cited by 79 · see citing works

The Effect of Osteoarthritis of the Hip or Knee on Work Participation

BIELEMAN, H. J., Bierma‐Zeinstra, S., Oosterveld, F. G. J., Reneman, M. F., Verhagen, A. P., & Groothoff, J. W. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.101210 · Cited by 79 · see citing works

Osteoarthritis and Absenteeism Costs: Evidence From US National Survey Data

Kotlarz, H., Gunnarsson, C., Fang, H., & Rizzo, J. A. (2010) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e3181cf00aa · Cited by 78 · see citing works

The Natural History of Disability and Its Determinants in Adults with Lower Limb Musculoskeletal Pain

Ayis, S. A., & Dieppe, P. A. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.080455 · Cited by 77 · see citing works

Predicting the course of functional limitation among older adults with knee pain: do local signs, symptoms and radiographs add anything to general indicators?

Thomas, E., Peat, G., Mallen, C. D., Wood, L., Lacey, R., Duncan, R., & Croft, P. R. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.080945 · Cited by 70 · see citing works

Patterns of pharmacotherapy and health care utilization and costs prior to total hip or total knee replacement in patients with osteoarthritis

Berger, A., Bozic, K. J., Stacey, B. R., Edelsberg, J., Sadosky, A., & Oster, G. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30417 · Cited by 67 · see citing works

Metabolic factors in osteoarthritis: obese people do not walk on their hands

Yusuf, E. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3894 · Cited by 65 · see citing works

Relationship between symptoms and structural change in osteoarthritis. what are the important targets for osteoarthritis therapy?

Dieppe, P. A. (2004) · PubMed · Cited by 57 · see citing works

Lessons from Fibromyalgia: Abnormal Pain Sensitivity in Knee Osteoarthritis

Bradley, L. A., Kersh, B. C., DeBerry, J. J., DEUTSCH, G., Alarcón, G., & McLain, D. (2004) · Novartis Foundation symposium · doi:10.1002/0470867639.ch17 · Cited by 55 · see citing works

Inflammation-Mediated Hyperexcitability of Sensory Neurons

Gold, M. S., & Flake, N. (2005) · Neurosignals · doi:10.1159/000087653 · Cited by 54 · see citing works

A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype

Malfait, A., Seymour, A. B., Gao, F., Tortorella, M. D., Graverand‐Gastineau, M. H. L., Wood, L. S., Doherty, M., Doherty, S. A., Zhang, W., Arden, N. K., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200300 · Cited by 54 · see citing works

The National Hospital Bill: The Most Expensive Conditions by Payer, 2008

Wier, L. M., & Andrews, R. M. (2011) · Cited by 53 · see citing works

Outcome measures in placebo-controlled trials of osteoarthritis: responsiveness to treatment effects in the REPORT database

Dworkin, R. H., Peirce‐Sandner, S., Turk, D., McDermott, M., Gibofsky, A., Simon, L. S., Farrar, J. T., & Katz, N. P. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.02.020 · Cited by 52 · see citing works

Responsiveness of the OARSI–OMERACT osteoarthritis pain and function measures

Bond, M., Davis, A. M., Lohmander, S. L., & HAWKER, G. A. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.03.001 · Cited by 46 · see citing works

Role of the Na v 1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain

Valdes, A. M., Arden, N., Vaughn, F. L., Doherty, S. A., Leaverton, P. E., Zhang, W., Muir, K. R., Rampersaud, E., Dennison, E. M., Edwards, M. H., et al. (2010) · Arthritis Care & Research · doi:10.1002/acr.20375 · Cited by 44 · see citing works

Direct and Indirect Economic Costs Among Private-Sector Employees With Osteoarthritis

Berger, A., Hartrick, C. T., Edelsberg, J., Sadosky, A., & Oster, G. (2011) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e3182337620 · Cited by 39 · see citing works

Being careful: A grounded theory of emergent chronic knee problems

Maly, M. R., & Cott, C. A. (2009) · Arthritis Care & Research · doi:10.1002/art.24611 · Cited by 35 · see citing works

The need for standardization: A literature review of indirect costs of rheumatoid arthritis and osteoarthritis

Xie, F. (2008) · Arthritis Care & Research · doi:10.1002/art.23825 · Cited by 31 · see citing works

Recent approaches to understanding osteoarthritis pain.

Bradley, L. A. (2004) · PubMed · Cited by 20 · see citing works

Osteoarthritis

Hunter, D. J., & Bierma‐Zeinstra, S. (2019) · The Lancet · doi:10.1016/s0140-6736(19)30417-9 · Cited by 5,127 · see citing works

Osteoarthritis

Abramoff, B., & Caldera, F. E. (2020) · Medical Clinics of North America · doi:10.1016/j.mcna.2019.10.007 · Cited by 1,191 · see citing works

The burden of OA-health services and economics

Leifer, V. P., Katz, J. N., & Losina, E. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.05.007 · Cited by 739 · see citing works

Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis

Molnar, V., Matišić, V., Kodvanj, I., Bjelica, R., Jeleč, Ž., Hudetz, D., Rod, E., Čukelj, F., Vrdoljak, T., Vidović, D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179208 · Cited by 565 · see citing works

Animal models of osteoarthritis: classification, update, and measurement of outcomes

Kuyinu, E. L., Narayanan, G., Nair, L. S., & Laurencin, C. T. (2016) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-016-0346-5 · Cited by 587 · see citing works

Osteoarthritis

Tang, S., Zhang, C.-Q., Oo, W. M., Fu, K., Risberg, M., Bierma-Zeinstra, S., Neogi, T., Atukorala, I., Malfait, A., Ding, C., et al. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00594-6 · Cited by 28 · see citing works

Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis. A systematic review and meta-analysis

Øiestad, B. E., Juhl, C. B., Eitzen, I., & Thorlund, J. B. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.10.008 · Cited by 445 · see citing works

Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis.

Ayhan, E., Kesmezacar, H., & Akgun, I. (2014) · World Journal of Orthopaedics · doi:10.5312/wjo.v5.i3.351 · Cited by 445 · see citing works

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

Arra, M., Swarnkar, G., Ke, K., Otero, J. E., Ying, J., Duan, X., Maruyama, T., Rai, M. F., O’Keefe, R. J., Mbalaviele, G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17242-0 · Cited by 421 · see citing works

Osteoarthritis: the genesis of pain

Fu, K., Robbins, S. R., & McDougall, J. J. (2017) · Lara D. Veeken · doi:10.1093/rheumatology/kex419 · Cited by 331 · see citing works

Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

Wang, L., & He, C.-Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.967193 · Cited by 352 · see citing works

Evaluation and Treatment of Knee Pain

Duong, V., Oo, W. M., Ding, C., Culvenor, A. G., & Hunter, D. J. (2023) · JAMA · doi:10.1001/jama.2023.19675 · Cited by 344 · see citing works

OSTEOARTHRITIS JOINT PAIN: THE CYTOKINE CONNECTION

Miller, R. E., Miller, R. J., & Malfait, A. (2014) · Cytokine · doi:10.1016/j.cyto.2014.06.019 · Cited by 313 · see citing works

Fully automatic knee osteoarthritis severity grading using deep neural networks with a novel ordinal loss

Chen, P., Gao, L., Shi, X., Allen, K. D., & Yang, L. (2019) · Computerized Medical Imaging and Graphics · doi:10.1016/j.compmedimag.2019.06.002 · Cited by 309 · see citing works

Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double‐Blind Placebo‐Controlled Trial

Panahi, Y., Rahimnia, A., Sharafi, M., Alishiri, G., Saburi, A., & Sahebkar, A. (2014) · Phytotherapy Research · doi:10.1002/ptr.5174 · Cited by 310 · see citing works

Inflammation in osteoarthritis: the latest progress and ongoing challenges

Knights, A. J., Redding, S. J., & Maerz, T. (2022) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000923 · Cited by 306 · see citing works

Association of Joint Inflammation With Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study

Neogi, T., Guermazi, A., Roemer, F. W., Nevitt, M. C., Scholz, J., Arendt‐Nielsen, L., Woolf, C. J., Niu, J., Bradley, L. A., Quinn, E. K., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39488 · Cited by 274 · see citing works

The Burden of Osteoarthritis in Older Adults

HAWKER, G. A., & King, L. K. (2022) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2021.11.005 · Cited by 261 · see citing works

Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review

Kraus, V. B., Sprow, K., Powell, K. E., Büchner, D. M., Bloodgood, B., Piercy, K. L., George, S. M., & Kraus, W. E. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001944 · Cited by 257 · see citing works

Midterm Clinical Outcomes and MR Imaging Changes after Transcatheter Arterial Embolization as a Treatment for Mild to Moderate Radiographic Knee Osteoarthritis Resistant to Conservative Treatment

Okuno, Y., Korchi, A. M., Shinjo, T., Kato, S., & Kaneko, T. (2017) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2017.02.033 · Cited by 248 · see citing works

Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models

Eitner, A., Hofmann, G., & Schaible, H. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00349 · Cited by 229 · see citing works

Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy

Hu, S., Zhang, C., Ni, L., Huang, C., Chen, D., Shi, K., Jin, H., Zhang, K., Li, Y., Xie, L., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2680-0 · Cited by 236 · see citing works

Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial

Panahi, Y., Alishiri, G. H., Parvin, S., & Sahebkar, A. (2015) · Journal of Dietary Supplements · doi:10.3109/19390211.2015.1008611 · Cited by 229 · see citing works

The causal role of gut microbiota in development of osteoarthritis

Yu, X., Yang, Y.-Q., Cao, R.-R., Bo, L., & Lei, S.-F. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.08.003 · Cited by 216 · see citing works

The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date

Oo, W. M., Little, C. B., Duong, V., & Hunter, D. J. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s295224 · Cited by 212 · see citing works

Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis

Messier, S. P., Mihalko, S. L., Beavers, D. P., Nicklas, B. J., DeVita, P., Carr, J. J., Hunter, D. J., Lyles, M. F., Guermazi, A., Bennell, K. L., et al. (2021) · JAMA · doi:10.1001/jama.2021.0411 · Cited by 249 · see citing works

Total knee arthroplasty: improving outcomes with a multidisciplinary approach

Feng, J. E., Novikov, D., Anoushiravani, A. A., & Schwarzkopf, R. M. (2018) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s140550 · Cited by 178 · see citing works

Persistent postoperative pain after total knee arthroplasty: a prospective cohort study of potential risk factors

Rice, D., Kluger, M., McNair, P., Lewis, G., Somogyi, A., Borotkanics, R., Barratt, D., & Walker, M. (2018) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.05.070 · Cited by 152 · see citing works

Clinical, humanistic, and economic burden of osteoarthritis among noninstitutionalized adults in the United States.

Zhao, X., Shah, D., Gandhi, K., Wei, W.-H., Dwibedi, N., Webster, L., & Sambamoorthi, U. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.07.002 · Cited by 129 · see citing works

Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review

Dainese, P., Wyngaert, K. V., Mits, S. D., Wittoek, R., Ginckel, A. V., & Calders, P. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.12.003 · Cited by 167 · see citing works

Prognostic factors for progression of clinical osteoarthritis of the knee: a systematic review of observational studies

Bastick, A. N., Runhaar, J., Belo, J. N., & Bierma‐Zeinstra, S. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0670-x · Cited by 165 · see citing works

The Effect of an App for Day-to-Day Postoperative Care Education on Patients With Total Knee Replacement: Randomized Controlled Trial

Timmers, T., Janssen, L., van der Weegen, W., Das, D., Marijnissen, W.-J., Hannink, G., van der Zwaard, B. C., Plat, A., Thomassen, B., Swen, J.-W., et al. (2019) · JMIR mHealth and uHealth · doi:10.2196/15323 · Cited by 162 · see citing works

Osteoarthritis Year in Review 2016: biomarkers (biochemical markers)

Mobasheri, A., Bay‐Jensen, A., van Spil, W. E., Larkin, J. D., & Levesque, M. C. (2017) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.12.016 · Cited by 162 · see citing works

Is osteoarthritis one disease or a collection of many?

Deveza, L. A., & Loeser, R. F. (2017) · Lara D. Veeken · doi:10.1093/rheumatology/kex417 · Cited by 165 · see citing works

Non-human primates as a model for aging

Colman, R. J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.008 · Cited by 154 · see citing works

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

Parama, D., Boruah, M., Yachna, K., Rana, V., Banik, K., Harsha, C., Thakur, K. K., Dutta, U., Arya, A., Mao, X., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118182 · Cited by 155 · see citing works

A commentary on modelling osteoarthritis pain in small animals

Malfait, A., Little, C. B., & McDougall, J. J. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.06.003 · Cited by 154 · see citing works

Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets

Nanus, D. E., Badoume, A., Wijesinghe, S. N., Halsey, A. M., Hurley, P., Ahmed, Z., Botchu, R., Davis, E. T., Lindsay, M. A., & Jones, S. W. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103618 · Cited by 154 · see citing works

Early knee osteoarthritis

Favero, M., Ramonda, R., Goldring, M. B., Goldring, S. R., & Punzi, L. (2015) · RMD Open · doi:10.1136/rmdopen-2015-000062 · Cited by 153 · see citing works

Enhanced Pain Sensitivity Among Individuals With Symptomatic Knee Osteoarthritis: Potential Sex Differences in Central Sensitization

Bartley, E. J., King, C. D., Sibille, K. T., Cruz‐Almeida, Y., Riley, J. L., Glover, T. L., Goodin, B. R., Sotolongo, A. S., Herbert, M. S., Bulls, H. W., et al. (2015) · Arthritis Care & Research · doi:10.1002/acr.22712 · Cited by 151 · see citing works

Association between lower limb osteoarthritis and incidence of depressive symptoms: data from the osteoarthritis initiative

Veronese, N., Stubbs, B., Solmi, M., Smith, T. O., Noale, M., Cooper, C. C., & Maggi, S. (2016) · Age and Ageing · doi:10.1093/ageing/afw216 · Cited by 147 · see citing works

Phenotypes of osteoarthritis: current state and future implications.

Deveza, L. A., Nelson, A. E., & Loeser, R. F. (2019) · PubMed · Cited by 148 · see citing works

The role of obesity and adipose tissue dysfunction in osteoarthritis pain

Binvignat, M., Sellam, J., Berenbaum, F., & Felson, D. T. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01143-3 · Cited by 147 · see citing works

A mechanism‐based pain sensitivity index to characterize knee osteoarthritis patients with different disease stages and pain levels

Arendt‐Nielsen, L., Egsgaard, L. L., Petersen, K. K., Eskehave, T. N., Graven‐Nielsen, T., Hoeck, H. C., & Simonsen, O. H. (2014) · European Journal of Pain · doi:10.1002/ejp.651 · Cited by 144 · see citing works

Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety

Schmelz, M., Mantyh, P. W., Malfait, A., Farrar, J. T., Yaksh, T. L., Tive, L. A., & Viktrup, L. (2019) · Pain · doi:10.1097/j.pain.0000000000001625 · Cited by 146 · see citing works

Correlation between pain severity and levels of anxiety and depression in osteoarthritis patients: a systematic review and meta-analysis

Fonseca‐Rodrigues, D., Rodrigues, A. L., Martins, T., Pinto, J. M., Amorim, D., Almeida, A., & Pinto‐Ribeiro, F. (2021) · Rheumatology · doi:10.1093/rheumatology/keab512 · Cited by 141 · see citing works

Osteoarthritis Pain

Yu, H., Huang, T., Lu, W., Tong, L.-P., & Chen, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094642 · Cited by 117 · see citing works

Randomized, Double‐Blind, Placebo‐Controlled Trial of Intraarticular Trans ‐ Capsaicin for Pain Associated With Osteoarthritis of the Knee

Stevens, R. M., Ervin, J. E., Nezzer, J., Nieves, Y., Guedes, K., Burges, R., Hanson, P. D., & Campbell, J. N. (2019) · Arthritis & Rheumatology · doi:10.1002/art.40894 · Cited by 135 · see citing works

Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF‑α and IL‑6

Carvalho, A. M. D. S., Heimfarth, L., Pereira, E. W. M., Oliveira, F. S., de Menezes, I. R. A., Coutinho, H. D. M., Picot, L., Antoniolli, Â. R., Quintans, J. D. S. S., & Quintans‐Júnior, L. J. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b01116 · Cited by 129 · see citing works

The burden of osteoarthritis: Is it a rising problem?

Scheuing, W., Reginato, A. M., Deeb, M., & Kasman, S. A. (2023) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2023.101836 · Cited by 126 · see citing works

Polysomnographic characteristics in nonmalignant chronic pain populations: A review of controlled studies

Bjurstrom, M. F., & Irwin, M. R. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.03.004 · Cited by 123 · see citing works

Kaempferol Alleviates the Interleukin-1β-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-κB

Zhuang, Z., Ye, G., & Huang, B. (2017) · Medical Science Monitor · doi:10.12659/msm.902491 · Cited by 122 · see citing works

Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks

Francisco, V., Pérez, T., Pino, J., López, V., Franco‐Trepat, E., Alonso‐Pérez, A., González-Gay, M. Á., Mera, A., Lago, F., Gómez, R., et al. (2017) · Journal of Orthopaedic Research® · doi:10.1002/jor.23788 · Cited by 122 · see citing works

Peripheral Mechanisms Contributing to Osteoarthritis Pain

Syx, D., Tran, P. B., Miller, R. E., & Malfait, A. (2018) · Current Rheumatology Reports · doi:10.1007/s11926-018-0716-6 · Cited by 117 · see citing works

Diagnosing osteoarthritis from T2 maps using deep learning: an analysis of the entire Osteoarthritis Initiative baseline cohort

Pedoia, V., Lee, J., Norman, B., Link, T. M., & Majumdar, S. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.02.800 · Cited by 119 · see citing works

Internet Cognitive–Behavioral Therapy for Depression in Older Adults With Knee Osteoarthritis: A Randomized Controlled Trial

O'Moore, K., Newby, J., Andrews, G., Hunter, D. J., Bennell, K., Smith, J., & Williams, A. D. (2018) · Arthritis care & research · doi:10.1002/acr.23257 · Cited by 113 · see citing works

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis

Obeidat, A. M., Wood, M. J., Adamczyk, N. S., Ishihara, S., Li, J., Wang, L., Ren, D., Bennett, D. A., Miller, R. J., Malfait, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38241-x · Cited by 118 · see citing works

A clinical review of robotic navigation in total knee arthroplasty: historical systems to modern design

Siddiqi, A., Horan, T., Molloy, R. M., Bloomfield, M. R., Patel, P. D., & Piuzzi, N. S. (2021) · EFORT Open Reviews · doi:10.1302/2058-5241.6.200071 · Cited by 109 · see citing works

Dorsal Root Ganglia Macrophages Maintain Osteoarthritis Pain

Raoof, R., Gil, C. M., Lafeber, F. P. J. G., de Visser, H. M., Prado, J., Versteeg, S., Pascha, M. N., Heinemans, A. L. P., Adolfs, Y., Pasterkamp, R. J., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1787-20.2021 · Cited by 109 · see citing works

Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patterns

Berenbaum, F., & Walker, C. (2020) · Postgraduate medicine · doi:10.1080/00325481.2020.1730669 · Cited by 101 · see citing works

Colchicine mesoporous silica nanoparticles/hydrogel composite loaded cotton patches as a new encapsulator system for transdermal osteoarthritis management

Mohamed, A. L., Elmotasem, H., & Salama, A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.133 · Cited by 106 · see citing works

The metabolic characteristics and changes of chondrocytes in vivo and in vitro in osteoarthritis

Adam, M. S., Zhuang, H., Ren, X., Zhang, Y., & Zhou, P. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1393550 · Cited by 106 · see citing works

Damage‐Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons Through Toll‐like Receptor 4

Miller, R. E., Belmadani, A. A., Ishihara, S., Tran, P. B., Ren, D., Miller, R. J., & Malfait, A. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39291 · Cited by 104 · see citing works

Clinical descriptors for the recognition of central sensitization pain in patients with knee osteoarthritis

Lluch, E., Nijs, J., Courtney, C. A., Rebbeck, T. J., Wylde, V., Baert, I. A. C., Wideman, T. H., Howells, N., & Skou, S. T. (2017) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1358770 · Cited by 98 · see citing works

Osteoarthritis and ACL Reconstruction—Myths and Risks

Cheung, E. C., DiLallo, M., Feeley, B. T., & Lansdown, D. A. (2020) · Current Reviews in Musculoskeletal Medicine · doi:10.1007/s12178-019-09596-w · Cited by 100 · see citing works

Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment

Duan, L., Liang, Y.-J., Xu, X., Xiao, Y., & Wang, D.-P. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02290-0 · Cited by 97 · see citing works

Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner

Liao, Y., Ren, Y., Luo, X., Mirando, A. J., Long, J. T., Leinroth, A. P., Ji, R., & Hilton, M. J. (2022) · Science Signaling · doi:10.1126/scisignal.abn7082 · Cited by 102 · see citing works

Which one is more effective for the clinical treatment of chronic pain in knee osteoarthritis: radiofrequency neurotomy of the genicular nerves or intra‐articular injection?

Sarı, S., Aydin, O. N., Turan, Y., Özlülerden, P., Efe, U., & Ömürlü, İ. K. (2016) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12925 · Cited by 98 · see citing works

Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses

Chen, P., Huang, L., Ma, Y., Zhang, D., Zhang, X., Zhou, J., Ruan, A., & Wang, Q. (2019) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-019-1363-y · Cited by 98 · see citing works

Knee osteoarthritis and its association with mental health and health‐related quality of life: A nationwide cross‐sectional study

Park, H. C., Kim, H.-S., & Lee, Y. (2020) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13879 · Cited by 98 · see citing works

Addressing the growing burden of musculoskeletal diseases in the ageing US population: challenges and innovations

Nguyen, A. T., Lee, P., Rodriguez, E. K., Chahal, K., Freedman, B. R., & Nazarian, A. (2025) · The Lancet Healthy Longevity · doi:10.1016/j.lanhl.2025.100707 · Cited by 106 · see citing works

Validity of the central sensitization inventory with measures of sensitization in people with knee osteoarthritis

Gervais-Hupé, J., Pollice, J., Sadi, J., & Carlesso, L. C. (2018) · Clinical Rheumatology · doi:10.1007/s10067-018-4279-8 · Cited by 97 · see citing works

Nutraceutical Approach to Chronic Osteoarthritis: From Molecular Research to Clinical Evidence

Colletti, A., & Cicero, A. F. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312920 · Cited by 97 · see citing works

General practitioners’ views on managing knee osteoarthritis: a thematic analysis of factors influencing clinical practice guideline implementation in primary care

Egerton, T., Nelligan, R. K., Setchell, J., Atkins, L., & Bennell, K. L. (2018) · BMC Rheumatology · doi:10.1186/s41927-018-0037-4 · Cited by 91 · see citing works

Deep learning approach to predict pain progression in knee osteoarthritis

Guan, B., Liu, F., Mizaian, A. H., Demehri, S., Samsonov, A. A., Guermazi, A., & Kijowski, R. (2021) · Skeletal Radiology · doi:10.1007/s00256-021-03773-0 · Cited by 99 · see citing works

Long noncoding RNAs in osteoarthritis

Jiang, S., Lü, J., Deng, Z., Li, Y., & Lei, G. (2016) · Joint Bone Spine · doi:10.1016/j.jbspin.2016.09.006 · Cited by 95 · see citing works

Molecular Classification of Knee Osteoarthritis

Lv, Z., Yang, Y., Li, J.-W., Fei, Y.-X., Guo, H., Sun, Z.-Y., Lu, J., Xu, X.-Q., Jiang, Q., Ikegawa, S., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725568 · Cited by 93 · see citing works

Oxygen–Ozone Therapy for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials

Sconza, C., Respizzi, S., Virelli, L., Vandenbulcke, F., Iacono, F., Kon, E., & Matteo, B. D. (2019) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2019.05.043 · Cited by 94 · see citing works

A review on segmentation of knee articular cartilage: from conventional methods towards deep learning

Ebrahimkhani, S., Jaward, M. H., Cicuttini, F., Dharmaratne, A. T., Wang, Y., & de Herrera, A. G. S. (2020) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2020.101851 · Cited by 93 · see citing works

Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis

Noehren, B. W., Kosmac, K., Walton, R. G., Murach, K. A., Lyles, M. F., Loeser, R. F., Peterson, C. A., & Messier, S. P. (2018) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2018.05.011 · Cited by 93 · see citing works

The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis

Strath, L. J., Jones, C. D., George, A. P., Lukens, S. L., Morrison, S. A., Soleymani, T., Locher, J. L., Gower, B. A., & Sorge, R. E. (2019) · Pain Medicine · doi:10.1093/pm/pnz022 · Cited by 93 · see citing works

Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy

Gui, T., Luo, L., Chhay, B., Zhong, L., Wei, Y., Yao, L., Yu, W. H., Li, J., Nelson, C. L., Tsourkas, A., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121437 · Cited by 93 · see citing works

Artificial intelligence in diagnosis of knee osteoarthritis and prediction of arthroplasty outcomes: a review

Lee, L. S., Ping Keung, C. H. A. N., Wen, C., Fung, W. C., Cheung, A., Chan, V. W. K., Cheung, M. H., Fu, H., Yan, C. H., & Chiu, P. (2022) · Arthroplasty · doi:10.1186/s42836-022-00118-7 · Cited by 93 · see citing works

Pain Susceptibility Phenotypes in Those Free of Knee Pain With or at Risk of Knee Osteoarthritis: The Multicenter Osteoarthritis Study

Carlesso, L. C., Segal, N. A., Frey‐Law, L., Zhang, Y., Lu, N., Nevitt, M. C., Lewis, C. E., & Neogi, T. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40752 · Cited by 92 · see citing works

The Effects of Baduanjin Qigong on Postural Stability, Proprioception, and Symptoms of Patients With Knee Osteoarthritis: A Randomized Controlled Trial

Ye, J., Simpson, M. W., Liu, Y., Lin, W., Zhong, W., Cai, S., & Zou, L. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2019.00307 · Cited by 92 · see citing works

Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations

Weaver, K. R., Griffioen, M. A., Klinedinst, N. J., Galik, E. M., Duarte, A. C., Colloca, L., Resnick, B. M., Dorsey, S. G., & Renn, C. L. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2021.779068 · Cited by 92 · see citing works

Effect of 6-week retro or forward walking program on pain, functional disability, quadriceps muscle strength, and performance in individuals with knee osteoarthritis: a randomized controlled trial (retro-walking trial)

Alghadir, A. H., Anwer, S., Sarkar, B., Paul, A. K., & Anwar, D. (2019) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-019-2537-9 · Cited by 124 · see citing works

AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes

Trojian, T. H., Concoff, A. L., Joy, S. M., Hatzenbuehler, J. R., Saulsberry, W. J., & Coleman, C. I. (2016) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095683 · Cited by 90 · see citing works

The Influence of Adverse Childhood Experiences in Pain Management: Mechanisms, Processes, and Trauma-Informed Care

Tidmarsh, L. V., Harrison, R. N., Ravindran, D., Matthews, S. L., & Finlay, K. A. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.923866 · Cited by 89 · see citing works

Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis

Li, L., Li, Z., Li, Y., Hu, X., Zhang, Y., & Fan, P. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-3120-0 · Cited by 88 · see citing works

Platelet ‐ Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta‐analysis of 26 Randomized Controlled Trials

Tan, J., Chen, H., Zhao, L., & Huang, W. C. (2020) · Arthroscopy The Journal of Arthroscopic and Related Surgery · doi:10.1016/j.arthro.2020.07.011 · Cited by 88 · see citing works

Effects of Knee Osteoarthritis on Hip and Ankle Gait Mechanics

Ro, D. H., Lee, J., Lee, J., Park, J., Han, H., & Lee, M. C. (2019) · Advances in Orthopedics · doi:10.1155/2019/9757369 · Cited by 87 · see citing works

Ultrasonographic assessment of osteophytes in 127 patients with hand osteoarthritis: exploring reliability and associations with MRI, radiographs and clinical joint findings

Mathiessen, A., Haugen, I. K., Slatkowsky-Christensen, B., Bøyesen, P., Kvien, T. K., & Hammer, H. B. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-201195 · Cited by 85 · see citing works

The role of skeletal muscle in the pathophysiology and management of knee osteoarthritis

Krishnasamy, P., Hall, M., & Robbins, S. R. (2017) · Lara D. Veeken · doi:10.1093/rheumatology/kex515 · Cited by 85 · see citing works

Eccentric and Concentric Resistance Exercise Comparison for Knee Osteoarthritis

Vincent, K. R., Vasilopoulos, T., Montero, C., & Vincent, H. K. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002010 · Cited by 84 · see citing works

Knee osteoarthritis: Clinical connections to articular cartilage structure and function

Brody, L. T. (2014) · Physical Therapy in Sport · doi:10.1016/j.ptsp.2014.12.001 · Cited by 83 · see citing works

Intra-articular hyaluronic acid in the treatment of knee osteoarthritis: a Canadian evidence-based perspective

Bhandari, M., Bannuru, R. R., Babins, E. M., Martel‐Pelletier, J., Khan, M., Raynauld, J., Frankovich, R. J., McLeod, D., Devji, T., Phillips, M., et al. (2017) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x17729641 · Cited by 83 · see citing works

Efficacy and Safety of Massage for Osteoarthritis of the Knee: a Randomized Clinical Trial

Perlman, A. I., Fogerite, S. G., Glass, O., Bechard, E. M., Ali, A., Njike, V. Y., Pieper, C. F., Dmitrieva, N., Luciano, A., Rosenberger, L., et al. (2018) · Journal of General Internal Medicine · doi:10.1007/s11606-018-4763-5 · Cited by 82 · see citing works

Anti-inflammatory effect as a mechanism of effectiveness underlying the clinical benefits of pelotherapy in osteoarthritis patients: regulation of the altered inflammatory and stress feedback response

Ortega, E., Gálvez, I., Hinchado, M. D., Guerrero-Martín, J., Martín-Cordero, L., & Torres-Piles, S. T. (2017) · International Journal of Biometeorology · doi:10.1007/s00484-017-1361-x · Cited by 82 · see citing works

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

Pirosa, A., Gottardi, R., Alexander, P. G., & Tuan, R. S. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0847-8 · Cited by 81 · see citing works

Beyond joint damage: mechanistic insights into osteoarthritis pain

Rossettini, G., Cook, C. E., & Villafañe, J. H. (2026) · Pain Management · doi:10.1080/17581869.2026.2659824 · Cited by 2 · see citing works

Pain in osteoarthritis. Implications for optimal management

Trouvin, A., & Perrot, S. (2017) · Joint Bone Spine · doi:10.1016/j.jbspin.2017.08.002 · Cited by 100 · see citing works

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis

O’Neill, T. W., McCabe, P. S., & McBeth, J. (2018) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2018.10.007 · Cited by 422 · see citing works

Osteoarthritis and pain [Osteoartritte aǧri nedenleri]

(2007) · Dspace Repository (Marmara Üniversitesi)

The burden of osteoarthritis pain from patient’s perspective in the United States

Jackson, J., Iyer, R. G., Hubanova, P., Williams, N., Mellor, J., & Wei, W. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.02.614 · Cited by 2 · see citing works