Exogenous and endogenous glucocorticoids in rheumatic diseases

Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs

Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149 · see citing works

American college of rheumatology preliminary definition of improvement in rheumatoid arthritis

Felson, D. T., Anderson, J. J., Boers, M., Bombardier, C., Fürst, D. E., Goldsmith, C. H., Katz, L. M. G., Lightfoot, R. W., Paulus, H. E., Strand, V., et al. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380602 · Cited by 2,825 · see citing works

Neuroendocrine Regulation of Immunity

Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957 · see citing works

Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms.

Dhabhar, F. S., Miller, A. H., McEwen, B. S., & Spencer, R. L. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5511 · Cited by 730 · see citing works

11β-Hydroxysteroid Dehydrogenase

Stewart, P. M., & Krozowski, Z. S. (1997) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60646-9 · Cited by 716 · see citing works

Enhancing versus suppressive effects of stress hormones on skin immune function

Dhabhar, F. S., & McEwen, B. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.1059 · Cited by 672 · see citing works

Genomic and nongenomic effects of glucocorticoids

Stahn, C., & Buttgereit, F. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0898 · Cited by 594 · see citing works

Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

Schäcke, H., Schottelius, A., Döcke, W.-D., Strehlke, P., Jaroch, S., Schmees, N., Rehwinkel, H., Hennekes, H., & Asadullah, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0300372101 · Cited by 466 · see citing works

Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial

Buttgereit, F., Doering, G., Schaeffler, A., Witte, S., Sierakowski, S., Gromnica‐Ihle, E., Jeka, S., Krueger, K., Szechiński, J., & Alten, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60132-4 · Cited by 406 · see citing works

11β-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action

Draper, N., & Stewart, P. M. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06019 · Cited by 375 · see citing works

Glucocorticoids in the treatment of rheumatic diseases: An update on the mechanisms of action

Buttgereit, F., Straub, R. H., Wehling, M., & Burmester, G. R. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20583 · Cited by 359 · see citing works

Effects of glucocorticoids on radiological progression in rheumatoid arthritis

Kirwan, J., Bijlsma, J. W. J., Boers, M., & Shea, B. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006356 · Cited by 346 · see citing works

Complete remission of experimental arthritis by joint targeting of glucocorticoids with long‐circulating liposomes

Metselaar, J. M., Wauben, M. H. M., Wagenaar-Hilbers, J. P. A., Boerman, O. C., & Storm, G. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11140 · Cited by 303 · see citing works

Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man

Barber, A. E., Coyle, S. M., Marano, M. A., Fischer, E., Calvano, S. E., Fong, Y., Moldawer, L. L., & Lowry, S. F. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.5.1999 · Cited by 285 · see citing works

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1

Jeffrey, K. L., Brummer, T., Rolph, M. S., Liu, S. M., Callejas, N. A., Grumont, R. J., Gilliéron, C., Mackay, F., Grey, S. T., Camps, M., et al. (2006) · Nature Immunology · doi:10.1038/ni1310 · Cited by 270 · see citing works

Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor

Dayer, J., & Choy, E. (2009) · Rheumatology · doi:10.1093/rheumatology/kep329 · Cited by 270 · see citing works

Circadian rhythms in rheumatoid arthritis: Implications for pathophysiology and therapeutic management

Straub, R. H., & Cutolo, M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22368 · Cited by 262 · see citing works

Modulation of 11β-Hydroxysteroid Dehydrogenase Isozymes by Proinflammatory Cytokines in Osteoblasts: An Autocrine Switch from Glucocorticoid Inactivation to Activation

Cooper, M. S., Bujalska, I. J., Rabbitt, E. H., Walker, E. A., Bland, R., Sheppard, M. C., Hewison, M., & Stewart, P. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.6.1037 · Cited by 227 · see citing works

The Role of Interleukin-6 in Nociception and Pain

Jongh, R. F. D., Vissers, K. C. P., Meert, T. F., Booij, L. H. D. J., Deyne, C. S. D., & Heylen, R. J. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000055362.56604.78 · Cited by 226 · see citing works

Selective glucocorticoid receptor agonists (SEGRAs): Novel ligands with an improved therapeutic index

Schäcke, H., Berger, M., Rehwinkel, H., & Asadullah, K. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.014 · Cited by 223 · see citing works

Optimised glucocorticoid therapy: the sharpening of an old spear

Buttgereit, F., Burmester, G. R., & Lipworth, B. J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17989-6 · Cited by 221 · see citing works

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

Lim, H., Müller, N., Herold, M. J., van den Brandt, J., & Reichardt, H. M. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02611.x · Cited by 218 · see citing works

Circadian rhythm of serum interleukin-6 in rheumatoid arthritis.

Arvidson, N. G., Guðbjörnsson, B., Elfman, L., Rydén, A. C., Tötterman, T. H., & Hällgren, R. (1994) · Annals of the Rheumatic Diseases · doi:10.1136/ard.53.8.521 · Cited by 201 · see citing works

Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice

van der Goes, M. C., Jacobs, J. W. G., Boers, M., Andrews, T., Blom-Bakkers, M. A. M., Buttgereit, F., Caeyers, N., Cutolo, M., da Silva, J. A. P., Guillevin, L., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.124958 · Cited by 194 · see citing works

Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn

Löwenberg, M., Tuynman, J. B., Bilderbeek, J., Gaber, T., Buttgereit, F., van Deventer, S. J. H., Peppelenbosch, M. P., & Hommes, D. W. (2005) · Blood · doi:10.1182/blood-2004-12-4790 · Cited by 170 · see citing works

How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis

Straub, R. H., Dhabhar, F. S., Bijlsma, J. W. J., & Cutolo, M. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20747 · Cited by 168 · see citing works

Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice

Kleiman, A., & Tuckermann, J. P. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.009 · Cited by 165 · see citing works

Glucocorticoid Physiology, Pharmacology and Stress

Munck, A. U., & Guyre, P. M. (1986) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5101-6_6 · Cited by 158 · see citing works

GITR: A Modulator of Immune Response and Inflammation

Nocentini, G., & Riccardi, C. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-89520-8_11 · Cited by 158 · see citing works

Glucocorticoids cause rapid dissociation of a T‐cell‐receptor‐associated protein complex containing LCK and FYN

Löwenberg, M., Verhaar, A. P., Bilderbeek, J., van Marle, J., Buttgereit, F., Peppelenbosch, M. P., van Deventer, S. J. H., & Hommes, D. W. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400775 · Cited by 157 · see citing works

Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters

Kalajzic, Z., Liu, P., Kalajzić, I., Du, Z., Braut, A., Mina, M., CANALIS, E. M., & Rowe, D. W. (2002) · Bone · doi:10.1016/s8756-3282(02)00912-2 · Cited by 144 · see citing works

Circadian rhythms in RA

Cutolo, M., SERIOLO, B., Craviotto, C., Pizzorni, C., & Sulli, A. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.7.593 · Cited by 135 · see citing works

Similar effects of disease‐modifying antirheumatic drugs, glucocorticoids, and biologic agents on radiographic progression in rheumatoid arthritis: Meta‐analysis of 70 randomized placebo‐controlled or drug‐controlled studies, including 112 comparisons

Graudal, N. A., & Jűrgens, G. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27592 · Cited by 135 · see citing works

Bidirectional effects of stress and glucocorticoid hormones on immune function : possible explanations for paradoxical observations

Dhabhar, F. S. (2001) · Medical Entomology and Zoology · Cited by 131 · see citing works

Overnight variations in cortisol, interleukin 6, tumour necrosis factor α and other cytokines in people with rheumatoid arthritis

Perry, M. G., Kirwan, J., Jessop, D. S., & Hunt, L. P. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.086561 · Cited by 130 · see citing works

Transgenic Expression of 11β-Hydroxysteroid Dehydrogenase Type 2 in Osteoblasts Reveals an Anabolic Role for Endogenous Glucocorticoids in Bone

Sher, L. B., Woitge, H. W., Adams, D. J., Gronowicz, G., Krozowski, Z. S., Harrison, J. R., & Kream, B. E. (2003) · Endocrinology · doi:10.1210/en.2003-0655 · Cited by 124 · see citing works

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

Schäcke, H., Zollner, T., Döcke, W., Rehwinkel, H., Jaroch, S., Skuballa, W., Neuhaus, R., May, E., Zügel, U., & Asadullah, K. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00238.x · Cited by 121 · see citing works

Local and systemic glucocorticoid metabolism in inflammatory arthritis

Hardy, R., Rabbitt, E. H., Filer, A. D., Emery, P., Hewison, M., Stewart, P. M., Gittoes, N. J. L., Buckley, C. D., Raza, K., & Cooper, M. S. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.090662 · Cited by 118 · see citing works

Altered circadian rhythms in rheumatoid arthritis patients play a role in the disease's symptoms

Cutolo, M., Villaggio, B., Otsa, K., Aakre, O., Sulli, A., & SERIOLO, B. (2005) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.04.019 · Cited by 117 · see citing works

Glucocorticoids accelerate anti-T cell receptor-induced T cell growth

Wiegers, G. J., Labeur, M. S., Stec, I. E. M., Klinkert, W. E. F., Holsboer, F., & Reul, J. M. H. M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.4.1893 · Cited by 113 · see citing works

Targeting pathophysiological rhythms: prednisone chronotherapy shows sustained efficacy in rheumatoid arthritis

Buttgereit, F., Doering, G., Schaeffler, A., Witte, S., Sierakowski, S., Gromnica‐Ihle, E., Jeka, S., Krueger, K., Szechiński, J., & Alten, R. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.126888 · Cited by 111 · see citing works

Clinical aspects of rheumatoid arthritis

Khurana, R., & Berney, S. M. (2005) · Pathophysiology · doi:10.1016/j.pathophys.2005.07.009 · Cited by 100 · see citing works

Hypothalamus-Pituitary-Adrenal Axis Function in Patients with Rheumatoid Arthritis Treated with Nighttime-Release Prednisone

Alten, R., DÖRING, G., Cutolo, M., Gromnica‐Ihle, E., WITTE, S., Straub, R. H., & Buttgereit, F. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100051 · Cited by 93 · see citing works

Circadian Rhythms and Arthritis

Cutolo, M., & Masi, A. T. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.09.005 · Cited by 80 · see citing works

Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies

Lee, H., Zahra, D., Vogelzang, A., Newton, R. A., Thatcher, J., Quan, A., So, T., Zwirner, J., Köentgen, F., Padkjær, S. B., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1248 · Cited by 66 · see citing works

Morning stiffness and its influence on early retirement in patients with recent onset rheumatoid arthritis

Westhoff, G., Buttgereit, F., Gromnica-Ihle, E., & Zink, A. (2008) · Rheumatology · doi:10.1093/rheumatology/ken137 · Cited by 66 · see citing works

Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment

Rauchhaus, U., Schwaiger, F., & Panzner, S. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2889 · Cited by 63 · see citing works

Differential mechanism of NF‐κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

Gossye, V., Elewaut, D. S., Bougarne, N., Bracke, D., Calenbergh, S. V., Haegeman, G., & Bosscher, K. D. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24963 · Cited by 60 · see citing works

Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum–induced arthritis in vivo

Buttgereit, F., Zhou, H., Kalak, R., Gaber, T., Spies, C. M., Huscher, D., Straub, R. H., Modzelewski, J. R. K., Dunstan, C. R., & Seibel, M. J. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24619 · Cited by 54 · see citing works

Glucocorticoid-mediated Inhibition of Lck Modulates the Pattern of T Cell Receptor-induced Calcium Signals by Down-regulating Inositol 1,4,5-Trisphosphate Receptors

Harr, M. W., Rong, Y., Bootman, M. D., Roderick, H. L., & Distelhorst, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005579 · Cited by 54 · see citing works

Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug

Zimmermann, G. R., Avery, W., Finelli, A. L., Farwell, M., Fraser, C. C., & Borisy, A. A. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2602 · Cited by 54 · see citing works

Dose- and time-dependent activation of rat alveolar macrophages by glucocorticoids

Broug-Holub, E., & Kraal, G. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.29733.x · Cited by 52 · see citing works

Psychoneuroimmunology

Felten, D. L., & Maida, M. E. (2002) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00244-8 · Cited by 49 · see citing works

Corticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes.

Cooper, D. A., Duckett, M., Hansen, P., et al. (1979) · PubMed · Cited by 46 · see citing works

Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus

Du, J., Li, M., Zhang, D., Zhu, X., Zhang, W., Gu, W., Feng, Y.-L., Zhai, X., & Ling, C. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2763 · Cited by 44 · see citing works

Targeted delivery of liposomal dexamethasone phosphate to the spleen provides a persistent therapeutic effect in rat antigen-induced arthritis

Rauchhaus, U., Kinne, R. W., Pohlers, D., Wiegand, S., Wolfert, A., Gajda, M. R., Bräuer, R., & Panzner, S. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.108985 · Cited by 35 · see citing works

Glucocorticoids Regulate TCR-Induced Elevation of CD4: Functional Implications

Wiegers, G. J., Stec, I. E. M., Klinkert, W. E. F., & Reul, J. M. H. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6213 · Cited by 34 · see citing works

Sensitization of rat alveolar macrophages to enhanced TNF-α release by in vivo treatment with dexamethasone

Renz, H., Henke, A., Hofmann, P., et al. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90242-h · Cited by 23 · see citing works

Influence of a Co-stimulation of Human Leucocytes with an Escherichia coli Preparation and Fixed Immunoglobulins on Cytokine Release in the Presence of Hydrocortisone

Gebauer, F., Ottendorfer, D., Kunze, R., et al. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300023 · Cited by 6 · see citing works

Untitled work

Lawrence (1998) · doi:10.1002/1529-0131(199805)41:5

The brain and immune system prompt energy shortage in chronic inflammation and ageing

Straub, R. H. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.172 · Cited by 192 · see citing works

Interaction of the endocrine system with inflammation: a function of energy and volume regulation

Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works

Osteocalcin: an osteoblast-derived polypeptide hormone that modulates whole body energy metabolism

Brennan-Speranza, T. C., & Conigrave, A. D. (2015) · Calcified Tissue International · doi:10.1007/s00223-014-9931-y · Cited by 71 · see citing works

Immediate-release granule formulation of hydrocortisone, Alkindi®, for treatment of paediatric adrenal insufficiency (Infacort development programme)

Porter, J., Withe, M., & Ross, R. J. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1455496 · Cited by 26 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

Interleucinas na encefalopatia hipóxico-isquêmica

Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14 · see citing works