The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
β‐glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice
Abstract
Objective: The spondylarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, and arthritis associated with inflammatory bowel disease, cause chronic inflammation of the large peripheral and axial joints, eyes, skin, ileum, and colon. Genetic studies reveal common candidate genes for AS, PsA, and Crohn's disease, including IL23R, IL12B, STAT3, and CARD9, all of which are associated with interleukin‐23 (IL‐23) signaling downstream of the dectin 1 β‐glucan receptor. In autoimmune‐prone SKG mice with mutated ZAP‐70, which attenuates T cell receptor signaling and increases the autoreactivity of T cells in the peripheral repertoire, IL‐17–dependent inflammatory arthritis developed after dectin 1–mediated fungal infection. This study was undertaken to determine whether SKG mice injected with 1,3‐β‐glucan (curdlan) develop evidence of SpA, and the relationship of innate and adaptive autoimmunity to this process. Methods: SKG mice and control BALB/c mice were injected once with curdlan or mannan. Arthritis was scored weekly, and organs were assessed for pathologic features. Anti–IL‐23 monoclonal antibodies were injected into curdlan‐treated SKG mice. CD4+ T cells were transferred from curdlan‐treated mice to SCID mice, and sera were analyzed for autoantibodies. Results: After systemic injection of curdlan, SKG mice developed enthesitis, wrist, ankle, and sacroiliac joint arthritis, dactylitis, plantar fasciitis, vertebral inflammation, ileitis resembling Crohn's disease, and unilateral uveitis. Mannan triggered spondylitis and arthritis. Arthritis and spondylitis were T cell– and IL‐23–dependent and were transferable to SCID recipients with CD4+ T cells. SpA was associated with collagen‐ and proteoglycan‐specific autoantibodies. Conclusion: Our findings indicate that the SKG ZAP‐70 W163C mutation predisposes BALB/c mice to SpA, resulting from innate and adaptive autoimmunity, after systemic β‐glucan or mannan exposure.
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Cites
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Cited by
The Australo-Anglo-American Spondyloarthritis Consortium (TASC), Evans, D. M., the Wellcome Trust Case Control Consortium 2 (WTCCC2), Spondyloarthritis Research Consortium of Canada (SPARCC), Spencer, C. C. A., Pointon, J. J., Su, Z., Harvey, D., Kochan, G., Oppermann, U., et al. (2011) · Nature Genetics · doi:10.1038/ng.873 · Cited by 893
Self-citationMaeda, Y., Kurakawa, T., Umemoto, E., Motooka, D., Ito, Y., Gotoh, K., Hirota, K., Matsushita, M., Furuta, Y., Narazaki, M., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39783 · Cited by 686
The IL-23-IL-17 axis in inflammatory arthritis
Lubberts, E. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.53 · Cited by 442
The Gut Microbiota in Immune-Mediated Inflammatory Diseases
Forbes, J. D., Van Domselaar, G., & Bernstein, C. N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01081 · Cited by 429
Ankylosing spondylitis: an autoimmune or autoinflammatory disease?
Mauro, D., Thomas, R., Guggino, G., Lories, R., Brown, M. A., & Ciccia, F. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00625-y · Cited by 353
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Metadata
- Authors
- Ruutu, M., Thomas, G., Steck, R., Degli‐Esposti, M. A., Zinkernagel, M. S., Alexander, K., Velasco, J., Strutton, G., Tran, A., Benham, H., Rehaume, L., Wilson, R. J., Kikly, K., Davies, J., Pettit, A. R., Brown, M. A., McGuckin, M. A., & Thomas, R.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2012-06-26
- Volume
- 64
- Issue
- 7
- Pages
- 2211-2222
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2078428843
- Cited by
- 262
- References
- 42
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ruutu, M., Thomas, G., Steck, R., Degli‐Esposti, M. A., Zinkernagel, M. S., Alexander, K., Velasco, J., Strutton, G., Tran, A., Benham, H., Rehaume, L., Wilson, R. J., Kikly, K., Davies, J., Pettit, A. R., Brown, M. A., McGuckin, M. A., & Thomas, R. (2012). β‐glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis & Rheumatism. https://doi.org/10.1002/art.34423
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