The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
Open accessAbstract
To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P < 10−800), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 × 10−19) and 21q22 (rs2242944; P = 8.3 × 10−20), as well as in the genes ANTXR2 (rs4333130; P = 9.3 × 10−8) and IL1R2 (rs2310173; P = 4.8 × 10−7). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 × 10−14) and ERAP1 (rs27434; P = 5.3 × 10−12). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility.
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Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Wellcome Trust Case Control Consortium, & The Australo-Anglo-American Spondylitis Consortium (TASC) (2007) · Nature Genetics · doi:10.1038/ng.2007.17 · Cited by 1,374
Long-Range LD Can Confound Genome Scans in Admixed Populations
Price, A. L., Weale, M. E., Patterson, N., Myers, S. R., Need, A. C., Shianna, K. V., Ge, D., Rotter, J. I., Torres, E., Taylor, K. D., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.06.005 · Cited by 443
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Lubberts, E. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.53 · Cited by 442
Metadata
- Authors
- The Australo-Anglo-American Spondyloarthritis Consortium (TASC)
- Venue
- Nature Genetics
- Published
- 2010-01-10
- Volume
- 42
- Issue
- 2
- Pages
- 123-127
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2118434625
- Cited by
- 668
- References
- 3
- FWCI
- 40.55
- Type
- journal article
- Language
- en
- Open access
- green
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