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Cited by 69Folate and B Vitamins ResearchSpinal Dysraphism and MalformationsPharmacological Effects and Toxicity Studies

Folic acid supplementation and neural tube defect recurrence prevention

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Grosse, Scott D., Collins, Julianne S.·2007·Birth Defects Research Part A: Clinical and Molecular Teratology
DOI 10.1002/bdra.20394
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Abstract

BACKGROUND: It is well established that women who have had a pregnancy affected by a neural tube defect (NTD) have an elevated risk of a subsequent NTD‐affected pregnancy and that a high dose (4 mg/day) of folic acid taken around the time of conception prevents most recurrences of NTDs. METHODS: We reviewed the literature to identify studies that quantify the reduction in risk if women with a prior‐NTD affected pregnancy consistently take folic acid before and during a subsequent pregnancy and the effectiveness of NTD recurrence prevention programs in increasing the percentage of women who consistently consume folic acid supplements. RESULTS: A meta‐analysis of randomized trials of folic acid for the prevention of recurrent NTDs indicates a 69% reduction in recurrence risk if analyzed on an intention‐to‐treat basis and an 87% reduction among those women who took supplements prior to the beginning of pregnancy. Observational studies report reductions in recurrence risk of 85% to 100% among women taking folic acid prior to subsequent pregnancies. The percentage of women who take folic acid prior to a subsequent pregnancy has been reported to vary from 33% to 85%, varying with the demographic background and the intensity of folic acid counseling efforts. CONCLUSIONS: Targeted folic acid information and counseling provided to women with an NTD‐affected pregnancy has been demonstrated to substantially reduce the risk of recurrent NTDs and is feasible to implement on a public health basis. Birth Defects Research (Part A) 79:737–742, 2007. © 2007 Wiley‐Liss, Inc.

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  • In a large UK prospective cohort of non-pregnant women, less than 6% of those who became pregnant reported daily folic acid supplementation of at least 0.4 mg per day.

    “in a large U.K. prospective cohort study of non-pregnant women, less than 6% of women who became pregnant during the observation period reported daily folic acid supplementation of ≥0.4mg/day [45].”

    From Complementary and alternative medicine therapies for perinatal depression (2014) · cites this paper as [45]

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Authors
Grosse, S. D., & Collins, J. S.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • Greenwood Genetic Center (US)
Corresponding author
Grosse, Scott D.
ORCID
Grosse, Scott D.
Venue
Birth Defects Research Part A: Clinical and Molecular Teratology
Publisher
Wiley
Published
2007-11
Volume
79
Issue
11
Pages
737-742
ISSN
  • 1542-0752 (ISSN-L)
  • 1542-0760
DOI
10.1002/bdra.20394
OpenAlex
W2106041012
Cited by
69
References
35
Citations by year
2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 5
FWCI
3.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Birth Defects Research Part A Clinical and Molecular Teratology (publishedVersion, public-domain)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Spinal Dysraphism and Malformations
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Keywords
folic acid supplementation, neural tube defects, recurrence prevention, pregnancy, preconception supplementation, prenatal counseling, public health programs, birth defects prevention
MeSH terms
Female, Folic Acid, Humans, Health Knowledge, Attitudes, Practice, Neural Tube Defects, Pregnancy, Prenatal Care, Recurrence, Randomized Controlled Trials as Topic, Dietary Supplements

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