The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Insights into metabolic mechanisms underlying folate‐responsive neural tube defects: A minireview
Open accessAbstract
Neural tube defects (NTDs), including anencephaly and spina bifida, arise from the failure of neurulation during early embryonic development. Neural tube defects are common birth defects with a heterogenous and multifactorial etiology with interacting genetic and environmental risk factors. Although the mechanisms resulting in failure of neural tube closure are unknown, up to 70% of NTDs can be prevented by maternal folic acid supplementation. However, the metabolic mechanisms underlying the association between folic acid and NTD pathogenesis have not been identified. This review summarizes our current understanding of the mechanisms by which impairments in folate metabolism might ultimately lead to failure of neural tube closure, with an emphasis on untangling the relative contributions of nutritional deficiency and genetic risk factors to NTD pathogenesis. Birth Defects Research (Part A) 2009. © 2009 Wiley‐Liss, Inc.
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Citations
Cites
Neural tube defects and folate: case far from closed
Blom, H. J., Shaw, G. M., den Heijer, M., & Finnell, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1986 · Cited by 562
Telomere shortening in mTR−/− embryos is associated with failure to close the neural tube
Herrera, E., Samper, E., & Blasco, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1172 · Cited by 147
Stover, P., & Schirch, V. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77290-6 · Cited by 139
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Cited by
One-Carbon Metabolism in Health and Disease
Ducker, G. S., & Rabinowitz, J. D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.009 · Cited by 2,239
Epidemiologic and genetic aspects of spina bifida and other neural tube defects
Au, K. S., Ashley‐Koch, A., & Northrup, H. (2010) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.93 · Cited by 344
Metabolic signatures of cancer cells and stem cells
Intlekofer, A. M., & Finley, L. W. S. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0032-0 · Cited by 322
Genetics of human neural tube defects
Greene, N. D. E., Stanier, P., & Copp, A. J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp347 · Cited by 310
One-Carbon Metabolism–Genome Interactions in Folate-Associated Pathologies ,
Stover, P. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.113670 · Cited by 276
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Metadata
- Authors
- Beaudin, A. E., & Stover, P. J.
- Venue
- Birth Defects Research Part A: Clinical and Molecular Teratology
- Publisher
- Wiley
- Published
- 2009-01-29
- Volume
- 85
- Issue
- 4
- Pages
- 274-284
- ISSN
- 1542-0752 (ISSN-L)
- 1542-0760
- OpenAlex
- W1996451222
- Cited by
- 161
- References
- 3
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Beaudin, A. E., & Stover, P. J. (2009). Insights into metabolic mechanisms underlying folate‐responsive neural tube defects: A minireview. Birth Defects Research Part A: Clinical and Molecular Teratology. https://doi.org/10.1002/bdra.20553
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