One-Carbon Metabolism in Health and Disease

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154 · see citing works

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,238 · see citing works

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945 · see citing works

Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683 · see citing works

Serine, glycine and one-carbon units: cancer metabolism in full circle

Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,669 · see citing works

Methionine metabolism in mammals

Finkelstein, J. D. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90070-2 · Cited by 1,495 · see citing works

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403 · see citing works

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388 · see citing works

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

Kansanen, E., Kuosmanen, S. M., Leinonen, H., & Levonen, A.-L. (2013) · Redox Biology · doi:10.1016/j.redox.2012.10.001 · Cited by 1,313 · see citing works

Oxidative stress inhibits distant metastasis by human melanoma cells

Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15726 · Cited by 1,269 · see citing works

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

Sullivan, L. B., Gui, D. Y., Hosios, A. M., Bush, L. N., Freinkman, E., & Vander Heiden, M. G. (2015) · Cell · doi:10.1016/j.cell.2015.07.017 · Cited by 1,173 · see citing works

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.890 · Cited by 1,120 · see citing works

Quantitative flux analysis reveals folate-dependent NADPH production

Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., & Rabinowitz, J. D. (2014) · Nature · doi:10.1038/nature13236 · Cited by 1,114 · see citing works

Serine and glycine metabolism in cancer

Amelio, I., Cutruzzolà, F., Antonov, A., Agostini, M., & Melino, G. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.004 · Cited by 1,056 · see citing works

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature · doi:10.1038/nature11743 · Cited by 1,007 · see citing works

Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2211 · Cited by 893 · see citing works

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., & Manning, B. D. (2016) · Science · doi:10.1126/science.aad0489 · Cited by 795 · see citing works

Amino Acid Metabolism in Man

Felig, P. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.004441 · Cited by 789 · see citing works

NRF2 regulates serine biosynthesis in non–small cell lung cancer

DeNicola, G. M., Chen, P.-H., Mullarky, E., Sudderth, J., Hu, Z., Wu, D., Tang, H., Xie, Y., Asara, J. M., Huffman, K. E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3421 · Cited by 747 · see citing works

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

Mentch, S. J., Mehrmohamadi, M., Huang, L., Liu, X., Gupta, D., Mattocks, D. A. L., Padilla, P. G., Ables, G. P., Bamman, M. M., Thalacker‐Mercer, A. E., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.024 · Cited by 706 · see citing works

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

Tibbetts, A. S., & Appling, D. R. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104810 · Cited by 692 · cited 3× · see citing works

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis

Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.050 · Cited by 660 · see citing works

Spina bifida

Copp, A. J., Adzick, N. S., Chitty, L. S., Fletcher, J. M., Holmbeck, G. N., & Shaw, G. M. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.7 · Cited by 657 · see citing works

Influence of Threonine Metabolism on <i>S</i> -Adenosylmethionine and Histone Methylation

Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., et al. (2013) · Science · doi:10.1126/science.1226603 · Cited by 638 · see citing works

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

Nilsson, R., Jain, M., Madhusudhan, N., Sheppard, N. G., Strittmatter, L., Kampf, C., Huang, J., Asplund, A., & Mootha, V. K. (2014) · Nature Communications · doi:10.1038/ncomms4128 · Cited by 607 · see citing works

Reversible compartmentalization of de novo purine biosynthetic complexes in living cells

An, S., Kumar, R., Sheets, E. D., & Benkovic, S. J. (2008) · Science · doi:10.1126/science.1152241 · Cited by 585 · cited 1× · see citing works

Choline and betaine in health and disease

Ueland, P. M. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9088-4 · Cited by 577 · see citing works

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells

Labuschagne, C. F., van den Broek, N. J. F., Mackay, G. M., Vousden, K. H., & Maddocks, O. D. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.045 · Cited by 576 · see citing works

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

Lewis, C. A., Parker, S. J., Fiske, B. P., McCloskey, D., Gui, D. Y., Green, C. R., Vokes, N. I., Feist, A. M., Vander Heiden, M. G., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.008 · Cited by 562 · see citing works

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Pacold, M. E., Brimacombe, K. R., Chan, S. H., Rohde, J. M., Lewis, C. A., Swier, L. J. Y. M., Possemato, R., Chen, W. W., Sullivan, L. B., Fiske, B. P., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2070 · Cited by 553 · see citing works

Homocysteine, B Vitamins, and Cognitive Impairment

Smith, A. D., & Refsum, H. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050947 · Cited by 524 · see citing works

Complementation of mitochondrial electron transport chain by manipulation of the NAD ⁺ /NADH ratio

Titov, D. V., Cracan, V., Goodman, R. P., Peng, J., Grabarek, Z., & Mootha, V. K. (2016) · Science · doi:10.1126/science.aad4017 · Cited by 518 · see citing works

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Ye, J., Fan, J., Venneti, S., Wan, Y.-W., Pawel, B. R., Zhang, J., Finley, L. W. S., Lu, C., Lindsten, T., Cross, J. R., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0250 · Cited by 452 · see citing works

Epidemiologic Studies of Folate and Colorectal Neoplasia: a Review

Giovannucci, E. L. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2350s · Cited by 451 · see citing works

Homocysteine and stroke: evidence on a causal link from mendelian randomisation

Casas, J. P., Bautista, L. E., Smeeth, L. L., Sharma, P. K., & Hingorani, A. D. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17742-3 · Cited by 442 · see citing works

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

Maddocks, O. D. K., Labuschagne, C. F., Adams, P. D., & Vousden, K. H. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.014 · Cited by 440 · see citing works

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

Bao, X. R., Ong, S., Goldberger, O., Peng, J., Sharma, R., Thompson, D. A., Vafai, S. B., Cox, A. G., Marutani, E., Ichinose, F., et al. (2016) · eLife · doi:10.7554/elife.10575 · Cited by 439 · see citing works

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.007 · Cited by 429 · see citing works

Effect of Folic Acid Supplementation on Risk of Cardiovascular Diseases

Bazzano, L., Reynolds, K., Holder, K. N., & He, J. (2006) · JAMA · doi:10.1001/jama.296.22.2720 · Cited by 426 · see citing works

Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway

Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., & Rabinowitz, J. D. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.016 · Cited by 419 · see citing works

Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia

Kikuchi, G., Motokawa, Y., Yoshida, T., & Hiraga, K. (2008) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.84.246 · Cited by 381 · see citing works

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Kim, D., Fiske, B. P., Birsoy, K., Freinkman, E., Kami, K., Possemato, R. L., Chudnovsky, Y., Pacold, M. E., Chen, W. W., Cantor, J. R., et al. (2015) · Nature · doi:10.1038/nature14363 · Cited by 368 · see citing works

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

Wang, J., Alexander, P. B., Wu, L. C., Hammer, R. E., Cleaver, O. B., & McKnight, S. L. (2009) · Science · doi:10.1126/science.1173288 · Cited by 365 · see citing works

Multienzyme complex for metabolic channeling in mammalian DNA replication.

Reddy, G. P. V., & Pardee, A. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.6.3312 · Cited by 353 · see citing works

Interorgan Amino Acid Transport and its Regulation

Brosnan, J. T. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.2068s · Cited by 348 · see citing works

Mammalian methylenetetrahydrofolate reductase Partial purification, properties, and inhibition by S-adenosylmethionine

Kutzbach, C., & Stokstad, E. L. R. (1971) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(71)90247-6 · Cited by 342 · see citing works

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Mullarky, E., Lucki, N. C., Beheshti Zavareh, R., Anglin, J. L., Gomes, A. P., Nicolay, B. N., Wong, J. C. Y., Christen, S., Takahashi, H., Singh, P. K., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521548113 · Cited by 333 · see citing works

Homocysteine and stroke: evidence on a causal link from mendelian randomisation

Casas, J. P., Bautista, L. E., Smeeth, L. L., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)70152-5 · Cited by 318 · see citing works

Loss of the glycine N‐methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice†

Martínez‐Chantar, M. L., Vázquez–Chantada, M., Ariz, U., Martínez, N., Varela‐Rey, M., Luka, Z., Capdevila, A., Rodríguez, J., Aransay, A. M., Matthiesen, R., et al. (2008) · Hepatology · doi:10.1002/hep.22159 · Cited by 302 · see citing works

Metabolic control of methylation and acetylation

Su, X., Wellen, K. E., & Rabinowitz, J. D. (2015) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2015.10.030 · Cited by 296 · see citing works

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

Nikkanen, J., Forsström, S., Euro, L., Paetau, I., Kohnz, R. A., Wang, L., Chilov, D., Viinamäki, J., Roivainen, A., Marjamäki, P., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.019 · Cited by 285 · see citing works

Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

Chattopadhyay, S., Moran, R. G., & Goldman, I. D. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0343 · Cited by 281 · see citing works

Is it time to reevaluate methyl balance in humans?

Stead, L. M., Brosnan, J. T., Brosnan, M. E., Vance, D. E., & Jacobs, R. L. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.1.5 · Cited by 278 · see citing works

Cytoplasmic Serine Hydroxymethyltransferase Mediates Competition between Folate-dependent Deoxyribonucleotide andS-Adenosylmethionine Biosyntheses

Herbig, K., Chiang, E. I., Lee, L.-R., Hills, J., Shane, B., & Stover, P. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205000200 · Cited by 264 · see citing works

Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.

Goyette, P., Frosst, P. D., Rosenblatt, D. S., & Rozen, R. R. (1995) · Europe PMC (PubMed Central) · Cited by 261 · see citing works

Resistance to antifolates

Zhao, R., & Goldman, I. D. (2003) · Oncogene · doi:10.1038/sj.onc.1206946 · Cited by 254 · see citing works

A Functional Transsulfuration Pathway in the Brain Links to Glutathione Homeostasis

Vitvitsky, V., THOMAS, M. P., Ghorpade, A., Gendelman, H. E., & Banerjee, R. V. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602799200 · Cited by 242 · see citing works

Spatial colocalization and functional link of purinosomes with mitochondria

French, J. B., Jones, S. A., Deng, H., Pedley, A. M., Kim, D., Chan, C. Y., Hu, H., Pugh, R. J., Zhao, H., Zhang, Y., et al. (2016) · Science · doi:10.1126/science.aac6054 · Cited by 241 · see citing works

Methotrexate as the "anchor drug" for the treatment of early rheumatoid arthritis.

Pincus, T., Yazıcı, Y., Sokka, T., Aletaha, D., & Smolen, J. S. (2003) · PubMed · Cited by 237 · see citing works

Deletion of Betaine-Homocysteine S-Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas

Teng, Y., Mehedint, M. G., Garrow, T. A., & Zeisel, S. H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.265348 · Cited by 223 · see citing works

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis

Griss, T., Vincent, E. E., Egnatchik, R. A., Chen, J., Ma, E. H., Faubert, B., Viollet, B., DeBerardinis, R. J., & Jones, R. G. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002309 · Cited by 211 · see citing works

Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?

Pajares, M. A., & Pérez‐Sala, D. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6249-6 · Cited by 203 · see citing works

SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

Anderson, D. D., & Stover, P. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005839 · Cited by 199 · see citing works

Glycine N-Methyltransferase and Regulation of S-Adenosylmethionine Levels

Luka, Z., Mudd, S. H., & Wagner, C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.019273 · Cited by 192 · see citing works

Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage

Bailey, L. B., & Berry, R. J. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1213 · Cited by 187 · see citing works

Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

Anderson, D. D., Quintero, C. M., & Stover, P. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103623108 · Cited by 186 · see citing works

Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK

Wright, A. J. A., Dainty, J. R., & Finglas, P. M. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507777140 · Cited by 186 · see citing works

Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation

Tucker, E. J., Hershman, S. G., Köhrer, C., Belcher-Timme, C. A., Patel, J., Goldberger, O., Christodoulou, J., Silberstein, J. M., McKenzie, M., Ryan, M. T., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.010 · Cited by 176 · see citing works

Methyl balance and transmethylation fluxes in humans

Mudd, S. H., Brosnan, J. T., Brosnan, M. E., Jacobs, R. L., Stabler, S. P., Allen, R. H., Vance, D. E., & Wagner, C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.19 · Cited by 175 · see citing works

Insights into metabolic mechanisms underlying folate‐responsive neural tube defects: A minireview

Beaudin, A. E., & Stover, P. J. (2009) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20553 · Cited by 164 · see citing works

Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Lee, G. Y., Haverty, P. M., Li, L., Kljavin, N. M., Bourgon, R., Lee, J., Stern, H. M., Modrusan, Z. D., Seshagiri, S., Zhang, Z., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2683 · Cited by 162 · see citing works

Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality

Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300507200 · Cited by 161 · cited 1× · see citing works

Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice

Momb, J., Lewandowski, J. P., Bryant, J. D., Fitch, R. D., Surman, D. R., Vokes, S. A., & Appling, D. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211199110 · Cited by 160 · see citing works

Characterization of the Usage of the Serine Metabolic Network in Human Cancer

Mehrmohamadi, M., Liu, X., Shestov, A. A., & Locasale, J. W. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.026 · Cited by 157 · see citing works

Targeting MTHFD2 in acute myeloid leukemia

Pikman, Y., Puissant, A., Alexe, G., Furman, A. A., Chen, L. M., Frumm, S. M., Ross, L. S., Fenouille, N., Bassil, C. F., Lewis, C. A., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151574 · Cited by 157 · see citing works

Serine hydroxymethyltransferase revisited

Schirch, V., & Szebenyi, D. M. E. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.08.017 · Cited by 156 · see citing works

Neu-Laxova Syndrome Is a Heterogeneous Metabolic Disorder Caused by Defects in Enzymes of the L-Serine Biosynthesis Pathway

Acuña‐Hidalgo, R., Schanze, D., Kariminejad, A., Nordgren, A., Kariminejad, M. H., Conner, P., Grigelioniené, G., Nilsson, D., Nordenskjöld, M., Wedell, A., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.07.012 · Cited by 153 · see citing works

Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor

Davis, S. R., Stacpoole, P. W., Williamson, J., Kick, L. S., Quinlivan, E. P., Coats, B. S., Shane, B., Bailey, L. B., & Gregory, J. F. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00351.2003 · Cited by 149 · see citing works

Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice

MacFarlane, A. J., Liu, X., Perry, C. A., Flodby, P., Allen, R. H., Stabler, S. P., & Stover, P. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802671200 · Cited by 148 · see citing works

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

Naj, A. C., Beecham, G. W., Martin, E. R., Gallins, P. J., Powell, E. H., Konidari, I., Whitehead, P. L., Cai, G., Haroutunian, V. H., Scott, W. K., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001130 · Cited by 147 · see citing works

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

Kelly, R. S., Heiden, M. G. V., Giovannucci, E. L., & Mucci, L. A. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-1223 · Cited by 146 · see citing works

Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition

Racanelli, A. C., Rothbart, S. B., Heyer, C. L., & Moran, R. G. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4979 · Cited by 145 · see citing works

Biology of the Major Facilitative Folate Transporters SLC19A1 and SLC46A1

Hou, Z., & Matherly, L. H. (2014) · Current topics in membranes · doi:10.1016/b978-0-12-800223-0.00004-9 · Cited by 144 · see citing works

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice

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