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Cited by 8Cleft Lip and Palate ResearchPharmacological Effects and Toxicity StudiesPregnancy and Medication Impact

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

The potential role for corticosterone in the induction of cleft palate in mice after treatment with a selective NK-1 receptor antagonist, casopitant (GW679769B)

Ziejewski, Mary K., Solomon, Howard M., Stanislaus, Dinesh, Clark, Robert L., White, Tacey E., Apostoli, April R.·2012·Birth Defects Research Part B: Developmental and Reproductive Toxicology
DOI 10.1002/bdrb.20341
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Abstract

BACKGROUND: Casopitant is a potent and selective NK‐1 receptor antagonist that has shown clinical efficacy in the prevention of chemotherapy‐induced and postoperative‐induced nausea and vomiting. METHODS: In an embryo‐fetal development study, pregnant mice were given vehicle (sterile water) or doses of 30, 100, or 300 mg/kg/day casopitant on Gestation Day (GD) 6 to 15. Fetuses were evaluated for external, visceral, and skeletal abnormalities on GD 18. In a follow‐on study to investigate casopitant‐induced hormonal changes during the developmental period for palate formation, pregnant mice were given vehicle (sterile water) or 300 mg/kg/day casopitant once daily on GD 6 to 13. Blood was collected on GD 13 at various time‐points for measurement of plasma adrenocorticotropic hormone and corticosterone (CRT) concentrations. RESULTS: There was no evidence of developmental toxicity in mice at 30 or 100 mg/kg/day but 9% of fetuses at 300 mg/kg/day had cleft palate. Mice are sensitive to glucocorticoid‐induced cleft palates, and NK‐1 antagonists are known to modulate the hypothalamic–pituitary–adrenal axis leading to increases in corticosterone. On GD 13, mean plasma adrenocorticotropic hormone levels at 300 mg/kg/day were elevated by approximately twofold from vehicle‐treated levels at 1 hr post‐dose and mean plasma CRT levels were elevated by 3, 5, and 10‐fold at 0.5, 1, and 2 hr post‐dose, respectively. CONCLUSIONS: The increased level of CRT was in the range previously shown in the literature to cause cleft palates in mice and was likely the underlying mechanism behind casopitant‐induced cleft palate in mice.

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Crossref · 10.1002/bdrb.20341

Cites

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Citations

Cites

Research works printed but not linked: 6

  1. Conover SJ, 1980, Practical nonparametric statistics, 230
  2. 10.1002/(SICI)1096-9926(199711)56:5<335::AID-TERA7>3.0.CO;2-W · DOI
  3. Harrison S, 2001, Substance P. Int J Biochem Cell Biol, 33, 55
  4. Salomon DS, 1980, Current research trends in prenatal craniofacial development, 367
  5. SAS Institute, 1990, SAS/STAT USERS Guide
  6. Staples RE., 1974, Detection of visceral alterations in mammalian fetuses, Teratology, 9, A37

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Metadata

Authors
Ziejewski, M. K., Solomon, H. M., Stanislaus, D., Clark, R. L., White, T. E., & Apostoli, A. R.
Affiliations
  • GlaxoSmithKline (United States) (US)
  • Artemis (United States) (US)
  • Department of Small Animal Development and Reproductive Toxicology Covance Laboratories, Inc. Vienna Virginia
Corresponding author
Ziejewski, Mary K.
ORCID
Venue
Birth Defects Research Part B: Developmental and Reproductive Toxicology
Publisher
Wiley
Published
2011-11-29
Volume
95
Issue
1
Pages
54-62
ISSN
  • 1542-9733 (ISSN-L)
  • 1542-9741
DOI
10.1002/bdrb.20341
OpenAlex
W1996335987
Cited by
8
References
41
Citations by year
2021: 2 · 2020: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
FWCI
0.40
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Birth Defects Research Part B Developmental and Reproductive Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
GlaxoSmithKline
Topics
  • Health Sciences › Dentistry › Oral Surgery › Cleft Lip and Palate Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
NK1 receptor antagonists, cleft palate, corticosterone, ACTH, embryo-fetal development, developmental toxicity, hypothalamic-pituitary-adrenal axis, prenatal drug exposure, nausea and vomiting prevention
MeSH terms
Adrenocorticotropic Hormone, Animals, Cesarean Section, Cleft Palate, Corticosterone, Feeding Behavior, Female, Piperazines, Piperidines, Pregnancy, Urea, Weight Gain, Receptors, Neurokinin-1, Fetal Development, Mice, Neurokinin-1 Receptor Antagonists

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