The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The dynamics of cell cycle regulation
Abstract
Major events of the cell cycle—DNA synthesis, mitosis and cell division—are regulated by a complex network of protein interactions that control the activities of cyclin‐dependent kinases. The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. Computer simulations are necessary for detailed quantitative comparisons between theory and experiment, but they give little insight into the qualitative dynamics of the control system and how molecular interactions determine the fundamental physiological properties of cell replication. To that end, bifurcation diagrams are a useful analytical tool, providing new views of the dynamical organization of the cell cycle, the role of checkpoints in assuring the integrity of the genome, and the abnormal regulation of cell cycle events in mutants. These claims are demonstrated by an analysis of cell cycle regulation in fission yeast. BioEssays 24:1095–1109, 2002. © 2002 Wiley‐Periodicals, Inc.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
From molecular to modular cell biology.
Hartwell, L. H., Hopfield, J. J., Leibler, S., & Murray, A. W. (1999) · Nature · doi:10.1038/35011540 · Cited by 3,632
Cited by
Complex networks: structure and dynamics
BOCCALETTI, S., LATORA, V, MORENO, Y., CHAVEZ, M., & HWANG, D. (2006) · Physics Reports · doi:10.1016/j.physrep.2005.10.009 · Cited by 11,010
Network biology: understanding the cell's functional organization
Barabási, A.-L., & Oltvai, Z. N. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1272 · Cited by 7,903
Network motifs: theory and experimental approaches
Alon, U. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2102 · Cited by 3,279
Integrative Analysis of Cell Cycle Control in Budding Yeast
Chen, K. C., Calzone, L., Csikasz-Nagy, A., Cross, F. R., Novak, B., & Tyson, J. J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0794 · Cited by 632
Self-citationThe Bare Bones of Sex: Part 1—Sex and Gender
Fausto‐Sterling, A. (2005) · Signs: Journal of Women in Culture and Society · doi:10.1086/424932 · Cited by 437
Metadata
- Authors
- Tyson, J. J., Csikasz‐Nagy, A., & Novak, B.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2002-11-22
- Volume
- 24
- Issue
- 12
- Pages
- 1095-1109
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2065949669
- Cited by
- 315
- References
- 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The dynamics of cell cycle regulation. https://app.cochat.ai/papers/10.1002/bies.10191
- The paper
- Tyson, J. J., Csikasz‐Nagy, A., & Novak, B. (2002). The dynamics of cell cycle regulation. BioEssays. https://doi.org/10.1002/bies.10191
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
