The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular architecture of intermediate filaments
Abstract
Together with microtubules and actin microfilaments, ∼11 nm wide intermediate filaments (IFs) constitute the integrated, dynamic filament network present in the cytoplasm of metazoan cells. This network is critically involved in division, motility and other cellular processes. While the structures of microtubules and microfilaments are known in atomic detail, IF architecture is presently much less understood. The elementary ‘building block’ of IFs is a highly elongated, rod‐like dimer based on an α‐helical coiled‐coil structure. Assembly of cytoplasmic IF proteins, such as vimentin, begins with a lateral association of dimers into tetramers and gradually into the so‐called unit‐length filaments (ULFs). Subsequently ULFs start to anneal longitudinally, ultimately yielding mature IFs after a compaction step. For nuclear lamins, however, assembly starts with a head‐to‐tail association of dimers. Recently, X‐ray crystallographic data were obtained for several fragments of the vimentin dimer. Based on the dimer structure, molecular models of the tetramer and the entire filament are now a possibility. BioEssays 25:243–251, 2003. © 2003 Wiley Periodicals, Inc.
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Cites
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · cited 1×
“Such a structure would resemble the fourstranded SNARE complex that has been studied by X-ray crystallography.((44)) We note that, like IFs, the SNARE complex exhibits significant stability as well as dynamic association– dissociation capability, which are both essential for its function during membrane fusion.”
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Cited by
The cornified envelope: a model of cell death in the skin
Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776
Paircoil2: improved prediction of coiled coils from sequence.
McDonnell, A. V., Jiang, T., Keating, A. E., & Berger, B. (2006) · Bioinformatics · doi:10.1093/bioinformatics/bti797 · Cited by 424
Luesse, D. R., DeBlasio, S. L., & Hangarter, R. P. (2006) · Plant Physiology · doi:10.1104/pp.106.080333 · Cited by 74
Hollemeyer, K., Altmeyer, W., Heinzle, E., & Pitra, C. (2012) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.6277 · Cited by 53
A-type nuclear lamins, progerias and other degenerative disorders
Smith, E. D., Kudlow, B. A., Frock, R. L., & Kennedy, B. K. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.10.006 · Cited by 47
Metadata
- Authors
- Strelkov, S. V., Herrmann, H., & Aebi, U.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2003-02-20
- Volume
- 25
- Issue
- 3
- Pages
- 243-251
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2063742006
- Cited by
- 257
- References
- 1
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.