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Cited by 257

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Molecular architecture of intermediate filaments

Strelkov, Sergei V., Herrmann, Harald, Aebi, Ueli·2003·BioEssays

Abstract

Together with microtubules and actin microfilaments, ∼11 nm wide intermediate filaments (IFs) constitute the integrated, dynamic filament network present in the cytoplasm of metazoan cells. This network is critically involved in division, motility and other cellular processes. While the structures of microtubules and microfilaments are known in atomic detail, IF architecture is presently much less understood. The elementary ‘building block’ of IFs is a highly elongated, rod‐like dimer based on an α‐helical coiled‐coil structure. Assembly of cytoplasmic IF proteins, such as vimentin, begins with a lateral association of dimers into tetramers and gradually into the so‐called unit‐length filaments (ULFs). Subsequently ULFs start to anneal longitudinally, ultimately yielding mature IFs after a compaction step. For nuclear lamins, however, assembly starts with a head‐to‐tail association of dimers. Recently, X‐ray crystallographic data were obtained for several fragments of the vimentin dimer. Based on the dimer structure, molecular models of the tetramer and the entire filament are now a possibility. BioEssays 25:243–251, 2003. © 2003 Wiley Periodicals, Inc.

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Crossref · 10.1002/bies.10246

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  • Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

    Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417 · cited 1×

    “Such a structure would resemble the fourstranded SNARE complex that has been studied by X-ray crystallography.((44)) We note that, like IFs, the SNARE complex exhibits significant stability as well as dynamic association– dissociation capability, which are both essential for its function during membrane fusion.”
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Metadata

Authors
Strelkov, S. V., Herrmann, H., & Aebi, U.
Venue
BioEssays
Publisher
Wiley
Published
2003-02-20
Volume
25
Issue
3
Pages
243-251
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
OpenAlex
W2063742006
Cited by
257
References
1
FWCI
1.46
Type
journal article
Language
en
Open access
closed

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