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Cited by 175

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Mammalian DNA single‐strand break repair: an X‐ra(y)ted affair

Open access
Caldecott, Keith W.·2001·BioEssays

Abstract

The genetic stability of living cells is continuously threatened by the presence of endogenous reactive oxygen species and other genotoxic molecules. Of particular threat are the thousands of DNA single‐strand breaks that arise in each cell, each day, both directly from disintegration of damaged sugars and indirectly from the excision repair of damaged bases. If un‐repaired, single‐strand breaks can be converted into double‐strand breaks during DNA replication, potentially resulting in chromosomal rearrangement and genetic deletion. Consequently, cells have adopted multiple pathways to ensure the rapid and efficient removal of single‐strand breaks. A general feature of these pathways appears to be the extensive employment of protein–protein interactions to stimulate both the individual component steps and the overall repair reaction. Our current understanding of DNA single‐strand break repair is discussed, and testable models for the architectural coordination of this important process are presented. BioEssays 23:447–455, 2001. © 2001 John Wiley & Sons, Inc.

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Metadata

Authors
Caldecott, K. W.
Venue
BioEssays
Publisher
Wiley
Published
2001-04-30
Volume
23
Issue
5
Pages
447-455
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
OpenAlex
W2037322743
Cited by
175
References
4
FWCI
0.65
Type
journal article
Language
en
Open access
green

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