The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Polycystins and mechanosensation in renal and nodal cilia
Abstract
The external surfaces of the human body, as well as its internal organs, constantly experience different kinds of mechanical stimulations. For example, tubular epithelial cells of the kidney are continuously exposed to a variety of mechanical forces, such as fluid flow shear stress within the lumen of th nephron. The majority of epithelial cells along the nephron, except intercalated cells, possess a primary cilium, an organelle projecting from the cell's apical surface into the luminal space. Despite its discovery over 100 years ago, the primary cilium's function continued to elude researchers for many decades. However, recent studies indicate that renal cilia have a sensory function. Studies on polycystic kidney disease (PKD) have identified many of the molecular players, which should help solve the mystery of how the renal cilium senses fluid flow. In this review, we will summarize the recent breakthroughs in PKD research and discuss the role(s) of th polycystin signaling complex in mediating mechanosensory function by the primary cilium of renal epithelium as well as of the embryonic node. BioEssays 26:844–856, 2004. © 2004 Wiley Periodicals, Inc.
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Cites
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
Nauli, S. M., Alenghat, F. J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A. E. H., Lu, W., Brown, E. M., Quinn, S. J., et al. (2003) · Nature Genetics · doi:10.1038/ng1076 · Cited by 2,057
Self-citationPazour, G. J., Dickert, B. L., Vucica, Y., Seeley, E. S., Rosenbaum, J. L., Witman, G. B., & Cole, D. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.709 · Cited by 1,147
Yoder, B. K., Hou, X., & Guay-Woodford, L. M. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000029587.47950.25 · Cited by 935
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
Barr, M. M., & Sternberg, P. W. (1999) · Nature · doi:10.1038/43913 · Cited by 541
Pazour, G. J., San Agustin, J. T., Follit, J. A., Rosenbaum, J. L., & Witman, G. B. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00877-1 · Cited by 531
Localization of 5-HT6 receptors at the plasma membrane of neuronal cilia in the rat brain
Brailov, I., Bancila, M., Brisorgueil, M.-J., Miquel, M.-C., Hamon, M., & Vergé, D. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02519-1 · Cited by 245
Romio, L., Wright, V., Price, K., Winyard, P. J. D., Donnai, D., Porteous, M. E., Franco, B., Giorgio, G., Malcolm, S., Woolf, A. S., et al. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000054497.48394.d2 · Cited by 103
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Calcium's Role in Mechanotransduction during Muscle Development
Benavides Damm, T., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,502
Cell Mechanics: Integrating Cell Responses to Mechanical Stimuli
Janmey, P. A., & McCulloch, C. A. (2007) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.9.060906.151927 · Cited by 630
PDGFRαα Signaling Is Regulated through the Primary Cilium in Fibroblasts
Schneider, L., Clement, C. A., Teilmann, S. C., Pazour, G. J., Hoffmann, E. K., Satir, P., & Christensen, S. T. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.012 · Cited by 592
Nauli, S. M., Kawanabe, Y., Kaminski, J. J., Pearce, W. J., Ingber, D. E., & Zhou, J. (2008) · Circulation · doi:10.1161/circulationaha.107.710111 · Cited by 466
Self-citationNEURONAL SUBSTRATES OF COMPLEX BEHAVIORS IN C. ELEGANS
Bono, M. D., & Villu Maricq, A. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144259 · Cited by 405
Metadata
- Authors
- Nauli, S. M., & Zhou, J.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2004-07-19
- Volume
- 26
- Issue
- 8
- Pages
- 844-856
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2075591864
- Cited by
- 216
- References
- 7
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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