Insulin and its receptor: structure, function and evolution

Cited by (348)

Items 201–300 of 348

1. Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2
   Siddarth Agrawal, Marta Woźniak, Mateusz Łuc, Sebastian Makuch, Ewa Pielka, Anil Kumar Agrawal, Joanna Wietrzyk, Joanna Banach, Andrzej Gamian, Monika Pizon et al. · 2019 · Scientific Reports
2. Free fatty acid receptor 1: a ray of hope in the therapy of type 2 diabetes mellitus
   Arpita Arora, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sridevi Chigurupati, Rajwinder Kaur, Saurabh Bhatia, Ahmed Al‐Harrasi, Celia Bertha Vargas-De-La-Cruz et al. · 2021 · Inflammopharmacology
3. High-fat diet induced alterations in plasma membrane cholesterol content impairs insulin receptor binding and signalling in mouse liver but is ameliorated by atorvastatin
   Thiru Sabapathy, Erik Helmerhorst, Gaewyn Ellison, Stephanie Claire Bridgeman, Cyril D S Mamotte · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
4. Effects of laparoscopic Roux-en-Y gastric bypass on glucose-6 phosphate dehydrogenase activity in obese type 2 diabetics
   Andrew M. Schneider, Dhwajbahadur K. Rawat, L. Steve Weinstein, Sachin A. Gupte, William O. Richards · 2011 · Surgical Endoscopy
5. In vitro silencing of the insulin receptor attenuates cellular accumulation of fibronectin in renal mesangial cells
   Naohiro Yano, Daisuke Suzuki, Masayuki Endoh, Weizhi Zhang, Yan Chun Xu, James F. Padbury, Yi‐Tang Tseng · 2012 · Cell Communication and Signaling
6. Comparative analysis of tryptophan oxygenase activity and glucocorticoid receptor under the influence of insulin
   Esma R. Isenović, Zorica Žakula, Goran Korićanac, NR Stepić · 2008 · Physiological Research
7. Unraveling the Disparity of Carbohydrate Utilization in Farmed Fish: Perspectives From Comparative Pancreatic Islet Biology
   Bingyuan Yang, Qinghui Ai, Kangsen Mai · 2025 · Reviews in Aquaculture
8. IR-MBiTCN: Computational prediction of insulin receptor using deep learning: A multi-information fusion approach with multiscale bidirectional temporal convolutional network
   Farman Ali, Atef Masmoudi, Tamim Alkhalifah, Fahad Alturise, Wajdi Alghamdi, Majdi Khalid · 2025 · International Journal of Biological Macromolecules
9. Principles of Hormone Action
   Mitchell A. Lazar, Morris J. Birnbaum · 2016 · Elsevier eBooks
10. Possible Mechanisms of ω-3 PUFA Anti-tumour Action
    Michael B. Sawyer, Catherine J. Field · 2009 · Springer eBooks
11. Sustained Nrf2 Overexpression-Induced Metabolic Deregulation Can Be Attenuated by Modulating Insulin/Insulin-like Growth Factor Signaling
    Sentiljana Gumeni, Μαρία Λάμπρου, Zoi Evangelakou, Maria S. Manola, Ioannis P. Trougakos · 2023 · Cells
12. RNA interference knockdown of insulin receptor inhibits ovarian development in Chilo suppressalis
    Shuang Wu, Yan Jun Tang, Shaojun Su, Wenbing Ding, Hualiang He, Jin Xue, Qiao Gao, Lin Qiu, Youzhi Li · 2022 · Molecular Biology Reports
13. Closing in on a mechanism for activation
    Stevan R. Hubbard, W. Todd Miller · 2014 · eLife
14. Diet boosts the effectiveness of a cancer drug
    Michaël Pollak · 2018 · Nature
15. Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells
    Siddarth Agrawal, Marta Woźniak, Mateusz Łuc, K Walaszek, Ewa Pielka, Wiesław Szeja, Gabriela Pastuch-Gawołek, Andrzej Gamian, Piotr P. Ziolkowski · 2017 · Oncotarget
16. Mechanism of Insulin Action
    Morris F. White · 2016
17. Glycation restrains open-closed conformation of Insulin
    Jayanth Jeevanandam, Paramasivam Esackimuthu, N.T. Saraswathi · 2022 · Computational Biology and Chemistry
18. Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R
    Jonathan-Lee Jones, Paul W. R. Harris, Denis B. Scanlon, Briony E. Forbes, Margaret Anne Brimble, Andrew David Abell · 2016 · Organic & Biomolecular Chemistry
19. Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26
    Anastasios Papaioannou, Serdar Kuyucak B, Zdenka Kuncic · 2017 · Biochemistry and Biophysics Reports
20. Teprotumumab for Thyroid Eye Disease
    Christopher J. Hwang, Kian Eftekhari · 2020 · International Ophthalmology Clinics
21. Insulin receptor binding motif tagged with IgG4 Fc (Yiminsu) works as an insulin sensitizer to activate Akt signaling in hepatocytes
    J. Wang, T. Zou, Huixia Yang, Yanzhang Gong, X.J. Xie, Hanyu Liu, Duan-Fang Liao · 2015 · Genetics and Molecular Research
22. Navigation Between Alzheimer’s Disease (AD) and Its Various Pathophysiological Trajectories: The Pathogenic Link to Neuroimmunology—Genetics and Neuroinflammation
    Abdalla Bowirrat, Albert Pinhasov, Aia Bowirrat, Rajendra Dhar Badgaiyan · 2025 · International Journal of Molecular Sciences
23. Hyperbranched Aggregation-Induced Emission Luminogen-Based Sensor Array for Highly Sensitive Discrimination of Multiple Proteins
    Shiyu Zang, Xiao Tong Dong, Haozhi Song, Xiaolei Su, Jianbo Ma, Keyan Deng, Rongli Yang, Shuo Wu · 2025 · Analytical Chemistry
24. Préparations insuliniques au cours de la dernière décennie.
    Louis Monnier, C. Colette · 2018 · Médecine des Maladies Métaboliques
25. Unraveling the Connection between PCOS and renal Complications: Current insights and Future Directions
    Haoyu Peng, Junyi Ren, Yang Zhao, Xinyi Fang, Xiaoxiao Wang, Chi Liu, Zhengwei Wan · 2025 · Diabetes Research and Clinical Practice
26. Interactions of insulin with tragacanthic acid biopolymer: Experimental and computational study
    Komail Sadrjavadi, Ebrahim Barzegari, Salar Khaledian, Hossein Derakhshankhah, Ali Fattahi · 2020 · International Journal of Biological Macromolecules
27. Viral insulin/IGF-like peptides inhibit IGF-1 receptor signaling to enhance viral replication
    Aurélien Chuard, Kalaimagal Nesarajah, Khadija Danazumi, Kaitlin Reiners, Zhang Fa, Lev Levintov, Marta Lubos, Lenka Žáková, Rachel Ruggera, Sarah K. McMenamin et al. · 2025 · Cell Reports
28. New Target Genes for the Peroxisome Proliferator‐Activated Receptor‐γ (PPARγ) Antitumour Activity: Perspectives from the Insulin Receptor
    DANIELA PATRIZIA FOTI, Francesco Paonessa, EUSEBIO D. CHIEFARI, Antonio Brunetti · 2009 · PPAR Research
29. Anti-tumor Activity of IGF-1R Kinase Inhibitor PQIP in Colon Cancer
    Sanjib Chowdhury · 2011 · Clinical and Experimental Pharmacology
30. Molecular Modeling and Bioinformatics Analysis of Drug-Receptor Interactions in the System Formed by Glargine, Its Metabolite M1, the Insulin Receptor, and the IGF1 Receptor
    Margarita González, Claudio Gómez · 2021 · Bioinformatics and Biology Insights
31. Structural models of viral insulin‐like peptides and their analogs
    Biswajit Gorai, Harish Vashisth · 2022 · Proteins Structure Function and Bioinformatics
32. Insulin receptor‐like ectodomain genes and splice variants are found in both arthropods and human brain cDNA
    Åke Västermark, Mathias Rask‐Andersen, Rahul S. Sawant, Jill L. Reiter, Helgi B. Schiöth, Michael J. Williams · 2013 · Journal of Systematics and Evolution
33. Teprotumumab: The First Approved Biologic for Thyroid Eye Disease
    Christopher J. Hwang, Kian Eftekhari · 2021 · International Ophthalmology Clinics
34. The role of insulin-like growth factors (IGF) in cell division processes and in malignancy
    Péter Vasas, Marc C. Winslet, Shi Yu Yang · 2009 · Orvosi Hetilap
35. Analogues et dosages d’insuline : le cas général et le cas particulier de la glargine
    Arnaud Agin, R Sapin · 2010 · Médecine Nucléaire
36. Exercise Suppresses Insulin Resistance: A Potential Mechanism for Improving the Interaction Between Type 2 Diabetes and Alzheimer’s Disease
    Bo Wang, Yuping Shao, Rongxiang Liang · 2026 · Journal of Integrative Neuroscience
37. The nature of the binding between insulin receptor and serotonin transporter in placenta (review)
    Fusun Kilic · 2023 · Placenta
38. Biochemical Toxicological Study of Insulin Overdose in Rats: A Forensic Perspective
    Cunhao Bian, Xin He, Qi Wang, Zhe Zheng, Yongtai Zhang, Hongli Xiong, Yongguo Li, Mingzhu Zhao, Jianbo Li · 2023 · Toxics
39. Structural basis for the poisonous activity of a predator's venom insulin
    Pierre DE MEYTS · 2016 · Nature Structural & Molecular Biology
40. Molecular aspects and biochemical regulation of diabetes mellitus
    Daniel Gyamfi, Enoch Ofori Awuah, Stephen Owusu · 2019 · Elsevier eBooks
41. Insulin and Insulin-Like Growth Factor-1 Associated Cancers
    Sanjay Kumar Dey, Sabyasachi Senapati · 2021 · Springer eBooks
42. Examination of the potential roles of insulin-like peptide receptor in regulating the growth of Manila clam Ruditapes philippinarum
    Zhihui Yin, Zhengxing Wang, Yanming Zhang, Xuwang Yin, Xiwu Yan, Bin Wang, Hongtao Nie · 2022 · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology
43. Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
    Jiřı́ Jiráček, Irena Selicharová, Lenka Žáková · 2023 · Vitamins and hormones
44. Endocrine state is the physical manifestation of subjective beliefs
    Trenton G. Smith · 2023 · Journal of Economic Psychology
45. Si l'ère des insulines semi-synthétiques et biosynthétiques nous était contée
    L. Monnier, C Colette, David R. Owens · 2021 · Médecine des Maladies Métaboliques
46. Insulin‐like growth factor‐1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression
    Young Wha Koh, Dok Hyun Yoon, Cheolwon Suh, Hee Jeong Cha, Jooryung Huh · 2015 · International Journal of Experimental Pathology
47. Radiolabeled hormones in insulin research, a minireview
    Jiřı́ Jiráček, Lenka Žáková, Aleš Marek · 2020 · Journal of Labelled Compounds and Radiopharmaceuticals
48. The role of nutrition in prostate cancer risk, progression, and mortality: A comprehensive review
    Ariela Aline Souroujon Torun, Vinaik Mootha Sundaresan, Aleksandra Golos, Michael S. Leapman, O.A. Gomez-Santamaría, Marianne Casilla-Lennon · 2026 · Clinical Nutrition ESPEN
49. Two cases of fatal insulin homicide resolved using combined immunohistochemistry and immunofluorescence techniques
    Yiling Li, Zhonghao Yu, Yuhao Yuan, Jiaxin Zhang, Shuquan Zhao, Yijie Duan, Yiwu Zhou · 2024 · Forensic Science Medicine and Pathology
50. Formulation approaches and strategies for transdermal delivery of insulin: special emphasis on microneedle-based systems
    Eileen Hulambukie, Mengyang Liu, Wei Wu, Xidong Xiang, Sara M. Hanning, Jingyuan Wen · 2025 · Acta Materia Medica
51. Effect of a monoclonal antibody against human relaxin-2 on cancer cell growth inhibition
    Byoung Kwon Park, Su In Lee, Younghee Lee, Sooyoung Cho, Young Seek Lee, Hyung‐Joo Kwon · 2016 · Applied Biological Chemistry
52. Electronic structure and reactivity of heme bound insulin
    Madhuparna Roy, Ishita Pal, Chinmay Dey, Abhishek Dey, Somdatta Ghosh Dey · 2021 · Journal of Porphyrins and Phthalocyanines
53. Efficacy, Pharmacokinetics, Biodistribution and Excretion of a Novel Acylated Long-Acting Insulin Analogue INS061 in Rats
    Kai Pan, Xiaolei Shi, Kai Liu, Wang Ju, Yijun Chen · 2021 · Drug Design Development and Therapy
54. Pancreatic Hormones
    Pierre DE MEYTS, Pierre J. Lefèbvre · 2019 · Elsevier eBooks
55. Identification of a Novel Mutation in Patients with Type A Insulin Resistance Syndrome
    Liling Zhao, Hongmei Dai, Qin Zhang, Wenmu Hu, Ping Jin · 2022 · Human Heredity
56. The Mechanisms of Insulin Action
    Morris F. White, Kyle D. Copps, Umut Özcan, Yolanda D. Tseng · 2010 · Elsevier eBooks
57. Molecular insights into insulin-like signaling and its positive role in growth of the bivalve Mulinia lateralis
    Lingling Kong, Xiangfu Kong, Deting Meng, Xiangchao Zhang, Jie Meng, Zhenmin Bao, Xiaoli Hu · 2026 · Marine Life Science & Technology
58. Bioinformatics and Molecular Modeling of the Camel Insulin Receptor
    Mahmoud K Kandeel, Mahmoud G. El Sebaei, Mohammed M. Ba Abdullah, Saad I. Al-Sultan, Sherief Mohamed Abdel-Raheem · 2022 · Journal of Camel Practice and Research
59. Cinnamon Modulates Toll-Like Receptors: a New Therapeutic Approach for Diabetes
    Amirhossein Niknejad, Seyed Mehrad Razavi, Yasamin Hosseini, Zahra Najafi Arab, Amir Hossein Abdolghaffari, Saeideh Momtaz · 2023 · Revista Brasileira de Farmacognosia
60. Spontaneous Dimerization and Distinct Packing Modes of Transmembrane Domains in Receptor Tyrosine Kinases
    Lev Levintov, Biswajit Gorai, Harish Vashisth · 2024 · Biochemistry
61. Anionic Lipid Catalyzes the Generation of Cytotoxic Insulin Oligomers
    Jhinuk Saha, Audrey Wolszczak, Navneet Kaur, Malitha C. Dickwella Widanage, Samuel D. McCalpin, Riqiang Fu, Jamel Ali, Ayyalusamy Ramamoorthy · 2025 · Biomolecules
62. PeptideMiner—neuropeptide discovery across the animal kingdom
    Helen C. Mendel, Gene Hopping, Eivind A. B. Undheim, Johannes Zuegg, Richard James Lewis, Briony E. Forbes, Quentin Kaas, Markus Muttenthaler · 2025 · GigaScience
63. Effect of a Mixture of Plants Extracts on Genomic DNA, Insulin Receptor, and Insulin Receptor Substrate-1 Genes in Alloxan-Induced Diabetic Male Rats.
    Maysaa Adil Al-Joubori, Ali Hmood Al-Saadi, Haider Kamil Zaidan · 2013 · Journal of Biology Agriculture and Healthcare
64. Association of IGF1R polymorphisms with the development of HBV ‐related hepatocellular carcinoma
    Haiyang Xie, Chunyang Xing, B.‐J. Wei, Xianglai Xu, Jian Wu, Liming Chen, G.‐Q. Cao, Huafeng Chen, Kejun Chen, S.‐Y. Yin et al. · 2014 · Tissue Antigens
65. Effects of dexamethasone on insulin receptor in aging
    Goran Korićanac, Mojca Stojiljković, Snežana Radivojša, Zorica Žakula, N Ribarac-Stepić, Esma R. Isenović · 2008 · Acta Biologica Hungarica
66. A receptor state space model of the insulin signalling system in glucose transport
    Catheryn W. Gray, Adelle C.F. Coster · 2015 · Mathematical Medicine and Biology A Journal of the IMA
67. Insulin and insulin-like growth factor pathway, a new targeted therapy in oncology
    Joaquim Bosch‐Barrera, Alberto Carabias Hernández, L. Abella · 2010 · Anales del Sistema Sanitario de Navarra
68. Practical aspects of usage of insulin in India: Descriptive review and key recommendations
    Jagat Jyoti Mukherjee, Rajesh Rajput, Sujoy Majumdar, Banshi Saboo, Sanjay Chatterjee · 2021 · Diabetes & Metabolic Syndrome Clinical Research & Reviews
69. Die schnelle Stoffwechselregulation
    Harald Staiger, Norbert Stefan, Monika Kellerer, Hans‐Ulrich Häring · 2007 · Springer-Lehrbuch
70. Molecular simulation studies of the insulin receptor family
    Harish Vashisth, Cameron F. Abrams · 2010
71. A Comparative Genomics Exploration of Inter-partner Metabolic Signaling in the Coral-algal Symbiosis
    Katherine E. Dougan · 2020
72. Mechanism of Insulin Action
    Morris F. White · 2024
73. Viral Insulin/IGF-like Peptides Selectively Activate Host Insulin/IGF Signaling pathways during Grouper Iridovirus Infection
    Aurélien Chuard, Kalaimagal Nesarajah, Khadija Danazumi, Kaitlin Reiners, Zhang Fa, Lev Levintov, Harish Vashisth, Richard D. DiMarchi, Emrah Altındiş · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
74. Classic metabolic actions of insulin in humans: from physiology to disease and novel pharmacotherapeutics
    Andrew J. Krentz · 2023 · Elsevier eBooks
75. Genealogical Rabson–Mendenhall syndrome caused by INSR gene mutation
    Xuewen Yuan, Ziyang Zhu, Chao Liang · 2025 · American Journal of Physiology-Endocrinology and Metabolism
76. A de novo INSR variant in Type A insulin resistance syndrome: familial investigation and genetic implications
    Xin Lin, Ziyan Zoe Xu, Lijun Xie, Juan Zhu, Hongping Yu, Ruo-li Wang, Yi-jia Luo, Jing Zou, Jian-hui Zhang, Qian Chen et al. · 2025 · Gene
77. Gangliosides GM3 and GD3 modulate insulin aggregation pathways and reduce cytotoxicity through structural remodeling
    Nazifa Ahmad, Jhinuk Saha, Yimin Mao, Robert Silvers, Zaid Abulaban, Joshua A. Mysona, Ayyalusamy Ramamoorthy · 2026 · International Journal of Biological Macromolecules
78. Myotube cell-based 2D-SPR sensor for insulin and its analog detection
    Yuki Shiraishi, Hiroaki Shinohara, Minoru Suga · 2017 · Biology Engineering and Medicine
79. Role of surface-exposed charged basic amino acids (Lys, Arg) and guanidination in insulin on the interaction and stability of insulin–insulin receptor complex
    Vannajan Sanghiran Lee, Sri Devi Sukumaran, Pak Kheong Tan, Umah Rani Kuppusamy, Bavani Arumugam · 2021 · Computational Biology and Chemistry
80. La vía de la insulina y el factor de crecimiento similar a la insulina, una nueva diana terapéutica en oncología
    Joaquim Bosch‐Barrera, A. Hernández, L. Abella · 2009 · Anales del Sistema Sanitario de Navarra
81. Targeting the insulin receptor with hormone and peptide dimers
    Jingjing Lin, Irena Selicharová, Katarína Mitrová, Benjamin Fabre, Vijay Madhav Miriyala, Martin Lepšı́k, Jiřı́ Jiráček, María Soledad Garre Hernández · 2022 · Journal of Peptide Science
82. La voie de signalisation type insuline dans la différenciation sexuelle chez les Crustacés isopodes - intégration de l'hormone androgène et de facteurs féminisants dans un nouveau contexte
    Benjamin Herran · 2018
83. Therapeutic potential of active principles isolated from fruits of Terminalia bellerica Roxb. in streptozotocin-induced diabetic Wistar rats
    R. Cecily Rosemary Latha · 2011 · INFLIBNET
84. The effect of plant-derived oleanolic acid on selected markers of lipid metabolism and insulin signalling pathway in streptozotocin-induced diabetic rats.
    Sandile Victor. Cele · 2013 · ResearchSpace (University of KwaZulu-Natal)
85. Insulin Receptor Complex and Signaling by Insulin
    Lindsay G. Sparrow, S. Lance Macaulay · 2010 · Elsevier eBooks
86. Gene expression in human skeletal muscle : Effects of activity, fibre type and inheritance for diabetes
    Maria Ahlsén · 2006 · Figshare
87. The potential role of bacterial metabolic toxins in the development of diabetes
    Nasrin Vassel · 2012 · ORCA Online Research @Cardiff (Cardiff University)
88. Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
    Abiy M. Mohammed · 2013 · Human Biology
89. Synthesis of nonapeptide (B22-B30) of insulin B-chain using modified solid-phase methods with and without microwave energy
    Mohamed A. Zewail, SomaiaAbdel Rahman, AhmedM Naglah · 2014 · Egyptian Pharmaceutical Journal
90. Determinants of cell cycle progression in human mammary epithelial MCF12 cells
    A Ouertani · 2012 · UCL Discovery (University College London)
91. Assessment of β-Cell Function
    Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch · 2014 · Springer eBooks
92. The susceptibility to metabolic and proliferative diseases - from genetic predisposition to treatment
    Cristina Maglio · 2014 · Gothenburg University Publications Electronic Archive (Gothenburg University)
93. Molekulare Mechanismen der IKKepsilon vermittelten Insulinresistenz in Säugermodellen
    Barbara Heese · 2007
94. The Anachronistic Terminology of Gestational Hypertension
    Richard Giovane, Shadi Rezai, Chadi Berjaoui, Cassandra E. Henderson · 2015 · Obstetrics and Gynecology
95. Implicating insulin in neoplastic growth and metabolism
    Haider Mashhedi · 2011
96. CHARACTERIZATION OF THE ONTHOPHAGUS NIGRIVENTRIS INSULIN RECEPTOR
    Laura Hahn · 2010
97. INSULIN-LIKE GROWTH FACTOR-I AND APOPTOSIS AS DETERMINANTS OF PREIMPLANTATION BOVINE EMBRYONIC DEVELOPMENT
    Frank Dean Jousan · 2006
98. [Early x-ray findings in gastritis (fundus gastritis & gastritis of the upper part of gastric corpus].
    A. Ott · 1957 · PubMed
99. DISTRIBUTION OF GHRELIN IN PANCREATIC ISLET CELLS OF NORMAL AND DIABETIC RATS AND ITS EFFECT ON DIABETES MELLITUS
    M. El Abadlah, Yoshiaki Haba · 2015
100. Tissue specificity of 17?-estradiol effects on insuli signaling pathway
     Tijana Milosavljević · 2012