Insulin and its receptor: structure, function and evolution

De Meyts, Pierre

doi:10.1002/bies.20151

Cited by 348Receptor Mechanisms and SignalingMetabolism, Diabetes, and CancerPancreatic function and diabetes

Insulin and its receptor: structure, function and evolution

De Meyts, Pierre·2004·BioEssays

DOI 10.1002/bies.20151

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Abstract

I present here a personal perspective on more than three decades of research into the structural biology of the insulin–receptor interaction. The solution of the three‐dimensional structure of insulin in 1969 provided a detailed understanding of the insulin surfaces involved in self‐assembly. In subsequent years, hundreds of insulin analogues were prepared by insulin chemists and molecular biologists, with the goal of relating the structure to the biological function of the molecule. The design of methods for direct receptor‐binding studies in the 1970s, and the cloning of the receptor in the mid 1980s, provided the required tools for detailed structure–function studies. In the absence of a full three‐dimensional structure of the insulin–receptor complex, I attempt to assemble the existing pieces of the puzzle generated by our and other laboratories, in order to generate a plausible mechanistic model of the insulin–receptor interaction that explains its kinetics and negative cooperativity. BioEssays 26:1351–1362, 2004. © 2004 Wiley Periodicals, Inc.

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Any impairments occur on main phosphorylation sites will reduce insulin receptor tyrosine kinase activity, eventually affecting the insulin function.
“Therefore, any impairments occur on main phosphorylation sites will reduce insulin receptor tyrosine kinase activity, eventually affecting the insulin function (88–90).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [90]

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Authors: De Meyts, P.
Venue: BioEssays
Publisher: Wiley
Published: 2004-11-18
Volume: 26
Issue: 12
Pages: 1351-1362
ISSN: 0265-9247 (ISSN-L)
1521-1878
DOI: 10.1002/bies.20151
OpenAlex: W1979532631
Cited by: 345
References: 71
Citations by year: 2026: 13 · 2025: 15 · 2024: 7 · 2023: 18 · 2022: 18 · 2021: 26 · 2020: 15 · 2019: 17 · 2018: 18 · 2017: 14 · 2016: 17 · 2015: 17 · 2014: 18 · 2013: 16 · 2012: 23
FWCI: 0.66
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: BioEssays (publishedVersion)
PubMed (publishedVersion)
Funders: Novo Nordisk
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords: insulin, insulin receptor, insulin analogues, receptor binding, receptor cloning, structure-function relationship, negative cooperativity
MeSH terms: Animals, Humans, Insulin, Models, Molecular, Protein Conformation, Receptor, Insulin, Somatomedins, Structure-Activity Relationship, Evolution, Molecular

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Insulin and its receptor: structure, function and evolution

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