The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
GDNF/Ret signaling and the development of the kidney
Open accessAbstract
Signaling by GDNF through the Ret receptor is required for normal growth of the ureteric bud during kidney development. However, the precise role of GDNF/Ret signaling in renal branching morphogenesis and the specific responses of ureteric bud cells to GDNF remain unclear. Recent studies have provided new insight into these issues. The localized expression of GDNF by the metanephric mesenchyme, together with several types of negative regulation, is important to elicit and correctly position the initial budding event from the Wolffian duct. GDNF also promotes the continued branching of the ureteric bud. However, it does not provide the positional information required to specify the pattern of ureteric bud growth and branching, as its site of synthesis can be drastically altered with minimal effects on kidney development. Cells that lack Ret are unable to contribute to the tip of the ureteric bud, apparently because GDNF-driven proliferation is required for the formation and growth of this specialized epithelial domain.
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Self-citationScatter factor/hepatocyte growth factor is essential for liver development
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Defects in enteric innervation and kidney development in mice lacking GDNF
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Self-citationNovel functions and signalling pathways for GDNF
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FGF10 Acts as a Major Ligand for FGF Receptor 2 IIIb in Mouse Multi-Organ Development
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Zheng, J., Wang, S., Xia, L., Sun, Z., Chan, K. M., Bernards, R., Qin, W., Chen, J., Xia, Q., & Jin, H. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02075-w · Cited by 341
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Metadata
- Authors
- Costantini, F., & Shakya, R.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2006-02
- Volume
- 28
- Issue
- 2
- Pages
- 117-127
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W1996416783
- Cited by
- 327
- References
- 78
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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