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Cited by 338

The DOI matches its Crossref record; 199 of the 199 references it cites were found in a registry or an index.

Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration

Open access
Andrew, Deborah J., Ewald, Andrew J.·2010·Developmental Biology

Abstract

Epithelial tubes are a fundamental tissue across the metazoan phyla and provide an essential functional component of many of the major organs. Recent work in flies and mammals has begun to elucidate the cellular mechanisms driving the formation, elongation and branching morphogenesis of epithelial tubes during development. Both forward and reverse genetic techniques have begun to identify critical molecular regulators for these processes and have revealed the conserved role of key pathways in regulating the growth and elaboration of tubular networks. In this review, we discuss the developmental programs driving the formation of branched epithelial networks, with specific emphasis on the trachea and salivary gland of Drosophila melanogaster and the mammalian lung, mammary gland, kidney, and salivary gland. We both highlight similarities in the development of these organs and attempt to identify tissue and organism specific strategies. Finally, we briefly consider how our understanding of the regulation of proliferation, apico-basal polarity, and epithelial motility during branching morphogenesis can be applied to understand the pathologic dysregulation of these same processes during metastatic cancer progression.

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Crossref · 10.1016/j.ydbio.2009.09.024

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Metadata

Authors
Andrew, D. J., & Ewald, A. J.
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2010-05
Volume
341
Issue
1
Pages
34-55
ISSN
0012-1606 (ISSN-L)
OpenAlex
W2022731004
Cited by
338
References
199
FWCI
8.88
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration. https://app.cochat.ai/papers/10.1016/j.ydbio.2009.09.024
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Andrew, D. J., & Ewald, A. J. (2010). Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration. Developmental Biology. https://doi.org/10.1016/j.ydbio.2009.09.024

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.