The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The RAD6 DNA repair pathway in Saccharomyces cerevisiae: What does it do, and how does it do it?
Abstract
The RAD6 pathway of budding yeast, Saccharomyces cerevisiae, is responsible for a substantial fraction of this organism's resistance to DNA damage, and also for induced mutagenesis. The pathway appears to incorporate two different recovery processes, both regulated by RAD6. The error‐prone recovery prcess accounts for only a small amount of RAD6‐dependent resistance, but probably all induced mutagenesis. The underlying mechanism, for error‐prone recovery is very likely to be translesion synthesis. The error‐free recovery process accounts for most of RAD6‐dependent resistace, but its mechanism is less clear; it may entail error‐free bypass by template switching and/or DNA gap filling by recombination. RAD6 regulates these activities by ubiquitinateins, and the roles they play in error‐free and error‐prone recovery, have not yet been established.
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Cites
Prakash, L. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00352525 · Cited by 291
DNA synthesis in UV-irradiated yeast
di Caprio, L., & Cox, B. S. (1981) · Mutation Research · doi:10.1016/0027-5107(81)90139-1 · Cited by 71
Cited by
Genome maintenance mechanisms for preventing cancer
Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939
Ubiquitin signalling in DNA replication and repair
Ulrich, H. D., & Walden, H. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2921 · Cited by 275
Ubiquitin-dependent DNA damage bypass is separable from genome replication
Daigaku, Y., Davies, A. A., & Ulrich, H. D. (2010) · Nature · doi:10.1038/nature09097 · Cited by 259
Xeroderma pigmentosum variant and error-prone DNA polymerases
Kannouche, P. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.009 · Cited by 60
Metadata
- Authors
- Lawrence, C.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1994-04
- Volume
- 16
- Issue
- 4
- Pages
- 253-258
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2146546127
- Cited by
- 188
- References
- 2
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lawrence, C. (1994). The RAD6 DNA repair pathway in Saccharomyces cerevisiae: What does it do, and how does it do it? BioEssays. https://doi.org/10.1002/bies.950160408
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