Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations
Abstract
Postreplication repair of nuclear DNA was examined in an excision defective haploid strain of yeast lacking mitochondrial DNA (rad1 rho 0). The size of the DNA synthesized in cells exposed to various fluences of ultraviolet light (UV) corresponds approximately to the average interdimer distance in the parental DNA. Upon further incubation of cells following exposure to 2.5 J/m2, the DNA increases in size; by 4 h, it corresponds to DNA from uniformly labeled cells. The alkaline sucrose sedimentation pattern of DNA pulse labeled at various times after UV irradiation, for up to 4 h, does not change substantially, indicating that dimers continue to block DNA replication. A significant amount of postreplication repair requires de novo protein synthesis, as determined by its inhibition by cycloheximide. The rad6 mutant does not carry out postreplication repair, the rad18 and rad52 mutants show great inhibition while the rev3 mutation does not affect postreplication repair. Both recombinational and nonrecombinational repair mechanisms may function in postreplication repair and most of postreplication repair is error free.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Blocked polymerases can leave the lesion and PCNA behind and re-initiate downstream via re-priming, generating numerous ssDNA gaps behind forks that likely cause strong Mec1 activation during S phase in UV-irradiated cells.
“Blocked polymerase can leave the lesion and PCNA behind and re-initiate downstream of the lesion via a re-priming mechanism, generating numerous ssDNA gaps behind the forks, which are likely responsible for the strong activation of Mec1 during S phase in UV-irradiated cells [51,82–85].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [85]
Cites
Rupp, W. D., & Howard-flanders, P. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90445-2 · Cited by 1,093 · see citing works
DNA Repair in Bacteria and Mammalian Cells
Hanawalt, P. C., Cooper, P. K., Ganesan, A. K., & Smith, C. A. (1979) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.48.070179.004031 · Cited by 837 · see citing works
Sedimentation Rate as a Measure of Molecular Weight of DNA
Burgi, E., & Hershey, A. D. (1963) · Biophysical Journal · doi:10.1016/s0006-3495(63)86823-x · Cited by 731 · see citing works
Exchanges between DNA strands in ultraviolet-irradiated Escherichia coli
Rupp, W. D., Wilde, C. E., Reno, D., & Howard-Flanders, P. (1971) · Journal of Molecular Biology · doi:10.1016/0022-2836(71)90204-x · Cited by 577 · see citing works
Goldring (1970) · doi:10.1016/0022-2836(70)90033-1 · Cited by 519 · see citing works
A genetic study of X-ray sensitive mutants in yeast
Game, J. C., & Mortimer, R. (1974) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(74)90176-6 · Cited by 477 · see citing works
Postreplication repair of DNA in ultraviolet-irradiated mammalian cells
Lehmann, A. R. (1972) · Journal of Molecular Biology · doi:10.1016/0022-2836(72)90418-4 · Cited by 437 · see citing works
MUTANTS OF YEAST DEFECTIVE IN MUTATION INDUCED BY ULTRAVIOLET LIGHT
Lemontt, J. F. (1971) · Genetics · doi:10.1093/genetics/68.1.21 · Cited by 325 · see citing works
The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast
Cox, B. S., & Parry, J. M. (1968) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(68)90101-2 · Cited by 283 · see citing works
UV MUTAGENESIS IN RADIATION-SENSITIVE STRAINS OF YEAST
Lawrence, C. W., & Christensen, R. B. (1976) · Genetics · doi:10.1093/genetics/82.2.207 · Cited by 260 · see citing works
THE ROLE OF RADIATION (rad) GENES IN MEIOTIC RECOMBINATION IN YEAST
Game, J. C., Zamb, T. J., Braun, R. J., Resnick, M. A., & Roth, R. M. (1980) · Genetics · doi:10.1093/genetics/94.1.51 · Cited by 256 · see citing works
Malone, R. E., & Esposito, R. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.1.503 · Cited by 246 · see citing works
EFFECTS OF THE RAD52 GENE ON RECOMBINATION IN SACCHAROMYCES CEREVISIAE
Prakash, S., Prakash, L., Burke, W. D., & Montelone, B. A. (1980) · Genetics · doi:10.1093/genetics/94.1.31 · Cited by 215 · see citing works
Self-citationReynolds, R. J., & Friedberg, E. C. (1981) · Journal of Bacteriology · doi:10.1128/jb.146.2.692-704.1981 · Cited by 188 · see citing works
GENETIC CONTROL OF RADIATION SENSITIVITY IN SACCHAROMYCES CEREVISIAE
Resnick, M. A. (1969) · Genetics · doi:10.1093/genetics/62.3.519 · Cited by 185 · see citing works
Lehmann, A. R., & Kirk‐Bell, S. (1972) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1972.tb02550.x · Cited by 161 · see citing works
Kutter, E. M., & Wiberg, J. S. (1968) · Journal of Molecular Biology · doi:10.1016/0022-2836(68)90394-x · Cited by 158 · see citing works
Prakash, L. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80010-6 · Cited by 155 · see citing works
Self-citationLACK OF CHEMICALLY INDUCED MUTATION IN REPAIR-DEFICIENT MUTANTS OF YEAST
Prakash, L. (1974) · Genetics · doi:10.1093/genetics/78.4.1101 · Cited by 149 · see citing works
Self-citationLawrence, C. W., Stewart, J. W., Sherman, F., & Christensen, R. B. (1974) · Journal of Molecular Biology · doi:10.1016/0022-2836(74)90134-x · Cited by 149 · see citing works
Repair systems in Saccharomyces
Cox, B. S., & Game, J. C. (1974) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(74)80023-0 · Cited by 146 · see citing works
Inducible error-prone repair in Escherichia coli.
Sedgwick, S. G. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.7.2753 · Cited by 132 · see citing works
Lauer, G. D., Roberts, T. M., & Klotz, L. C. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90175-9 · Cited by 124 · see citing works
Lawrence, C. W., & Christensen, R. B. (1978) · Genetics · doi:10.1093/genetics/90.2.213 · Cited by 117 · see citing works
Mutants of Yeast Sensitive to Ultraviolet Light
Snow, R. (1967) · Journal of Bacteriology · doi:10.1128/jb.94.3.571-575.1967 · Cited by 102 · see citing works
Park, S. D., & Cleaver, J. E. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.8.3927 · Cited by 98 · see citing works
Steps in DNA Chain Elongation and Joining after Ultra-violet Irradiation of Human Cells
Buhl, S. N., Setlow, R. B., & Regan, J. D. (1972) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553007214551301 · Cited by 96 · see citing works
Induced intragenic recombination in yeast can occur during the G1 mitotic phase
Fabre, F. (1978) · Nature · doi:10.1038/272795a0 · Cited by 92 · see citing works
The formation of pyrimidine dimers in the DNA of fungi and bacteria
Unrau, P., Wheatcroft, R., Cox, B. S., & Olive, T. (1973) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(73)90065-8 · Cited by 86 · see citing works
Replication of ultraviolet-irradiated simian virus 40 in monkey kidney cells
Sarasin, A. R., & Hanawalt, P. C. (1980) · Journal of Molecular Biology · doi:10.1016/0022-2836(80)90288-0 · Cited by 86 · see citing works
Deoxyribonucleic Acid Synthesis in Ultraviolet-Light-Irradiated Chinese Hamster Cells
Meyn, R. E., & Humphrey, R. M. (1971) · Biophysical Journal · doi:10.1016/s0006-3495(71)86215-x · Cited by 82 · see citing works
Cell cycle phase expansion in nitrogen-limited cultures of Saccharomyces cerevisiae.
Rivin, C. J., & Fangman, W. L. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.85.1.96 · Cited by 82 · see citing works
Montelone, B. A., Prakash, S., & Prakash, L. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00352514 · Cited by 80 · see citing works
Self-citationBuhl, S. N., Setlow, R. B., & Regan, J. D. (1973) · Biophysical Journal · doi:10.1016/s0006-3495(73)86061-8 · Cited by 79 · see citing works
GENETIC ANALYSIS OF GAMMA-RAY MUTAGENESIS IN YEAST. I. REVERSION IN RADIATION-SENSITIVE STRAINS
McKee, R. H., & Lawrence, C. W. (1979) · Genetics · doi:10.1093/genetics/93.2.361 · Cited by 76 · see citing works
Lawrence, C. W., & Christensen, R. B. (1979) · Genetics · doi:10.1093/genetics/92.2.397 · Cited by 76 · see citing works
LIMITED DNA SYNTHESIS IN THE ABSENCE OF PROTEIN SYNTHESIS IN PHYSARUM POLYCEPHALUM
Cummins, J., & Rusch, H. P. (1966) · The Journal of Cell Biology · doi:10.1083/jcb.31.3.577 · Cited by 74 · see citing works
Prakash, L. (1977) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(77)90038-0 · Cited by 74 · see citing works
Self-citationDNA synthesis in UV-irradiated yeast
di Caprio, L., & Cox, B. S. (1981) · Mutation Research · doi:10.1016/0027-5107(81)90139-1 · Cited by 71 · see citing works
Role of Protein Synthesis in the Replication of Yeast DNA
Hereford, L. M., & Hartwell, L. H. (1973) · Nature New Biology · doi:10.1038/newbio244129a0 · Cited by 62 · see citing works
Replication of the nuclear genome in yeast does not require concomitant protein synthesis
Williamson, D. H. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)90998-4 · Cited by 61 · see citing works
Boram, W. R., & Roman, H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.8.2828 · Cited by 59 · see citing works
The genetic control of dark recombination in yeast
HUNNABLE, E., & Cox, B. S. (1971) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(71)90040-6 · Cited by 59 · see citing works
Effects of the rad52 gene on sister chromatid recombination in Saccharomyces cerevisiae
Prakash, L., & Taillon‐Miller, P. (1981) · Current Genetics · doi:10.1007/bf00429828 · Cited by 55 · see citing works
Self-citationThe Repair of Double-Strand Breaks in Chromosomal DNA of Yeast
Resnick, M. A. (1975) · Springer eBooks · doi:10.1007/978-1-4684-2898-8_20 · Cited by 55 · see citing works
Johnston, L. H., & Williamson, D. H. (1978) · Molecular and General Genetics MGG · doi:10.1007/bf00267387 · Cited by 54 · see citing works
DNA Repair in Potorous tridactylus
Buhl, S. N., Setlow, R. B., & Regan, J. D. (1974) · Biophysical Journal · doi:10.1016/s0006-3495(74)85949-7 · Cited by 49 · see citing works
Rosenstein, B. S., & Setlow, R. B. (1980) · Biophysical Journal · doi:10.1016/s0006-3495(80)85050-8 · Cited by 44 · see citing works
Does ultraviolet light enhance postreplication repair in mammalian cells?
Painter, R. B. (1978) · Nature · doi:10.1038/275243a0 · Cited by 44 · see citing works
Pathways of ultraviolet mutability in Saccharomyces cerevisiae
Lemontt, J. F. (1971) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(71)90041-8 · Cited by 42 · see citing works
Pathways of ultraviolet mutability in Saccharomyces cerevisiae
Lemontt, J. F. (1971) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(71)90042-x · Cited by 40 · see citing works
Clark, R. W., Wever, G. H., & Wiberg, J. S. (1980) · Journal of Virology · doi:10.1128/jvi.33.1.438-448.1980 · Cited by 37 · see citing works
Correspondent, O. W. (1973) · Nature · doi:10.1038/244129a0 · Cited by 23 · see citing works
Scission of Escherichia coli deoxyribonucleic acid in alkali
Hill, W. E., & Fangman, W. L. (1973) · Biochemistry · doi:10.1021/bi00733a017 · Cited by 20 · see citing works
Genetic Analysis of Error-Prone Repair Systems in Saccharomyces cerevisiae
Prakash, L., & Prakash, S. (1980) · Springer eBooks · doi:10.1007/978-1-4684-3842-0_9 · Cited by 20 · see citing works
Self-citationGenes controlling ultraviolet mutability in yeast
Lemontt, J. F. (1973) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 16 · see citing works
Saccharomyces cerevisiaeにおける組み換え こう進した有糸分裂的遺伝子転換と関連したDNA修復変異
Boram, W. R., & Roman, H. (1976) · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function
Prakash, S., Johnson, R. E., & Prakash, L. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133250 · Cited by 999 · see citing works
Self-citationMaintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786 · see citing works
Rad6-Dependent Ubiquitination of Histone H2B in Yeast
Robzyk, K., Recht, J., & Osley, M. A. (2000) · Science · doi:10.1126/science.287.5452.501 · Cited by 666 · see citing works
Lopes, M., Foiani, M., & Sogo, J. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.015 · Cited by 563 · see citing works
Two RING finger proteins mediate cooperation between ubiquitin‐conjugating enzymes in DNA repair
Ulrich, H. D., & Jentsch, S. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3388 · Cited by 427 · see citing works
PrimPol, an Archaic Primase/Polymerase Operating in Human Cells
García-Gómez, S., Reyes, A., Martínez-Jiménez, M. I., Chocrón, E. S., Mouron, S. A., Terrados, G., Powell, C. A., SALIDO, E. C., Méndez, J., Holt, I. J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.09.025 · Cited by 407 · see citing works
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
Symington, L., Rothstein, R., & Lisby, M. (2014) · Genetics · doi:10.1534/genetics.114.166140 · Cited by 331 · see citing works
Hohmann, S. (2003) · Springer eBooks · Cited by 356 · see citing works
Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sitesPreprint
Haracska, L., Unk, I., Johnson, R. E., Johansson, E., Burgers, P., Prakash, S., & Prakash, L. (2001) · Genes & Development · doi:10.1101/gad.882301 · Cited by 347 · see citing works
Self-citationBailly, V., Lamb, J., Sung, P., Prakash, S., & Prakash, L. (1994) · Genes & Development · doi:10.1101/gad.8.7.811 · Cited by 321 · see citing works
Self-citationReplication fork reactivation downstream of a blocked nascent leading strand
Heller, R. C., & Marians, K. J. (2006) · Nature · doi:10.1038/nature04329 · Cited by 318 · see citing works
McDonald, J. P., Levine, A. S., & Woodgate, R. (1997) · Genetics · doi:10.1093/genetics/147.4.1557 · Cited by 314 · see citing works
DNA REPAIR GENES AND PROTEINS OF SACCHAROMYCES CEREVISIAE
Prakash, S., Sung, P., & Prakash, L. (1993) · Annual Review of Genetics · doi:10.1146/annurev.ge.27.120193.000341 · Cited by 303 · see citing works
Self-citationBailly, V., Lauder, S., Prakash, S., & Prakash, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.23360 · Cited by 292 · see citing works
Self-citationReplisome assembly and the direct restart of stalled replication forks
Heller, R. C., & Marians, K. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2058 · Cited by 268 · see citing works
Gasior, S. L., Wong, A. K., Kora, Y., Shinohara, A., & Bishop, D. K. (1998) · Genes & Development · doi:10.1101/gad.12.14.2208 · Cited by 262 · see citing works
Ubiquitin-dependent DNA damage bypass is separable from genome replication
Daigaku, Y., Davies, A. A., & Ulrich, H. D. (2010) · Nature · doi:10.1038/nature09097 · Cited by 259 · see citing works
SUMOylation regulates Rad18-mediated template switch
Branzei, D., Vanoli, F., & Foiani, M. (2008) · Nature · doi:10.1038/nature07587 · Cited by 259 · see citing works
In Vitro Assembly and Recognition of Lys-63 Polyubiquitin Chains
Hofmann, R. M., & Pickart, C. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103378200 · Cited by 253 · see citing works
DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae
Broomfield, S., Hryciw, T., & Xiao, W. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00091-x · Cited by 243 · see citing works
Edmunds, C. E., Simpson, L. J., & Sale, J. E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.024 · Cited by 239 · see citing works
Physical and Functional Interactions of Human DNA Polymerase η with PCNA
Haracska, L., Johnson, R. E., Unk, I., Phillips, B., Hurwitz, J., Prakash, L., & Prakash, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.21.7199-7206.2001 · Cited by 235 · see citing works
Self-citationDNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae
Boiteux, S., & Jinks-Robertson, S. (2013) · Genetics · doi:10.1534/genetics.112.145219 · Cited by 227 · see citing works
Johnson, R. E., Henderson, S. T., Petes, T. D., Prakash, S., Bankmann, M., & Prakash, L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.3807 · Cited by 224 · see citing works
Self-citationA Critical Role for the Ubiquitin-Conjugating Enzyme Ubc13 in Initiating Homologous Recombination
Zhao, G., Sonoda, E., Barber, L. J., Oka, H., Murakawa, Y., Yamada, K., Ikura, T., Wang, X., Kobayashi, M., Yamamoto, K., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.029 · Cited by 218 · see citing works
Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA
Andersen, P. L., Xu, F., & Xiao, W. (2007) · Cell Research · doi:10.1038/cr.2007.114 · Cited by 204 · see citing works
Multiple roles of Rev3, the catalytic subunit of polζ in maintaining genome stability in vertebrates
Sonoda, E., Okada, T., Zhao, G. Y., Tateishi, S., Araki, K., Yamaizumi, M., Yagi, T., Verkaik, N. S., van Gent, D. C., Takata, M., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg308 · Cited by 204 · see citing works
Haracska, L., Torres‐Ramos, C. A., Johnson, R. E., Prakash, S., & Prakash, L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4267-4274.2004 · Cited by 201 · see citing works
Self-citationSung, P., Prakash, S., & Prakash, L. (1988) · Genes & Development · doi:10.1101/gad.2.11.1476 · Cited by 194 · see citing works
Self-citationThe RAD6 DNA repair pathway in Saccharomyces cerevisiae: What does it do, and how does it do it?
Lawrence, C. W. (1994) · BioEssays · doi:10.1002/bies.950160408 · Cited by 188 · see citing works
Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA
Blastyák, A., Hajdú, I., Unk, I., & Haracska, L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00863-09 · Cited by 187 · see citing works
Zhang, H., & Lawrence, C. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504586102 · Cited by 185 · see citing works
Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance
Unk, I., Hajdú, I., Blastyák, A., & Haracska, L. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.013 · Cited by 178 · see citing works
Simon, J. A., Szankasi, P., Nguyen, D. K., Ludlow, C. L., Dunstan, H. M., Roberts, C. J., Jensen, E. L., Hartwell, L. H., & Friend, S. H. (2000) · PubMed · Cited by 183 · see citing works
Schiestl, R. H., Prakash, S., & Prakash, L. (1990) · Genetics · doi:10.1093/genetics/124.4.817 · Cited by 179 · see citing works
Self-citationTorres‐Ramos, C. A., Prakash, S., & Prakash, L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2419-2426.2002 · Cited by 170 · see citing works
Self-citationLesion Bypass and the Reactivation of Stalled Replication Forks
Marians, K. J. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-011921 · Cited by 163 · see citing works
Radiation-Sensitive Mutants and Repair in Yeast
Game, J. C. (1983) · Springer series in molecular biology · doi:10.1007/978-1-4612-5491-1_4 · Cited by 169 · see citing works
Liu, W., Tang, X., Qi, X., Fu, X., Ghimire, S., Ma, R., Li, S., Zhang, N., & Si, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082894 · Cited by 156 · see citing works
Visualization of recombination-mediated damage bypass by template switching
Giannattasio, M., Zwicky, K., Follonier, C., Foiani, M., Lopes, M., & Branzei, D. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2888 · Cited by 147 · see citing works
DNA damage tolerance by recombination: Molecular pathways and DNA structures
Branzei, D., & Szakál, B. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.008 · Cited by 145 · see citing works
Jones, J. S., Weber, S. C., & Prakash, L. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.14.7119 · Cited by 147 · see citing works
Self-citationReynolds, P. R., Weber, S., & Prakash, L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.168 · Cited by 147 · see citing works
Self-citationRAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells
Yamashita, Y. M., Okada, T., Matsusaka, T., Sonoda, E., Zhao, G. Y., Araki, K., Tateishi, S., Yamaizumi, M., & Takeda, S. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf534 · Cited by 144 · see citing works
Tateishi, S., Sakuraba, Y., Masuyama, S., Inoue, H., & Yamaizumi, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.7927 · Cited by 140 · see citing works
Haracska, L., Unk, I., Prakash, L., & Prakash, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510924103 · Cited by 136 · see citing works
Self-citationInterplay of replication checkpoints and repair proteins at stalled replication forks
Branzei, D., & Foiani, M. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.018 · Cited by 133 · see citing works
Paulovich, A. G., Armour, C. D., & Hartwell, L. H. (1998) · Genetics · doi:10.1093/genetics/150.1.75 · Cited by 133 · see citing works
Schiestl, R. H., Reynolds, P. R., Prakash, S., & Prakash, L. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.5.1882 · Cited by 133 · see citing works
Self-citationVanoli, F., Fumasoni, M., Szakál, B., Maloisel, L., & Branzei, D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001205 · Cited by 127 · see citing works
Barbour, L., & Xiao, W. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.014 · Cited by 125 · see citing works
Tateishi, S., Niwa, H., Miyazaki, J., Fujimoto, S., Inoue, H., & Yamaizumi, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.474-481.2003 · Cited by 120 · see citing works
Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations
Chiu, R. K., Brun, J., Ramaekers, C. H. M. A., Theys, J., Weng, L., Lambin, P., Gray, D. A., & Wouters, B. G. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0020116 · Cited by 123 · see citing works
Miller, R. D., Prakash, L., & Prakash, S. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.8.939 · Cited by 121 · see citing works
Self-citationMinca, E. C., & Kowalski, D. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.020 · Cited by 115 · see citing works
Analysis of the mechanism for reversion of a disrupted gene.
Schiestl, R. H., Igarashi, S., & Hastings, P. J. (1988) · Genetics · doi:10.1093/genetics/119.2.237 · Cited by 115 · see citing works
To skip or not to skip: choosing repriming to tolerate DNA damage
Quinet, A., Tirman, S., Cybulla, E., Meroni, A., & Vindigni, A. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.012 · Cited by 109 · see citing works
YeastRAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins
Bankmann, M., Prakash, L., & Prakash, S. (1992) · Nature · doi:10.1038/355555a0 · Cited by 113 · see citing works
Self-citationReverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.
Yamazoe, M., Sonoda, E., Hochegger, H., & Takeda, S. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.039 · Cited by 116 · see citing works
Replication of damaged DNA in mammalian cells: new solutions to an old problem
Lehmann, A. R. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00227-0 · Cited by 111 · see citing works
Inefficient Bypass of an Abasic Site by DNA Polymerase η
Haracska, L., Washington, M. T., Prakash, S., & Prakash, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008021200 · Cited by 110 · see citing works
Self-citationBailly, V., Prakash, S., & Prakash, L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4536 · Cited by 109 · see citing works
Self-citationFlott, S., Alabert, C., Toh, G. W., Toth, R., Sugawara, N., Campbell, D. G., Haber, J. E., Pasero, P., & Rouse, J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00135-07 · Cited by 107 · see citing works
Johnson, R. E., Prakash, S., & Prakash, L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46922-0 · Cited by 105 · see citing works
Self-citationRequirement of proliferating cell nuclear antigen in RAD6-dependent postreplicational DNA repair.
Torres‐Ramos, C. A., Yoder, B. L., Burgers, P., Prakash, S., & Prakash, L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9676 · Cited by 105 · see citing works
Self-citationThe yeast Shu complex couples error‐free post‐replication repair to homologous recombination
Ball, L. G., Zhang, K., Cobb, J. A., Boone, C. M., & Xiao, W. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06748.x · Cited by 98 · see citing works
Morrison, A., Miller, E. J., & Prakash, L. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.3.1179 · Cited by 104 · see citing works
Self-citationRegulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase.
Peterson, T., Prakash, L., Prakash, S., Osley, M. A., & Reed, S. I. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.1.226 · Cited by 98 · see citing works
Self-citationLiefshitz, B., Steinlauf, R., Friedl, A. A., Eckardt‐Schupp, F., & Kupiec, M. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(97)00070-0 · Cited by 97 · see citing works
Regulation of histone H2A and H2B ubiquitylation
Osley, M. A. (2006) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/ell022 · Cited by 96 · see citing works
Gangavarapu, V., Prakash, S., & Prakash, L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01331-07 · Cited by 92 · see citing works
Self-citationRad51 replication fork recruitment is required for DNA damage tolerance
González‐Prieto, R., Muñoz-Cabello, A. M., Cabello-Lobato, M. J., & Prado, F. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.73 · Cited by 89 · see citing works
Competition, collaboration and coordination – determining how cells bypass DNA damage
Sale, J. E. (2012) · Journal of Cell Science · doi:10.1242/jcs.094748 · Cited by 88 · see citing works
A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability
Budd, M. E., Tong, A. H. Y., Polaczek, P., Peng, X. P., Boone, C. M., & Campbell, J. L. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010061 · Cited by 88 · see citing works
Reynolds, P. R., Koken, M. H. M., Hoeijmakers, J. H. J., Prakash, S., & Prakash, L. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08258.x · Cited by 88 · see citing works
Self-citationPrecise genome-wide base editing by the CRISPR Nickase system in yeast
Satomura, A., Nishioka, R., Mori, H., Sato, K., Kuroda, K., & Ueda, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02013-7 · Cited by 86 · see citing works
Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage
Rouse, J. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600129 · Cited by 85 · see citing works
Hishida, T., Ohno, T., Iwasaki, H., & Shinagawa, H. (2002) · The EMBO Journal · doi:10.1093/emboj/21.8.2019 · Cited by 85 · see citing works
Ubiquitin family modifications and template switching
Branzei, D. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.053 · Cited by 83 · see citing works
The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells
Liu, N., Lamerdin, J. E., Tucker, J. D., Zhou, Z.-Q., Walter, C. A., Albala, J. S., Busch, D. B., & Thompson, L. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9232 · Cited by 83 · see citing works
Baynton, K., Roy, A. K., & Fuchs, R. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.960 · Cited by 81 · see citing works
Sancar, G. B., & Smith, F. W. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.4767-4776.1989 · Cited by 81 · see citing works
Differential Regulation of Rad18 through Rad6-dependent Mono- and Polyubiquitination
Miyase, S., Tateishi, S., Watanabe, K., Tomita, K., Suzuki, K., Inoue, H., & Yamaizumi, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409219200 · Cited by 79 · see citing works
Xiao, W., Chow, B. L., Fontanie, T., Ma, L., Bacchetti, S., Hryciw, T., & Broomfield, S. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00034-8 · Cited by 80 · see citing works
Montelone, B. A., Prakash, S., & Prakash, L. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00352514 · Cited by 80 · see citing works
Self-citationRAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light
Hishida, T., Kubota, Y., Carr, A. M., & Iwasaki, H. (2009) · Nature · doi:10.1038/nature07580 · Cited by 77 · see citing works
Curtis, M. J., & Hays, J. B. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.03.004 · Cited by 77 · see citing works
Xu, X., Lin, A., Zhou, C., Blackwell, S., Zhang, Y., Wang, Z., Feng, Q., Guan, R., Hanna, M. D., Chen, Z., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw183 · Cited by 76 · see citing works
Game, J. C., & Kaufman, P. D. (1999) · Genetics · doi:10.1093/genetics/151.2.485 · Cited by 76 · see citing works
Wong, R. P. C., García‐Rodríguez, N., Zilio, N., Hanulová, M., & Ulrich, H. D. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.015 · Cited by 72 · see citing works
Timing and spacing of ubiquitin‐dependent DNA damage bypass
Ulrich, H. D. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.028 · Cited by 73 · see citing works
Worthylake, D. K., Prakash, S., Prakash, L., & Hill, C. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6271 · Cited by 74 · see citing works
Self-citationDhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6.
Koken, M. H. M., Reynolds, P., Bootsma, D., Hoeijmakers, J. H. J., Prakash, S., & Prakash, L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3832 · Cited by 74 · see citing works
Self-citationBudd, M. E., & Campbell, J. L. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00072-5 · Cited by 72 · see citing works
OTOMO, T., Hishii, M., Arai, H., Sato, K., & SASAI, K. (2004) · Journal of Radiation Research · doi:10.1269/jrr.45.53 · Cited by 71 · see citing works
DNA damage-induced mutation: tolerance via translesion synthesis
Kunz, B. A., Straffon, A. F. L., & Vonarx, E. J. (2000) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00048-8 · Cited by 71 · see citing works
Friedl, A. A., Liefshitz, B., Steinlauf, R., & Kupiec, M. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00086-6 · Cited by 70 · see citing works
Giannattasio, M., & Branzei, D. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2474-4 · Cited by 67 · see citing works
Ulrich, H. D. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.17.3487 · Cited by 69 · see citing works
Broomfield, S. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.3.732 · Cited by 67 · see citing works
- Authors
- Prakash, L.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Prakash, Louise
- ORCID
- Prakash, Louise
- Venue
- Molecular and General Genetics MGG
- Published
- 1981-12
- Volume
- 184
- Issue
- 3
- Pages
- 471-478
- ISSN
- 0026-8925 (ISSN-L)
- 1432-1874
- OpenAlex
- W2045887257
- Cited by
- 291
- References
- 57
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2022: 2 · 2021: 8 · 2020: 10 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 3
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular and General Genetics MGG (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- postreplication repair, Saccharomyces cerevisiae, UV-induced DNA damage, thymine dimers, DNA replication block, Rad6, RAD18, REV3, RAD52, mitochondrial DNA deletions, cycloheximide, recombinational repair, error-free repair
- MeSH terms
- Cycloheximide, DNA Repair, DNA Replication, DNA, Fungal, Kinetics, Molecular Weight, Mutation, Saccharomyces cerevisiae, Spheroplasts, Ultraviolet Rays
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
