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Moving up the hierarchy: A hypothesis on the evolution of a genetic sex determination pathway
Abstract
A hypothesis on the evolutionary origin of the genetic pathway of sex determination in the nematode Caenorhabditis elegans is presented here. It is suggested that the pathway arose in steps, driven by frequency‐dependent selection for the minority sex at each step, and involving the sequential acquisition of dominant negative, neomorphic genetic switches, each one reversing the action of the previous one. A central implication is that the genetic pathway evolved in reverse order from the final step in the hierarchy up to the first. The possible applicability of the model to the other well‐characterized sex determination pathway, that of Drosophila melanogaster, and to sex determination in mammals, is discussed, along with some potential implications for pathway evolution in general. Finally, the specific molecular and population genetic questions that the model raises are described and some tests are proposed.
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Cites
The genetical theory of natural selection
Fisher, R. A. (1930) · doi:10.5962/bhl.title.27468 · Cited by 17,617
Cited by
Evidence for evolutionary conservation of sex-determining genes
Raymond, C. S., Shamu, C. E., Shen, M. M., Seifert, K. J., Hirsch, B., Hodgkin, J., & Zarkower, D. (1998) · Nature · doi:10.1038/35618 · Cited by 802
Pax 6: mastering eye morphogenesis and eye evolution
Gehring, W. J., & Ikeo, K. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01776-x · Cited by 758
The evolution of signalling pathways in animal development
Pires-daSilva, A., & Sommer, R. J. (2003) · Nature Reviews Genetics · doi:10.1038/nrg977 · Cited by 466
The Master Sex-Determination Locus in Threespine Sticklebacks Is on a Nascent Y Chromosome
Peichel, C. L., Ross, J. A., Matson, C. K., Dickson, M., Grimwood, J., Schmutz, J., Myers, R. M., Mori, S., Schluter, D., & Kingsley, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.030 · Cited by 420
Metadata
- Authors
- Wilkins, A. S.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1995-01
- Volume
- 17
- Issue
- 1
- Pages
- 71-77
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2084518266
- Cited by
- 339
- References
- 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wilkins, A. S. (1995). Moving up the hierarchy: A hypothesis on the evolution of a genetic sex determination pathway. BioEssays. https://doi.org/10.1002/bies.950170113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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