Fish are like flies are like frogs: conservation of dorsal-ventral patterning mechanisms
Abstract
Genetic analysis of Drosophila has shown that a morphogenetic gradient of the Transforming Growth Factor‐β family member dpp patterns the embryonic dorsalventral axis. Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp‐4 , the dpp homolog, in patterning the dorsalventral axis of chordates. A recent report has now identified mutations in two genes, dino and swirl , that disrupt dorsal‐ventral patterning in the zebrafish Danio rerio (1) . Characterization of these mutations parallels findings from Drosophila , thus establishing a genetic framework for the analysis of dorsalventral patterning in a vertebrate.
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Human and murine Noggin exhibit high sequence homology and functional equivalence.
“Human and murine Noggin exhibit high sequence homology and functional equivalence (Holley and Ferguson, 1997; Pauklin and Vallier, 2015), with comparable pricing (recombinant human Noggin, €9.54/µg; recombinant murine Noggin, €10.93/µg, R&D Systems, Bio-Techne GmbH, Germany, pricing for 6 March 2026).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Holley and Ferguson, 1997
Cites
Francois, V, Solloway, M., O'Neill, J. W., Emery, J., & Bier, E. (1994) · Genes & Development · doi:10.1101/gad.8.21.2602 · Cited by 308 · see citing works
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Localized expression of a <i>dpp</i> / <i>BMP2</i> / <i>4</i> ortholog in a coral embryo
Hayward, D. C., Samuel, G., Pontynen, P. C., Catmull, J., Saint, R., Miller, D. J., & Ball, E. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112021499 · Cited by 132 · see citing works
A simple plan-Cnidarians and the origins of developmental mechanisms
Ball, E. E., Hayward, D. C., Saint, R., & Miller, D. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1402 · Cited by 123 · see citing works
The mouth, the anus, and the blastopore—open questions about questionable openings
Hejnol, A., & Martindale, M. Q. (2009) · Animal Evolution · doi:10.1093/acprof:oso/9780199549429.003.0004 · Cited by 37 · see citing works
Genomic, phylogenetic, and cell biological insights into metazoan origins
Nichols, S. A., Dayel, M. J., & King, N. (2009) · Animal Evolution · doi:10.1093/acprof:oso/9780199549429.003.0003 · Cited by 24 · see citing works
Spänle, J. V., Haiber, L. M., & Seeger, B. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1800157 · Cited by 1 · see citing works
- Authors
- Holley, S. A., & Ferguson, E. L.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1997-04
- Volume
- 19
- Issue
- 4
- Pages
- 281-284
- ISSN
- 0265-9247
- 1521-1878
- Cited by
- 89
- References
- 1
- Language
- en
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