Localized expression of a dpp / BMP2 / 4 ortholog in a coral embryo
Open accessAbstract
As the closest outgroup to the Bilateria, the Phylum Cnidaria is likely to be critical to understanding the origins and evolution of body axes. Proteins of the decapentaplegic (DPP)/bone morphogenetic protein (BMP) 2/4 subfamily are central to the specification of the dorsoventral (D/V) axis in bilateral animals, albeit with an axis inversion between arthropods and chordates. We show that a dpp/BMP2/4 ortholog (bmp2/4-Am) is present in the reef-building scleractinian coral, Acropora millepora (Class Anthozoa) and that it is capable of causing phenotypic effects in Drosophila that mimic those of the endogenous dpp gene. We also show that, during coral embryonic development, bmp2/4-Am expression is localized in an ectodermal region adjacent to the blastopore. Thus, a representative of the DPP/BMP2/4 subfamily of ligands was present in the common ancestor of diploblastic and triploblastic animals where it was probably expressed in a localized fashion during development. A localized source of DPP/BMP2/4 may have already been used in axis formation in this ancestor, or it may have provided a means by which an axis could evolve in triploblastic animals.
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A growing body of cnidarian molecular data suggests that these animals use essentially the same genes for axis formation, development, and body function maintenance as bilaterians.
“A growing set of molecular data from cnidarians suggests that these”
From Evolutionary aspects of developmentally regulated helix-loop-helix transcription factors in striated muscle of jellyfish (2003) · cites this paper as Hayward et al., 2002
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- Authors
- Hayward, D. C., Samuel, G., Pontynen, P. C., Catmull, J., Saint, R., Miller, D. J., & Ball, E. E.
- Affiliations
- Australian National University (AU)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-06-04
- Volume
- 99
- Issue
- 12
- Pages
- 8106-8111
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC123028
- OpenAlex
- W2111333753
- Cited by
- 132
- References
- 34
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 3 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Physical Sciences › Environmental Science › Ecology › Coral and Marine Ecosystems Studies
- Keywords
- decapentaplegic, BMP2/4, Acropora millepora, scleractinian corals, dorsal-ventral axis, Cnidaria, blastopore, ectoderm
- MeSH terms
- Amino Acid Sequence, Animals, Cnidaria, Embryo, Nonmammalian, Molecular Sequence Data, Phylogeny, Transforming Growth Factor beta, Sequence Alignment, Sequence Homology, Amino Acid, Gene Expression Regulation, Developmental, Bone Morphogenetic Proteins, Drosophila Proteins, Bone Morphogenetic Protein 2, Bone Morphogenetic Protein 4
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