The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Imaging of light emission from the expression of luciferases in living cells and organisms: a review
Open accessAbstract
Luciferases are enzymes that emit light in the presence of oxygen and a substrate (luciferin) and which have been used for real‐time, low‐light imaging of gene expression in cell cultures, individual cells, whole organisms, and transgenic organisms. Such luciferin–luciferase systems include, among others, the bacterial lux genes of terrestrial Photorhabdus luminescens and marine Vibrio harveyi bacteria, as well as eukaryotic luciferase luc and ruc genes from firefly species (Photinus) and the sea panzy (Renilla reniformis), respectively. In various vectors and in fusion constructs with other gene products such as green fluorescence protein (GFP; from the jellyfish Aequorea), luciferases have served as reporters in a number of promoter search and targeted gene expression experiments over the last two decades. Luciferase imaging has also been used to trace bacterial and viral infection in vivo and to visualize the proliferation of tumour cells in animal models. Copyright © 2002 John Wiley & Sons, Ltd.
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Cites
Firefly luciferase gene: structure and expression in mammalian cells.
de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,087
Shimomura, O., Johnson, F. H., & Saiga, Y. (1962) · Journal of Cellular and Comparative Physiology · doi:10.1002/jcp.1030590302 · Cited by 2,384
Primary structure of the Aequorea victoria green-fluorescent protein
Prasher, D. C., Eckenrode, V. K., Ward, W. W., Prendergast, F. G., & Cormier, M. J. (1992) · Gene · doi:10.1016/0378-1119(92)90691-h · Cited by 2,177
Koncz, C., & Schell, J. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf00331014 · Cited by 2,032
Regulation of mitochondrial ATP synthesis by calcium: Evidence for a long-term metabolic priming
Jouaville, L. S., Pinton, P., Bastianutto, C., Rutter, G. A., & Rizzuto, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13807 · Cited by 815
Transient and Stable Expression of the Firefly Luciferase Gene in Plant Cells and Transgenic Plants
Ow, D. W., Wood, K. V., DeLuca, M., de Wet, J. R., Helinski, D. R., & Howell, S. H. (1986) · Science · doi:10.1126/science.234.4778.856 · Cited by 725
Photonic detection of bacterial pathogens in living hosts
Contag, C. H., Contag, P. R., Mullins, J. I., Spilman, S. D., Stevenson, D. K., & Benaron, D. A. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_18040593.x · Cited by 652
Circadian Clock Mutants in Arabidopsis Identified by Luciferase Imaging
Millar, A. J., Carré, I. A., Strayer, C. A., Chua, N.-H., & Kay, S. A. (1995) · Science · doi:10.1126/science.7855595 · Cited by 604
Wilson, T., & Hastings, J. W. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.197 · Cited by 570
Ishitani, M., Xiong, L., Stevenson, B., & Zhu, J. K. (1997) · The Plant Cell · doi:10.1105/tpc.9.11.1935 · Cited by 531
Cited by
Welsh, D. K., Yoo, S.-H., Liu, A. C., Takahashi, J. S., & Kay, S. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.057 · Cited by 726
Applications of bioluminescence in biotechnology and beyond
Syed, A. J., & Anderson, J. C. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01492c · Cited by 341
In vivo molecular and genomic imaging: new challenges for imaging physics
Cherry, S. R. (2004) · Physics in Medicine and Biology · doi:10.1088/0031-9155/49/3/r01 · Cited by 334
Bioluminescence imaging in living organisms
Welsh, D. K., & Kay, S. A. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2004.12.006 · Cited by 185
Influence of mesenchymal stem cells on metastasis development in mice in vivo
Meleshina, A. V., Cherkasova, E. I., Shirmanova, M. V., Klementieva, N. V., Kiseleva, E. V., Snopova, L. В., Prodanets, N. N., & Zagaynova, E. V. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0003-7 · Cited by 45
Metadata
- Authors
- Greer, L. F., & Szalay, A. A.
- Venue
- Luminescence
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 17
- Issue
- 1
- Pages
- 43-74
- ISSN
- 1522-7235 (ISSN-L)
- 1522-7243
- OpenAlex
- W2040744436
- Cited by
- 379
- References
- 110
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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